Newest studies

[(11)C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients

40/100 ✓ Peer-reviewed Brain scans and imaging Neurochemistry international

Key finding: Autoradiographical studies showed significantly higher densities of specific [(11)C]PIB-amyloid binding in gray matter in the temporal and parietal cortex (62fmol/mg tissue) in AD patients as compared to control subjects, whereas the density was somewhat lower in the frontal cortex (56fmol/mg tissue). +2 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Efficient colonic mucosal wound repair requires Trem2 signaling

47/100 ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: Stem cells lost because of damage or disease can be replaced by adjacent crypts that undergo fission. +3 more findings

• Genetics

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MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population

48/100 ✓ Peer-reviewed Brain scans and imaging Stroke

Key finding: Simple MRI biomarkers, in addition to their diagnostic use, have a prognostic value with respect to mortality in a memory clinic population. +1 more finding

• Brain Scans
• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

The cortical signature of prodromal AD: regional thinning predicts mild AD dementia

67/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Thinning in specific cortical areas known to be affected by Alzheimer disease (AD) is detectable in individuals with questionable AD dementia (QAD) and predicts conversion to mild AD dementia. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

62/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease

36/100 ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences of the United States of America

Key finding: Initial recruitment of leukocytes in inflammation associated with diseases such as multiple sclerosis (MS), ischemic stroke, and HIV-related dementia, takes place across intact, but activated brain endothelium.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

36/100 ✓ Peer-reviewed Genetics Journal of lipid research

Key finding: Structure/function studies revealed that apoE2 is severely defective in LDL receptor binding because of a structural difference that alters the receptor binding region and helped unravel the mechanism of type III hyperlipoproteinemia.

• Genetics

Full summary, score breakdown and related studies → Original source

(Pre)diabetes, brain aging, and cognition

45/100 ✓ Peer-reviewed Risk factors Biochimica et biophysica acta

Key finding: In fact, several studies have evidenced that phenotypes associated with obesity and/or alterations on insulin homeostasis are at increased risk for developing cognitive decline and dementia, including not only vascular dementia, but also Alzheimer's disease (AD). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

42/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of disease

Key finding: The present data indicate that long-term dietary interventions change AD-like pathology in APP/PS1 mice.

• Brain Biology
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: A subset of BACE1 localizes to cholesterol-rich membrane microdomains, termed lipid rafts. +3 more findings

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A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia

59/100 ✓ Peer-reviewed Cognitive tests and assessment The international journal of neuropsychopharmacology

Key finding: Patients were randomly assigned to group A (TJ-54 treatment in period I and no treatment in period II; each period lasting 4 wk) or group B (no treatment in period I and TJ-54 treatment in period II). +3 more findings

• Diagnosis
• Treatments

Full summary, score breakdown and related studies → Original source

Nursing time devoted to medication administration in long-term care: clinical, safety, and resource implications

41/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

Key finding: Time requirements for the medication administration process are substantial in LTC and are compounded when nurses are unfamiliar with residents.

• Treatments
• Side Effects
• Care Services

Full summary, score breakdown and related studies → Original source

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

40/100 ✓ Peer-reviewed Vascular contributions BMC neuroscience

Key finding: Intranasal insulin-like growth factor-I, deferoxamine, and erythropoietin have been shown to protect the brain against stroke in animal models. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Educating nursing home staff about the progression of dementia and the comfort care option: impact on family satisfaction with end-of-life care

36/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

Key finding: Although not significant, results as to the effectiveness of such an intervention to improve family satisfaction with end-of-life care are encouraging. +2 more findings

• End-of-Life Care
• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment

48/100 ✓ Peer-reviewed Biomarkers Stroke

Key finding: Amyloid angiopathy, associated with Alzheimer Disease (AD) causes stroke, and when even small strokes coexist with AD, they lower the threshold for dementia.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

43/100 ✓ Peer-reviewed Risk genes beyond APOE EMBO reports

Key finding: Considerable controversy surrounds whether the intracellular domain of the amyloid precursor protein (AICD) regulates expression of the Abeta-degrading metalloprotease, neprilysin (NEP). +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Neurological and psychiatric practitioners' views on Alzheimer's disease and treatment thereof

38/100 ✓ Peer-reviewed Treatments Dementia and geriatric cognitive disorders

Key finding: 36% of practitioners reported not having used therapies for medical conditions other than dementia in patients with AD for reasons of limited compliance in these patients. +4 more findings

• Treatments

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Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

51/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid beta on mitochondrial dynamics in neurons. +3 more findings

• Brain Biology

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Selective functional, regional, and neuronal vulnerability in frontotemporal dementia

36/100 ✓ Peer-reviewed Digital health tools Current opinion in neurology

Key finding: The molecular neuroscience revolution has begun to rekindle interest in fundamental neuroanatomy. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: These findings strongly support a model for Abeta effects in which low concentrations play a novel positive, modulatory role on neurotransmission and memory, whereas high concentrations play the well known detrimental effect culminating in dementia.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mitochondria in neuroplasticity and neurological disorders

36/100 ✓ Peer-reviewed Disease mechanisms Neuron

Key finding: Mitochondria are highly dynamic organelles that divide, fuse, and move purposefully within axons and dendrites. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration

36/100 ✓ Peer-reviewed Risk factors Annals of the New York Academy of Sciences

Key finding: In sum, a growing body of research suggests that a better understanding of mitochondrial fission and fusion and the regulatory factors involved may lead to improved treatments and cures for neurodegenerative diseases.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Dying with dementia in long-term care

36/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: We noted no differences between decedents with and without dementia in terms of pain, psychosocial status, family involvement, advance care planning, most life-prolonging interventions, and hospice use. +2 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Prevalence and treatment of neuropsychiatric symptoms in advanced dementia

41/100 ✓ Peer-reviewed End-of-life care Journal of gerontological nursing

Key finding: Given the high prevalence of comorbidities, associated risks for medication interactions or serious side effects, and potential low-risk benefits of psychobehavioral care, these findings raise concerns about how to best increase the provision and documentation of nonpharmacological care in advanced dementia.

• Treatments
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality

60/100 ✓ Peer-reviewed Clinical safety Critical care medicine

Key finding: The presence of burst suppression, which was unexpectedly high in this medical intensive care unit population, was an independent predictor of increased risk of death at 6 months. +4 more findings

Full summary, score breakdown and related studies → Original source