Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,451–20,475 of 27,380 studies, newest first · page 819 of 1096.
November 2010 25
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2010-11-22
The mental health workforce gap in low- and middle-income countries: a needs-based approach
47/100 ✓ Peer-reviewed Caregiving Bulletin of the World Health Organization
Key finding: All low-income countries and 59% of the middle-income countries in our sample were found to have far fewer professionals than they need to deliver a core set of mental health interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-19
Increased Framingham 10-year risk of coronary heart disease in middle-aged and older patients with psychotic symptoms
48/100 ✓ Peer-reviewed Long-term cohort studies Schizophrenia research
Key finding: The Framingham 10-risk of coronary heart disease (CHD) has been a widely studied estimate of cardiovascular risk in the general population. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-19
Dementia care in rural and remote settings: a systematic review of informal/family caregiving
51/100 ✓ Peer-reviewed Disparities Maturitas
Key finding: Despite the growing body of evidence over the 20 years of this review, and the widespread interest in family dementia caregiving generally, much of the research exploring family caregiving in rural areas focuses on the experience, use and barriers to formal service provision.
Full summary, score breakdown and related studies → Original source
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2010-11-18
Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease
40/100 ✓ Peer-reviewed Brain scans and imaging PLoS computational biology
Key finding: We found that all three cortical networks exhibited small-world properties and those strong interhemispheric correlations existed between bilaterally homologous regions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-18
The relationship between neurological disease and bullous pemphigoid: a population-based case-control study
64/100 ✓ Peer-reviewed Vascular contributions The Journal of investigative dermatology
Key finding: Previous small studies and case reports have suggested that neurological disorders may be associated with bullous pemphigoid (BP). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-17
Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases
39/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: Immunocytochemical and electrophysiological studies have shown that specific binding across the synaptic cleft of the ectodomains of presynaptic NRXNs and postsynaptic neuroligins have the potential to bidirectionally coordinate and trigger synapse formation.
Full summary, score breakdown and related studies → Original source
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2010-11-16
The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Non-amyloidogenic processing of APP by α-secretases leads to proteolytic cleavage within the Aβ peptide sequence and shedding of the soluble APP ectodomain (sAPPα), which has been reported to be endowed with neuroprotective properties. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-15
Late-life depression with comorbid cognitive impairment and disability: nonpharmacological interventions
38/100 ✓ Peer-reviewed Risk factors Clinical interventions in aging
Key finding: Less than half of older adults with depression achieve remission with antidepressant medications, and rates of remission are even poorer for those with comorbid conditions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-15
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
56/100 ✓ Peer-reviewed Brain tissue and pathology PloS one
Key finding: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-12
Timing of hormone therapy and dementia: the critical window theory revisited
57/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: Although previous research has shown that initiation of postmenopausal estrogen hormone therapy (HT) in late life increases risk of dementia, animal studies and some observational studies have suggested that midlife use of HT may be beneficial; however, this has not been rigorously investigated in large population-based studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-12
Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model
44/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: SR-BI has been identified on astrocytes and vascular smooth muscle cells in Alzheimer's disease brain and has been shown to mediate adhesion of microglia to fibrillar amyloid-β (Aβ). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-12
Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography
43/100 ✓ Peer-reviewed Biomarkers Neurochemistry international
Key finding: In Alzheimer brains significantly higher binding was observed in the temporal lobes and the white matter. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-10
Physical and mental health of homebound older adults: an overlooked population
36/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Up to 3.6 million of these people are considered housebound and in need of home-based care. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-10
Strategies and innovative models for delivering palliative care in nursing homes
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: Because of the uncertain prognosis associated with chronic nonmalignant diseases such as dementia, many nursing home residents are either not referred to hospice or have very short or very long hospice stays. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-10
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease
36/100 ✓ Peer-reviewed Disease mechanisms Hippocampus
Key finding: Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-08
Delaying the onset of Alzheimer disease
52/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: We found that the bilingual patients had been diagnosed 4.3 years later and had reported the onset of symptoms 5.1 years later than the monolingual patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-08
Cerebral amyloid angiopathy pathology and cognitive domains in older persons
68/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology
Key finding: Subjects were 404 persons in the Religious Orders Study, a cohort study of aging, who underwent annual clinical evaluations, including 19 neuropsychological tests from which 5 cognitive domain and global summary scores were derived, and brain autopsy at time-of-death (mean age-at-death 86). +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-08
Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
57/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Our genome-wide search of Caribbean Hispanic individuals identified several novel genetic variants associated with LOAD and replicated these associations in a white cohort. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-04
Quality of life in nursing home residents with advanced dementia
56/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: The ADRQL is a valid indicator of QOL in NH residents with advanced dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-11-03
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old
54/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Our study showed an association between neurofibrillary pathology and frontal PVWMH and DWMH (rather than parietal), as a surrogate of small vessel disease, particularly in very old community-dwelling individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-02
Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Drug and alcohol dependence
Key finding: Lower volume in the right hippocampus in chronic cannabis users was corroborated. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
78/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Twenty-four week supplementation with 900 mg/d DHA improved learning and memory function in ARCD and is a beneficial supplement that supports cognitive health with aging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-11-01
The advanced dementia prognostic tool: a risk score to estimate survival in nursing home residents with advanced dementia
67/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: A mortality risk score derived from MDS data predicted six-month survival in advanced dementia with moderate accuracy.
Full summary, score breakdown and related studies → Original source
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2010-11-01
Palliative care needs of seriously ill, older adults presenting to the emergency department
43/100 ✓ Peer-reviewed End-of-life care Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Key finding: Seriously ill, older adults in an urban ED have substantial palliative care needs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-11-01
Prediction of 6-month survival of nursing home residents with advanced dementia using ADEPT vs hospice eligibility guidelines
60/100 ✓ Peer-reviewed End-of-life care JAMA
Key finding: When prospectively validated at the bedside and used as a continuous measure, the ability of the ADEPT score to identify nursing home residents with advanced dementia at high risk of death within 6 months was modest, albeit better than hospice eligibility guidelines.
Full summary, score breakdown and related studies → Original source
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