Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,376–20,400 of 27,380 studies, newest first · page 816 of 1096.
January 2011 19
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2011-01-01
Effects of hypoperfusion in Alzheimer's disease
45/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Disrupted perfusion is not only evident throughout disease manifestation, it is also demonstrated during the pre-clinical phase of AD (i.e., mild cognitive impairment) as well as in cognitively healthy persons at high-risk for developing AD due to family history or genetic factors. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease
48/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Synaptic loss is one of the hallmarks of AD and associated with cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology
Key finding: Triplication of chromosome 21 in Down syndrome (DS) results in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
69/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Notably, DID (per 10,000 person-years)was markedly increased with DM (without medication), compared to DM free subjects (119 versus 46). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Muscles and their myokines
47/100 ✓ Peer-reviewed Risk factors The Journal of experimental biology
Key finding: We have suggested that cytokines or other peptides that are produced, expressed and released by muscle fibres and exert autocrine, paracrine or endocrine effects should be classified as 'myokines'. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States
57/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Although some decline was observed in the Minnesota cohort, no statistically significant trends were apparent in the community studies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases
43/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD
Key finding: Human epidemiological and new animal data suggest that green and black tea drinking (enriched in a class of flavonoids named catechins) may help protecting the aging brain and reduce the incidence of dementia, AD, and PD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline
60/100 ✓ Peer-reviewed Disparities JAMA
Key finding: Lower plasma β-amyloid 42 and 42/40 levels have been associated with incident dementia, but results are conflicting and few have investigated cognitive decline among elders without dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
A systematic review of ethnicity and pathways to care in dementia
57/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry
Key finding: There are significant barriers to help seeking for dementia in ME groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Of sound mind and body: depression, disease, and accelerated aging
44/100 ✓ Peer-reviewed Caregiving Dialogues in clinical neuroscience
Key finding: Major depressive disorder (MDD) is associated with a high rate of developing serious medical comorbidities such as cardiovascular disease, stroke, dementia, osteoporosis, diabetes, and the metabolic syndrome. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months
61/100 ✓ Peer-reviewed Brain scans and imaging International journal of geriatric psychiatry
Key finding: A framework for multi-centre MRI studies of Alzheimer's disease has been established consisting of a harmonized MRI acquisition protocol across centres, rigorous QC at both the sites and central data analysis hub and an automated image analysis pipeline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma
49/100 ✓ Peer-reviewed Getting a diagnosis Clinics in sports medicine
Key finding: Chronic traumatic encephalopathy (CTE) is a form of neurodegeneration believed to result from repeated head injuries. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Use of florbetapir-PET for imaging beta-amyloid pathology
67/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Florbetapir-PET imaging was performed a mean of 99 days (range, 1-377 days) before death for the 29 individuals in the primary analysis cohort. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea
54/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD
Key finding: Age-, gender-, education-, and urbanicity-standardized prevalence of dementia was estimated to be 8.1% (95% CI = 6.9-9.2) for overall dementia and 24.1% (95% CI = 21.0-27.2) for MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial
16/100 ⚠ Retracted — do not rely on it Treatments The Kurume medical journal
Key finding: The relative risk in the treatment group compared with the control group was 0.31 (95% confidence interval, 0.12-0.81). +1 more finding
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2011-01-01
Effectiveness of a modified Continuum curriculum for medical students: a randomized trial
66/100 ✓ Peer-reviewed Treatments Neurology
Key finding: The Continuum: Dementia for Medical Students curriculum provided an inexpensive and readily implementable means for improving medical knowledge of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Donepezil significantly improves abilities in daily lives of female Down syndrome patients with severe cognitive impairment: a 24-week randomized, double-blind, placebo-controlled trial
57/100 ✓ Peer-reviewed Treatments International journal of psychiatry in medicine
Key finding: Donepezil may effectively and safely improve overall functioning of DS patients with severe cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-01-01
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
63/100 ✓ Peer-reviewed Genetics Annals of neurology
Key finding: Aβ deposition increases slowly from cognitive normality to moderate severity DAT. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-01-01
Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1
46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. +3 more findings
Full summary, score breakdown and related studies → Original source
December 2010 6
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2010-12-30
Over- and under-diagnosis of dementia in ethnic minorities: a nationwide register-based study
46/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry
Key finding: Dementia is under-diagnosed to a greater extent among ethnic minorities in the age group 60 years and older but is over-diagnosed in the age group younger than 60 years. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-12-29
Hypertension is a potential risk factor for vascular dementia: systematic review
78/100 ✓ Peer-reviewed Vascular contributions International journal of geriatric psychiatry
Key finding: Hypertension significantly increases the risk of vascular dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-12-29
Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study
51/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Niemann-Pick disease type C (NPC) is an inherited disorder characterized by intracellular accumulation of lipids such as cholesterol and glycosphingolipids in endosomes and lysosomes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-12-28
PET imaging of brain amyloid in dementia: a review
36/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: PIB-PET imaging is a sensitive and specific marker for underlying Aβ amyloid deposition and represents an important investigative tool for examining the relationship between amyloid burden, clinical symptoms and structural and functional changes in dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-12-27
Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders
36/100 ✓ Peer-reviewed Disease mechanisms CNS neuroscience & therapeutics
Key finding: Bioavailabilty versus intraperitoneal dosing is about 12%. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-12-24
APOE ε 4 allele and CSF APOE on cognition in HIV-infected subjects
38/100 ✓ Peer-reviewed Genetics Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Key finding: However, APOE ε 4 allele has been associated with greater incidence of HIV-associated dementia and accelerated progression of HIV infection. +1 more finding
Full summary, score breakdown and related studies → Original source
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