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Alzheimer's Disease
Henry W. Querfurth, Frank M. LaFerla. New England Journal of Medicine, 2010-01-27
Topic: Amyloid, tau and blood-test diagnosis
This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.
Why it matters
This review brings together findings on how Alzheimer's disease develops and ties them to the build-up of misfolded proteins. These proteins cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction, the basis of the loss of thinking ability.
How this study scored 59/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 56 of the 95 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (New England Journal of Medicine) |
| Journal's citation record | 4 / 4 | New England Journal of Medicine: journal h-index 1,505 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 4,470 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 248.3 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 6 / 6 | Cited 139.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 568 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Frank M. LaFerla: h-index 114 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20107219) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 56 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 95 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Querfurth, H. W., & LaFerla, F. M. (2010). Alzheimer's Disease. New England Journal of Medicine. https://doi.org/10.1056/nejmra0909142
Vancouver
Querfurth HW, LaFerla FM. Alzheimer's Disease. New England Journal of Medicine. 2010. doi:10.1056/nejmra0909142. PMID: 20107219.
BibTeX
@article{querfurth2010-20107219,
author = {Querfurth, Henry W. and LaFerla, Frank M.},
title = {{Alzheimer's Disease}},
journal = {New England Journal of Medicine},
year = {2010},
doi = {10.1056/nejmra0909142},
pmid = {20107219},
url = {https://doi.org/10.1056/nejmra0909142}
}
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