Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,976–23,000 of 27,380 studies, newest first · page 920 of 1096.
September 2006 25
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2006-09-13
Chronic psychological distress and risk of Alzheimer's disease in old age
43/100 ✓ Peer-reviewed Prevention trials Neuroepidemiology
Key finding: Clinical and pathological data from the Rush Memory and Aging Project were used to test the hypothesis that distress proneness is associated with increased risk of Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-13
Nephrologists' reported preparedness for end-of-life decision-making
44/100 ✓ Peer-reviewed End-of-life care Clinical journal of the American Society of Nephrology : CJASN
Key finding: The purpose of this study was to determine the perceived preparedness of nephrologists to make end-of-life decisions and to determine factors that are associated with the highest level of perceived preparedness. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-11
Age-dependent axonal degeneration in an Alzheimer mouse model
36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: We conclude that the intraneuronal accumulation of Abeta-amyloid peptides is followed by axonal degeneration, and thus might be a causative factor for the axonal changes seen in AD.
Full summary, score breakdown and related studies → Original source
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2006-09-11
Caregiver burden, health-related quality of life and coping in dementia caregivers: a comparison of frontotemporal dementia and Alzheimer's disease
42/100 ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders
Key finding: Overall, passive coping strategies were associated with increased burden and decreased HQoL. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-10
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
40/100 ✓ Peer-reviewed Risk genes beyond APOE Nature genetics
Key finding: Our findings link a class of proteins with unknown function and substrate specificity to the protein networks implicated in neurodegeneration and parkinsonism.
Full summary, score breakdown and related studies → Original source
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2006-09-07
Phenotype associated with APP duplication in five families
57/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: This study describes the phenotype of this new entity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-07
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation
44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry
Key finding: The Dyrk1A gene resides in the human chromosome 21q22.2 region, which is associated with DS anomalies, including mental retardation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-04
Effects of cholinergic drugs and cognitive training on dementia: 2-year follow-up
43/100 ✓ Peer-reviewed Prevention trials Dementia and geriatric cognitive disorders
Key finding: Several studies have shown that pharmacological and cognitive treatments for Alzheimers's disease improve cognitive function for short periods, but fewer studies have evaluated the efficacy of those treatments for longer (2-year) periods. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Enriched environments, experience-dependent plasticity and disorders of the nervous system
36/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Neuroscience
Key finding: Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species, and provided new insights into mechanisms of experience-dependent plasticity, including adult neurogenesis and synaptic plasticity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-01
Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients
36/100 ✓ Peer-reviewed Drug development The journal of nutrition, health & aging
Key finding: More specifically, the full genetic potential of the child for physical growth ad mental development may be compromised due to deficiency (even subclinical) of micronutrients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis
36/100 ✓ Peer-reviewed Treatments The American journal of pathology
Key finding: Experiments with amyloid-beta (Abeta)-42-immunized transgenic mouse models of Alzheimer's disease have revealed amyloid plaque disruption and apparent cognitive function recovery. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
41/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)
Key finding: Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Update on hypertension and Alzheimer's disease
36/100 ✓ Peer-reviewed Vascular contributions Neurological research
Key finding: Even though hypertension only results in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total number of demented individuals.
Full summary, score breakdown and related studies → Original source
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2006-09-01
Association of metabolic syndrome with Alzheimer disease: a population-based study
52/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: Metabolic syndrome is associated with Alzheimer disease in elderly subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Reduced hippocampal volume correlates with executive dysfunctioning in major depression
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of psychiatry & neuroscience : JPN
Key finding: The present findings emphasize that patients with reduced hippocampal volumes show more executive dysfunctions than their counterparts. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-01
Understanding the moral distress of nurses witnessing medically futile care
36/100 ✓ Peer-reviewed End-of-life care Oncology nursing forum
Key finding: Instances of futile care evoke strong emotional responses from nurses, and nurses require support in dealing with their distress. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Fracture risk after the diagnosis of Parkinson's disease: Influence of concomitant dementia
40/100 ✓ Peer-reviewed Clinical safety Movement disorders : official journal of the Movement Disorder Society
Key finding: In an inception cohort of 196 Olmsted County, Minnesota, residents with Parkinson's disease (PD) first recognized in 1976 to 1995, we tested whether the increased risk of bone fractures is associated with concomitant dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Long-term neurocognitive function after critical illness
36/100 ✓ Peer-reviewed Clinical safety Chest
Key finding: Current research indicates that neurocognitive sequelae following critical illness are common, may be permanent, and are associated with impairments in daily function, decreased quality of life, and an inability to return to work. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
41/100 ✓ Peer-reviewed Clinical safety Nature medicine
Key finding: Although there is still little evidence that inflammation triggers or promotes Alzheimer disease, increasing evidence from mouse models suggests that certain inflammatory mediators are potent drivers of the disease.
Full summary, score breakdown and related studies → Original source
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2006-09-01
Cutting Edge: TREM-2 Attenuates Macrophage Activation
53/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of Immunology
Key finding: Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation.
Full summary, score breakdown and related studies → Original source
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2006-09-01
Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT)
43/100 ✓ Peer-reviewed Cognitive tests and assessment Diabetes/metabolism research and reviews
Key finding: Type 2 diabetes is associated with cognitive dysfunction and increases the risk of dementia in the elderly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Pin1 in Alzheimer's disease
42/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurochemistry
Key finding: These observations suggest that phosphorylation events are critical to the understanding of the pathogenesis and treatment of this devastating disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-01
Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia
53/100 ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society
Key finding: Single domain nonmemory MCI and multiple domains slightly impaired MCI were associated with later development of dementia (P = 0.003; P = 0.04), whereas amnestic MCI subtype was not (P = 0.76). +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-09-01
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration
59/100 ✓ Peer-reviewed Lewy body dementia Human molecular genetics
Key finding: Both mutations revealed novel mechanisms that result in loss of functional PGRN. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-09-01
Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Epileptic disorders : international epilepsy journal with videotape
Key finding: It is clearly associated with an Alzheimer-type dementia, and may also occur in non-DS patients with Alzheimer's disease: hence the possible denomination of "senile myoclonic epilepsy". [Published with video sequences].
Full summary, score breakdown and related studies → Original source
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