alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 21,101–21,125 of 27,380 studies, newest first · page 845 of 1096.

January 2010 14

  1. 2010-01-01

    In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: [(11)C]-Pittsburgh Compound B (PIB) PET is specific for fibrillar Abeta molecular pathology but not for pathologic diagnosis of comorbid Alzheimer disease in individuals with Parkinson disease dementia.

    Full summary, score breakdown and related studies → Original source

  2. 2010-01-01

    Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: The strong correlation between hippocampal atrophy and beta-amyloid (Abeta) burden in the Pittsburgh compound B-positive healthy control group suggests that Abeta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2010-01-01

    ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia

    ✓ Peer-reviewed Brain scans and imaging Alzheimer disease and associated disorders

    Key finding: Cox regression analyses suggest that baseline hippocampal volume [relative risk (RR)=0.99, P=0.004], baseline right inferior parietal (RR=0.64, P=0.01) and right middle frontal (RR=0.73, P=0.01) perfusion were associated with conversion to dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2010-01-01

    Early-versus late-onset Alzheimer's disease: more than age alone

    ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD

    Key finding: In this retrospective descriptive study, we determined the prevalence of non-memory presentations in a large sample of early-onset AD patients compared to late-onset AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2010-01-01

    Mediterranean diet and cognitive function in older adults

    ✓ Peer-reviewed Prevention and risk Current opinion in clinical nutrition and metabolic care

    Key finding: A high adherence to the Mediterranean diet has been associated with slower cognitive decline, with reduced risk of mild cognitive impairment conversion to Alzheimer's disease and with reduced risk of Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2010-01-01

    Caffeine as a protective factor in dementia and Alzheimer's disease

    ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD

    Key finding: Here, we discuss findings from the longitudinal epidemiological studies about caffeine/coffee/tea and dementia/AD/cognitive functioning with a special emphasis on our recent results from the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2010-01-01

    Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease

    ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD

    Key finding: Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2010-01-01

    Physical exercise, aging, and mild cognitive impairment: a population-based study

    ✓ Peer-reviewed Prevention and risk Archives of neurology

    Key finding: In this population-based case-control study, any frequency of moderate exercise performed in midlife or late life was associated with a reduced odds of having MCI. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2010-01-01

    Outcome over seven years of healthy adults with and without subjective cognitive impairment

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Follow-up occurred during a mean period of 6.8 +/- 3.4 years, and subjects had a mean of 2.9 +/- 1.6 follow-up visits. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2010-01-01

    Effects of aerobic exercise on mild cognitive impairment: a controlled trial

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: Six months of high-intensity aerobic exercise had sex-specific effects on cognition, glucose metabolism, and hypothalamic-pituitary-adrenal axis and trophic activity despite comparable gains in cardiorespiratory fitness and body fat reduction. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2010-01-01

    Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia

    ✓ Peer-reviewed Genetics JAMA

    Key finding: This preliminary report suggests that CETP V405 valine homozygosity is associated with slower memory decline and lower incident dementia and AD risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2010-01-01

    APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging

    ✓ Peer-reviewed Genetics Archives of neurology

    Key finding: Our findings suggest that APOE epsilon4-mediated risk for Alzheimer disease is associated with widespread decline in rCBF over time that precedes the onset of dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2010-01-01

    APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

    ✓ Peer-reviewed Genetics Annals of neurology

    Key finding: Increasing cerebral Abeta deposition with age is the pathobiological phenotype of APOE4.

    Full summary, score breakdown and related studies → Original source

  14. 2010-01-01

    Amyloid PET Ligands for Dementia

    ✓ Peer-reviewed Biomarkers PET clinics

    Key finding: The increasing age of the population in developed countries suggests that, if unchecked, these disorders will become increasingly prevalent.

    Full summary, score breakdown and related studies → Original source

December 2009 11

  1. 2009-12-30

    Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization

    ✓ Peer-reviewed Mild cognitive impairment Neurology

    Key finding: The Alzheimer's Disease Neuroimaging Initiative has successfully recruited cohorts of cognitively normal subjects, subjects with mild cognitive impairment (MCI), and subjects with Alzheimer disease with anticipated baseline characteristics.

    Full summary, score breakdown and related studies → Original source

  2. 2009-12-29

    TDP-43 is a developmentally regulated protein essential for early embryonic development

    ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

    Key finding: Alteration of this multifunctional protein is associated with a number of neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin positive inclusions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2009-12-28

    Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition

    ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America

    Key finding: These findings strongly implicate APP and the betaCTF of APP, and exclude Abeta and the alphaCTF, as the cause of endocytic pathway dysfunction in DS and AD, underscoring the potential multifaceted value of BACE-1 inhibition in AD therapeutics.

    Full summary, score breakdown and related studies → Original source

  4. 2009-12-24

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    ✓ Peer-reviewed Drug development European journal of pharmacology

    Key finding: These results clearly demonstrate that Liraglutide and other GLP-1 analogues elicit effects on neurotransmission in the brain. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2009-12-23

    Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

    ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

    Key finding: Increasing evidence suggests that these degenerative synaptic changes are associated with an accumulation of soluble oligomeric assemblies of amyloid beta (Abeta) known as ADDLs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2009-12-23

    Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP

    ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular biology of the cell

    Key finding: Significantly, trisomy 21/Down syndrome patients develop early onset AD pathology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2009-12-23

    Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease

    ✓ Peer-reviewed Genetics Neurobiology of aging

    Key finding: Hippocampal atrophy has been associated with cognitive decline, but little is known about the influence of IR on hippocampus integrity in non-diabetic, cognitively intact individuals. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2009-12-23

    Cancer linked to Alzheimer disease but not vascular dementia

    ✓ Peer-reviewed Genetics Neurology

    Key finding: In white older adults, prevalent Alzheimer disease (AD) was longitudinally associated with a reduced risk of cancer, and a history of cancer was associated with a reduced risk of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2009-12-22

    Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

    ✓ Peer-reviewed Risk factors BMJ (Clinical research ed.)

    Key finding: This large cohort of 85 year olds showed good levels of both self rated health and functional ability despite significant levels of disease and impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2009-12-21

    Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

    ✓ Peer-reviewed Lewy body dementia The Journal of experimental medicine

    Key finding: FTD associated with PGRN insufficiency may result from many years of reduced neutrotrophic support together with cumulative damage in association with dysregulated inflammation.

    Full summary, score breakdown and related studies → Original source

  11. 2009-12-16

    Hippocampal changes associated with early-life adversity and vulnerability to depression

    ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

    Key finding: Smaller hippocampal volume in adolescents at high risk for depression suggests that it may be a vulnerability marker for the illness. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →