Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,976–18,000 of 27,380 studies, newest first · page 720 of 1096.

March 2014 25

  1. 2014-03-12

    Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review

    ✓ Peer-reviewed Prevention trials Ageing research reviews

    Key finding: The results showed that combined cognitive and exercise training can be effective for improving the cognitive functions and functional status of older adults with and without cognitive impairment.

  2. 2014-03-12

    Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

    ✓ Peer-reviewed Vascular contributions Neurology

    Key finding: The small effect of VRFs and LAD on WMH suggests that WMH have a large "nonvascular," nonatheromatous etiology. +2 more findings

  3. 2014-03-12

    Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment

    ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

    Key finding: Using 182 subjects from the Alzheimer's Disease Neuroimaging Initiative we tested associations of amyloid-β with regional cerebral blood flow in healthy controls (n = 51), early (n = 66) and late (n = 41) mild cognitive impairment, and Alzheimer's disease with dementia (n = 24). +3 more findings

  4. 2014-03-12

    Incidence of cerebral microbleeds in preclinical Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: This should be considered when designing protocols for amyloid-modifying clinical trials.

  5. 2014-03-12

    Caregiver Burden: A Clinical Review

    ✓ Peer-reviewed Caregiving JAMA

    Key finding: Risk factors for caregiver burden include being female, lower education, living with the care recipient, more hours spent caregiving, depression, social isolation, financial stress, and lack of choice in becoming a caregiver +3 more findings

  6. 2014-03-11

    Association of dementia with early rehospitalization among Medicare beneficiaries

    ✓ Peer-reviewed Digital health tools Archives of gerontology and geriatrics

    Key finding: Despite growth of initiatives targeting risk factors associated with potentially avoidable hospital readmissions, the impact of dementia on the likelihood of rehospitalization is poorly characterized. +1 more finding

  7. 2014-03-11

    Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study

    ✓ Peer-reviewed Cognitive tests and assessment Molecular psychiatry

    Key finding: Sixty-nine cognitively normal (CN) controls, 52 with recently diagnosed mild cognitive impairment (MCI) and 31 with probable Alzheimer's disease (AD) dementia were included in the study. +3 more findings

  8. 2014-03-11

    Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

    ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

    Key finding: Third, there is increasing recognition of disease heterogeneity, suggesting that PD subtypes should be formally identified; however, current subtype classifications may not be sufficiently robust to warrant formal delineation.

  9. 2014-03-10

    Caregiver burden in end-of-life care: advanced cancer and final stage of dementia

    ✓ Peer-reviewed End-of-life care Palliative & supportive care

    Key finding: The percentage of psychological distress was similar between caregivers of cancer patients (77.6%) and caregivers of dementia patients (72.4%). +2 more findings

  10. 2014-03-10
  11. 2014-03-10

    Brain plasticity and motor practice in cognitive aging

    ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

    Key finding: Research suggests that human brains continuously undergo structural reorganization and functional changes in response to stimulations or training.

  12. 2014-03-10

    Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe

    ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

    Key finding: The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. +1 more finding

  13. 2014-03-10

    Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents

    ✓ Peer-reviewed Risk genes beyond APOE Journal of medicinal chemistry

    Key finding: Biological screening performed in vitro and in Escherichia coli cells has shown that these hybrids exhibit potent inhibitory activities against human acetylcholinesterase, butyrylcholinesterase, and BACE-1, dual Aβ42 and tau antiaggregating activity, and brain permeability. +3 more findings

  14. 2014-03-09

    Plasma phospholipids identify antecedent memory impairment in older adults

    ✓ Peer-reviewed Getting a diagnosis Nature medicine

    Key finding: Unfortunately, current biomarkers for early disease, including cerebrospinal fluid tau and amyloid-β levels, structural and functional magnetic resonance imaging and the recent use of brain amyloid imaging or inflammaging, are limited because they are either invasive, time-consuming or expensive. +4 more findings

  15. 2014-03-07

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    ✓ Peer-reviewed Drug development The Journal of endocrinology

    Key finding: In preclinical studies of Alzheimer's disease (AD), Parkinson's disease (PD), stroke and other neurodegenerative disorders, it has been shown that most GLP-1 mimetics cross the blood-brain barrier and show impressive neuroprotective effects in numerous studies. +1 more finding

  16. 2014-03-06

    Risk factors for incident delirium among older people in acute hospital medical units: a systematic review and meta-analysis

    ✓ Peer-reviewed Clinical safety Age and ageing

    Key finding: We aimed to synthesise data on risk factors for incident delirium and where possible conduct meta-analysis of these. +3 more findings

  17. 2014-03-06

    An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy

    ✓ Peer-reviewed Disease mechanisms PLoS genetics

    Key finding: Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia--progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD)--revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls.

  18. 2014-03-06

    Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

    ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica communications

    Key finding: Based on previous studies, a preclinical classification for Alzheimer's disease (AD) has been proposed. +3 more findings

  19. 2014-03-06

    Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). +1 more finding

  20. 2014-03-05

    Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology

    Key finding: During the last few years, targeting the endogenous cannabinoid system has emerged as a potential therapeutic approach to treat Alzheimer. +3 more findings

  21. 2014-03-05

    C9orf72 nucleotide repeat structures initiate molecular cascades of disease

    ✓ Peer-reviewed Lewy body dementia Nature

    Key finding: Our results demonstrate that distinct C9orf72 HRE structural polymorphism at both DNA and RNA levels initiates molecular cascades leading to ALS/FTD pathologies, and provide the basis for a mechanistic model for repeat-associated neurodegenerative diseases.

  22. 2014-03-05

    Contribution of Alzheimer disease to mortality in the United States

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: A larger number of deaths are attributable to AD dementia in the United States each year than the number (<84,000 in 2010) reported on death certificates.

  23. 2014-03-04

    Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease

    ✓ Peer-reviewed Treatments Nature communications

    Key finding: However, the interaction between POMs and Aβ is robust, but still needs to improve Aβ binding affinity. +4 more findings

  24. 2014-03-02

    Familial Alzheimer's disease sustained by presenilin 2 mutations: systematic review of literature and genotype-phenotype correlation

    ✓ Peer-reviewed Risk genes beyond APOE Neuroscience and biobehavioral reviews

    Key finding: Overall, the mutations involving the PSEN2 gene represent an extremely rare cause of FAD, having been reported to date in less than 200 cases.

  25. 2014-03-02

Browse the library by subject, with the full score breakdown →