Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,976–18,000 of 27,380 studies, newest first · page 720 of 1096.
March 2014 25
-
2014-03-12
Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review
64/100 ✓ Peer-reviewed Prevention trials Ageing research reviews
Key finding: The results showed that combined cognitive and exercise training can be effective for improving the cognitive functions and functional status of older adults with and without cognitive impairment.
Full summary, score breakdown and related studies → Original source
-
2014-03-12
Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities
55/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The small effect of VRFs and LAD on WMH suggests that WMH have a large "nonvascular," nonatheromatous etiology. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-12
Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment
57/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: Using 182 subjects from the Alzheimer's Disease Neuroimaging Initiative we tested associations of amyloid-β with regional cerebral blood flow in healthy controls (n = 51), early (n = 66) and late (n = 41) mild cognitive impairment, and Alzheimer's disease with dementia (n = 24). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-12
Incidence of cerebral microbleeds in preclinical Alzheimer disease
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: This should be considered when designing protocols for amyloid-modifying clinical trials.
Full summary, score breakdown and related studies → Original source
-
2014-03-12
Caregiver Burden: A Clinical Review
61/100 ✓ Peer-reviewed Caregiving JAMA
Key finding: Risk factors for caregiver burden include being female, lower education, living with the care recipient, more hours spent caregiving, depression, social isolation, financial stress, and lack of choice in becoming a caregiver +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-11
Association of dementia with early rehospitalization among Medicare beneficiaries
66/100 ✓ Peer-reviewed Digital health tools Archives of gerontology and geriatrics
Key finding: Despite growth of initiatives targeting risk factors associated with potentially avoidable hospital readmissions, the impact of dementia on the likelihood of rehospitalization is poorly characterized. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2014-03-11
Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study
56/100 ✓ Peer-reviewed Cognitive tests and assessment Molecular psychiatry
Key finding: Sixty-nine cognitively normal (CN) controls, 52 with recently diagnosed mild cognitive impairment (MCI) and 31 with probable Alzheimer's disease (AD) dementia were included in the study. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-11
Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease
56/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society
Key finding: Third, there is increasing recognition of disease heterogeneity, suggesting that PD subtypes should be formally identified; however, current subtype classifications may not be sufficiently robust to warrant formal delineation.
Full summary, score breakdown and related studies → Original source
-
2014-03-10
Caregiver burden in end-of-life care: advanced cancer and final stage of dementia
47/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: The percentage of psychological distress was similar between caregivers of cancer patients (77.6%) and caregivers of dementia patients (72.4%). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-10
Quality of dying in nursing home residents dying with dementia: does advanced care planning matter? A nationwide postmortem study
50/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: We identified 101 deaths of residents with dementia in 69 nursing homes (58% response rate). +1 more finding
Full summary, score breakdown and related studies → Original source
-
2014-03-10
Brain plasticity and motor practice in cognitive aging
40/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: Research suggests that human brains continuously undergo structural reorganization and functional changes in response to stimulations or training.
Full summary, score breakdown and related studies → Original source
-
2014-03-10
Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe
40/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2014-03-10
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of medicinal chemistry
Key finding: Biological screening performed in vitro and in Escherichia coli cells has shown that these hybrids exhibit potent inhibitory activities against human acetylcholinesterase, butyrylcholinesterase, and BACE-1, dual Aβ42 and tau antiaggregating activity, and brain permeability. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-09
Plasma phospholipids identify antecedent memory impairment in older adults
58/100 ✓ Peer-reviewed Getting a diagnosis Nature medicine
Key finding: Unfortunately, current biomarkers for early disease, including cerebrospinal fluid tau and amyloid-β levels, structural and functional magnetic resonance imaging and the recent use of brain amyloid imaging or inflammaging, are limited because they are either invasive, time-consuming or expensive. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-07
Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
36/100 ✓ Peer-reviewed Drug development The Journal of endocrinology
Key finding: In preclinical studies of Alzheimer's disease (AD), Parkinson's disease (PD), stroke and other neurodegenerative disorders, it has been shown that most GLP-1 mimetics cross the blood-brain barrier and show impressive neuroprotective effects in numerous studies. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2014-03-06
Risk factors for incident delirium among older people in acute hospital medical units: a systematic review and meta-analysis
81/100 ✓ Peer-reviewed Clinical safety Age and ageing
Key finding: We aimed to synthesise data on risk factors for incident delirium and where possible conduct meta-analysis of these. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-06
An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy
40/100 ✓ Peer-reviewed Disease mechanisms PLoS genetics
Key finding: Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia--progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD)--revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls.
Full summary, score breakdown and related studies → Original source
-
2014-03-06
Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition
57/100 ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica communications
Key finding: Based on previous studies, a preclinical classification for Alzheimer's disease (AD) has been proposed. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-06
Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study
48/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). +1 more finding
Full summary, score breakdown and related studies → Original source
-
2014-03-05
Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic
46/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology
Key finding: During the last few years, targeting the endogenous cannabinoid system has emerged as a potential therapeutic approach to treat Alzheimer. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-05
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
57/100 ✓ Peer-reviewed Lewy body dementia Nature
Key finding: Our results demonstrate that distinct C9orf72 HRE structural polymorphism at both DNA and RNA levels initiates molecular cascades leading to ALS/FTD pathologies, and provide the basis for a mechanistic model for repeat-associated neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
-
2014-03-05
Contribution of Alzheimer disease to mortality in the United States
72/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: A larger number of deaths are attributable to AD dementia in the United States each year than the number (<84,000 in 2010) reported on death certificates.
Full summary, score breakdown and related studies → Original source
-
2014-03-04
Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease
40/100 ✓ Peer-reviewed Treatments Nature communications
Key finding: However, the interaction between POMs and Aβ is robust, but still needs to improve Aβ binding affinity. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2014-03-02
Familial Alzheimer's disease sustained by presenilin 2 mutations: systematic review of literature and genotype-phenotype correlation
66/100 ✓ Peer-reviewed Risk genes beyond APOE Neuroscience and biobehavioral reviews
Key finding: Overall, the mutations involving the PSEN2 gene represent an extremely rare cause of FAD, having been reported to date in less than 200 cases.
Full summary, score breakdown and related studies → Original source
-
2014-03-02
Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people
61/100 ✓ Peer-reviewed Getting a diagnosis Age and ageing
Key finding: The 4AT is a new test for rapid screening of delirium in routine clinical practice.
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →