Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,251–22,275 of 27,380 studies, newest first · page 891 of 1096.
January 2008 25
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2008-01-10
Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
59/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: (18)F-BAY94-9172 binding matched the reported post-mortem distribution of Abeta plaques. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-09
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The cysteine protease inhibitors CA074Me and E64d were selected by inhibition of beta-secretase activity in regulated secretory vesicles that produce beta-amyloid (Abeta). +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-08
Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients
48/100 ✓ Peer-reviewed Caregiving Acta neuropathologica
Key finding: We have found that the overall Abeta plaque burden and, in particular, the diffuse plaque load shows a statistically significant 'large' correlation with the overall cortical LB burden.
Full summary, score breakdown and related studies → Original source
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2008-01-05
Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition
43/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease
Key finding: Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-05
Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
46/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of disease
Key finding: Accumulated evidence indicates that lipid peroxidation is an early event during the evolution of the disease and occurs in patients with mild cognitive impairment (MCI). +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-03
Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension
47/100 ✓ Peer-reviewed Brain scans and imaging Stroke
Key finding: Cognitively normal subjects with HTN (n=19) had decreased rCBF in the putamen, globus pallidus, bilaterally, and in the left hippocampus compared with normotensives (n=22).
Full summary, score breakdown and related studies → Original source
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2008-01-02
Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study
78/100 ✓ Peer-reviewed Caregiving BMJ (Clinical research ed.)
Key finding: Community occupational therapy intervention for patients with dementia and their care givers is successful and cost effective, especially in terms of informal care giving. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Understanding nutrition, depression and mental illnesses
50/100 ✓ Peer-reviewed Brain scans and imaging Indian Journal of Psychiatry
Key finding: The most common mental disorders that are currently prevalent in numerous countries are depression, bipolar disorder, schizophrenia, and obsessive-compulsive disorder (OCD).[2] The dietary intake pattern of the general population in many Asian and American countries reflects that they are often deficient in many nutrients, especially essential vitamins, minerals, and omega-3 fatty acids.[3] A notable feature of the diets of patients suffering from mental disorders is the severity of deficiency in these nutrients.[3] Studies have indicated that daily supplements of vital nutrients are often effective in reducing patients' symptoms.[4] Supplements containing amino acids have also been found to reduce symptoms, as they are converted to neurotransmitters which in turn alleviate depression and other mental health problems.[4] On the basis of accumulating scientific evidence, an effective therapeutic intervention is emerging, namely nutritional supplement/treatment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008 year only
Using principles of diffusion of innovation to improve nursing home care
38/100 ✓ Peer-reviewed Health systems and care delivery Journal of nursing care quality
Key finding: Use of these principles was associated with increased assessment in response to behavior change, increased administration of analgesics, and a significant decrease in resident behavioral symptoms. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008 year only
Family caregiver burden by relationship to care recipient with dementia in Korea
45/100 ✓ Peer-reviewed Caregiving Geriatric nursing (New York, N.Y.)
Key finding: Those cared for by daughters-in-law were older and demonstrated more memory and behavioral problems than those by spouses, sons, or daughters.
Full summary, score breakdown and related studies → Original source
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2008 year only
A new Brief computerized cognitive screening battery (CompCogs) for early diagnosis of Alzheimer's disease
41/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia & neuropsychologia
Key finding: CompCogs included the Face test (correct response) and Word and Forms with Short term memory tests (reaction time). +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Guidelines for management of idiopathic normal pressure hydrocephalus
36/100 ✓ Peer-reviewed Digital health tools Neurologia medico-chirurgica
Key finding: They propose three diagnostic levels; possible, probable, and definite. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Targeting mitochondria
36/100 ✓ Peer-reviewed Disease mechanisms Accounts of chemical research
Key finding: ROS and RNS escape results in the activation of cytosolic stress pathways, DNA damage, and the upregulation of JNK, p38, and p53.
Full summary, score breakdown and related studies → Original source
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2008-01-01
The blood-brain barrier in health and chronic neurodegenerative disorders
36/100 ✓ Peer-reviewed Inflammation and the immune system Neuron
Key finding: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the BBB and other nonneuronal cells of the neurovascular unit.
Full summary, score breakdown and related studies → Original source
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2008-01-01
Treatment of Susac's Syndrome
36/100 ✓ Peer-reviewed Risk factors Current treatment options in neurology
Key finding: The encephalopathy is usually associated with headaches, multifocal neurologic manifestations, and psychiatric features (particularly paranoia). +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments Current medicinal chemistry
Key finding: The therapeutic arsenal for the treatment of Alzheimer's disease (AD) remains confined to a group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to provide a relief of the very late symptoms of the dementia, i.e. the cognitive and functional decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis
64/100 ✓ Peer-reviewed Treatments Clinical interventions in aging
Key finding: Meta-analyses of placebo-controlled data support the drugs' modest overall benefits for stabilizing or slowing decline in cognition, function, behavior, and clinical global change. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
36/100 ✓ Peer-reviewed Vascular contributions Journal of molecular neuroscience : MN
Key finding: Diffusion tensor imaging is constantly validated, challenged, and developed in terms of acquisition scheme, image processing, analysis, and interpretation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Structural and functional plasticity of the human brain in posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Progress in brain research
Key finding: Posttraumatic stress disorder (PTSD) is associated with long-term changes in neurobiology.
Full summary, score breakdown and related studies → Original source
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2008-01-01
Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus
Key finding: Data from adults suggest that hippocampal volume deficits are associated with PTSD, whereas findings from children with PTSD generally show no hippocampal volume deficits in PTSD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2008-01-01
Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuropsychiatry and clinical neurosciences
Key finding: Volumetric MRI scans from 26 women with repeated episodes of childhood sexual abuse and 17 healthy female comparison subjects (ages 18-22 years) were analyzed for sensitive period effects on hippocampal and amygdala volume, frontal cortex gray matter volume and corpus callosum area. +3 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Lifestyle-related factors in predementia and dementia syndromes
55/100 ✓ Peer-reviewed Prevention trials Expert review of neurotherapeutics
Key finding: Since the therapeutic options currently available have demonstrated limited efficacy, the search for preventive strategies for cognitive decline and dementia are mandatory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
S100 protein family and its application in clinical practice
36/100 ✓ Peer-reviewed Disease mechanisms Hippokratia
Key finding: They exert their actions usually through calcium binding, although Zn2+ and Cu2+ have also been shown to regulate their biological activity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2008-01-01
Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Current pharmaceutical design
Key finding: These observations suggest that Glycer-AGE play a role in the pathogenesis of AD.
Full summary, score breakdown and related studies → Original source
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2008-01-01
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: This indicates that these changes are related to Tau expression rather than aggregation.
Full summary, score breakdown and related studies → Original source
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