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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,751–19,775 of 27,380 studies, newest first · page 791 of 1096.

January 2012 2

  1. 2012-01-01

    Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

    ✓ Peer-reviewed Biomarkers Prion

    Key finding: In these animals, immunohistochemistry analyses showed that deposition of PrP (Sc) in the cerebellum, hippocampus and parietal cortex in CHF5074-treated mice was significantly lower than in vehicle-treated animals. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2012-01-01

    Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue

    ✓ Peer-reviewed Biomarkers Alzheimer disease and associated disorders

    Key finding: Florbetapir F 18 selectively binds Aβ in human brain tissue. +3 more findings

    Full summary, score breakdown and related studies → Original source

December 2011 23

  1. 2011-12-30

    Risk of Mortality Among Individual Antipsychotics in Patients With Dementia

    ✓ Peer-reviewed Clinical safety American Journal of Psychiatry

    Key finding: In covariate-adjusted intent-to-treat analyses, haloperidol was associated with the highest mortality rates (relative risk=1.54, 95% confidence interval [CI]=1.38-1.73) followed by risperidone (reference), olanzapine (relative risk=0.99, 95% CI=0.89-1.10), valproic acid and its derivatives (relative risk=0.91, 95% CI=0.78-1.06), and quetiapine (relative risk=0.73, 95% CI=0.67-0.80). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2011-12-29

    Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy

    ✓ Peer-reviewed Hippocampus size on brain scans Breast cancer research and treatment

    Key finding: A limited number of studies have associated adjuvant chemotherapy with structural brain changes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2011-12-29

    Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients

    ✓ Peer-reviewed Clinical safety Critical care (London, England)

    Key finding: In inflamed patients, the proinflammatory cytokine IL-8 was associated with delirium, whereas in noninflamed patients, antiinflammatory cytokine IL-10 and Aβ1-42/40 were associated with delirium. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2011-12-27

    Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

    ✓ Peer-reviewed Biomarkers Journal of lipid research

    Key finding: The analysis revealed that desmosterol was found to be decreased in AD plasma versus controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2011-12-25

    Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

    ✓ Peer-reviewed Risk factors Nature genetics

    Key finding: In vitro, CSF-1 stimulation resulted in rapid autophosphorylation of selected tyrosine residues in the kinase domain of wild-type but not mutant CSF1R, suggesting that HDLS may result from partial loss of CSF1R function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2011-12-21

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    ✓ Peer-reviewed Drug development Reviews in the neurosciences

    Key finding: Considerable evidence suggests that GSK3 is involved in the common pathology underlying Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM).

    Full summary, score breakdown and related studies → Original source

  7. 2011-12-21

    Antioxidants in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Biochimica et biophysica acta

    Key finding: Genes that are overexpressed on chromosome 21 are associated with oxidative stress and neuronal apoptosis.

    Full summary, score breakdown and related studies → Original source

  8. 2011-12-21

    MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: This approach to the detection of individuals at high risk for preclinical AD-identified in single CN individuals using this quantitative ADsig MRI biomarker-may provide investigators with a population enriched for AD pathobiology and with a relatively high likelihood of imminent cognitive decline consistent with prodromal AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2011-12-20

    Autopsy-proven progressive supranuclear palsy presenting as behavioral variant frontotemporal dementia

    ✓ Peer-reviewed Digital health tools Neurocase

    Key finding: In these, at least one cardinal symptom or sign of PSP later emerges, associated with smaller midbrain volume and increased pons/midbrain ratio. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2011-12-19

    Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers ASN neuro

    Key finding: We found significant reduction in both the surface and volume of GFAP-labelled profiles in 3xTg-AD animals from very early ages (1 month) when compared with non-Tg (non-transgenic) controls (48 and 54%, reduction respectively), which was sustained for up to 12 months (33 and 45% reduction respectively). +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2011-12-18

    The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide

    ✓ Peer-reviewed Genetics Nature structural & molecular biology

    Key finding: These results not only elucidate the protective role of clusterin but also provide a molecular basis for the genetic link between clusterin and Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  12. 2011-12-17

    Prestroke dementia is associated with poor outcomes after reperfusion therapy among elderly stroke patients

    ✓ Peer-reviewed End-of-life care Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    Key finding: Among the elderly, prestroke dementia is a powerful independent predictor of in-hospital mortality after acute reperfusion therapy for stroke. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2011-12-16

    Dying in U.S. nursing homes with advanced dementia: how does health care use differ for residents with, versus without, end-of-life Medicare skilled nursing facility care?

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Dual hospice/SNF access may result in fewer hospital deaths and higher quality of life for dying NH residents. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2011-12-15

    New acetylcholinesterase inhibitors for Alzheimer's disease

    ✓ Peer-reviewed Treatments International journal of Alzheimer's disease

    Key finding: Subsequently tacrine, donepezil, rivastigmine, and galantamine were developed and approved for the symptomatic treatment of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2011-12-14

    Long non-coding RNAs in Huntington's disease neurodegeneration

    ✓ Peer-reviewed Brain scans and imaging Neurobiology of disease

    Key finding: Three other lncRNAs of unknown function are also significantly changed in HD brains. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2011-12-14

    Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: Baseline CSF was collected from 512 patients with Alzheimer disease (AD) and 272 patients with other types of dementia (OD), 135 patients with a psychiatric disorder (PSY), and 275 patients with subjective memory complaints (SMC). +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2011-12-14

    Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans

    ✓ Peer-reviewed Risk genes beyond APOE PloS one

    Key finding: While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2011-12-13

    Metabolome in progression to Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Translational psychiatry

    Key finding: MCI confers an increased risk of developing AD, although the state is heterogeneous with several possible outcomes, including even improvement back to normal cognition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2011-12-13

    The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects

    ✓ Peer-reviewed Genetics Cerebral cortex (New York, N.Y. : 1991)

    Key finding: In addition to Apoliprotein E (APOE) ε4, the major genetic risk factor, recent genome-wide association studies (GWAS) have identified a growing list of sequence variations associated with the disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2011-12-09

    Age-associated chronic diseases require age-old medicine: role of chronic inflammation

    ✓ Peer-reviewed Prevention trials Preventive medicine

    Key finding: Although modern science has developed several drugs for treating chronic diseases, most of these drugs are enormously expensive and are associated with serious side effects and morbidity.

    Full summary, score breakdown and related studies → Original source

  21. 2011-12-08

    Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

    ✓ Peer-reviewed Biomarkers The Journal of biological chemistry

    Key finding: We have explored the biophysical and structural properties of physiologically relevant Aβ(42):Aβ(40) ratios by several techniques. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2011-12-08

    A systematic review of the effectiveness of advance care planning interventions for people with cognitive impairment and dementia

    ✓ Peer-reviewed End-of-life care Age and ageing

    Key finding: Our aim was to review systematically the effectiveness of ACP interventions in people with cognitive impairment and dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2011-12-08

    A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

    ✓ Peer-reviewed Disease mechanisms Human molecular genetics

    Key finding: Our results reveal a critical role for PAR-1/MARK kinases in AD pathogenesis and suggest PAR-1/MARK inhibitors as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →