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Inflammation and Alzheimer's disease
Lee YJ, Han SB, Nam SY, Oh KW, Hong JT.. Archives of pharmacal research, 2010-10-30
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. Although the pathophysiologic mechanism is not fully established, inflammation appears to be involved.
Key findings
- It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals.
- Although the pathophysiologic mechanism is not fully established, inflammation appears to be involved.
- Neuroinflammation has been known to play a critical role in the pathogenesis of chronic neurodegenerative disease in general, and in AD in particular.
- Numerous studies show the presence of a number of markers of inflammation in the AD brain: elevated inflammatory cytokines and chemokines, and accumulation of activated microglia in the damaged regions.
Why it matters
This review states that inflammation appears to be involved in Alzheimer's disease and that neuroinflammation plays a critical role in its pathogenesis. It summarizes markers of inflammation and does not show that anti-inflammatory treatment cures or prevents the disease.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of pharmacal research) |
| Journal's citation record | 1 / 4 | Archives of Pharmacal Research: journal h-index 126 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 396 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.0 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 4 / 6 | Cited 16.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jin Tae Hong: h-index 74 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Chungbuk National University: institution h-index 323 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21052932) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Lee, Y. J., Han, S. B., Nam, S. Y., Oh, K. W., & Hong, J. T. (2010). Inflammation and Alzheimer's disease. Archives of pharmacal research. https://doi.org/10.1007/s12272-010-1006-7
Vancouver
Lee YJ, Han SB, Nam SY, Oh KW, Hong JT. Inflammation and Alzheimer's disease. Archives of pharmacal research. 2010. doi:10.1007/s12272-010-1006-7. PMID: 21052932.
BibTeX
@article{lee2010-21052932,
author = {Lee, Y. J. and Han, S. B. and Nam, S. Y. and Oh, K. W. and Hong, J. T.},
title = {{Inflammation and Alzheimer's disease}},
journal = {Archives of pharmacal research},
year = {2010},
doi = {10.1007/s12272-010-1006-7},
pmid = {21052932},
url = {https://doi.org/10.1007/s12272-010-1006-7}
}
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