alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,851–19,875 of 27,380 studies, newest first · page 795 of 1096.

October 2011 25

  1. 2011-10-25

    CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

    ✓ Peer-reviewed Disease mechanisms Human molecular genetics

    Key finding: Forebrain-specific over-expression of human tau(P301L), a mutation associated with frontotemporal dementia with parkinsonism linked to chromosome 17, in rTg4510 mice results in the formation of NFTs, learning and memory impairment and massive neuronal death. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2011-10-25

    Synaptic dysfunction in progranulin-deficient mice

    ✓ Peer-reviewed Disease mechanisms Neurobiology of disease

    Key finding: Additionally, apical dendrites in pyramidal cells in the CA1 region of the hippocampus in GrnKO males display an altered morphology and have significantly decreased spine density compared to wild-type (WT) mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2011-10-24

    Video-telemedicine in a memory disorders clinic: evaluation and management of rural elders with cognitive impairment

    ✓ Peer-reviewed Disparities Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    Key finding: VTM is emerging as an effective way to provide consultation and care to rural residents who may not have access to specialty services and can be integrated into current clinical settings. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2011-10-21

    Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

    ✓ Peer-reviewed Drug development Frontiers in psychiatry

    Key finding: Recent studies have shown that immunotherapy clears amyloid beta (Aβ) plaques and reduces Aβ levels in mouse models of Alzheimer's disease (AD), as well as in AD patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2011-10-21

    Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

    ✓ Peer-reviewed Hippocampus size on brain scans Brain research bulletin

    Key finding: The working hypothesis is that metabolic impairment following hypoperfusion will affect neuron and glial function and result in functional damage. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2011-10-21

    What is the clinically relevant change on the ADAS-Cog?

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: 59 recruiting sites for the Alzheimer's Disease Neuroimaging Initiative. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2011-10-18

    Genome-wide association study of Alzheimer's disease with psychotic symptoms

    ✓ Peer-reviewed Genetics Molecular psychiatry

    Key finding: Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2011-10-15

    Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

    ✓ Peer-reviewed Brain tissue and pathology Journal of Neuropathology & Experimental Neurology

    Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid.

    Full summary, score breakdown and related studies → Original source

  9. 2011-10-14

    Sphingosine-1-phosphate signaling and its role in disease

    ✓ Peer-reviewed Risk factors Trends in cell biology

    Key finding: More recently, it was shown that S1P also has important intracellular targets involved in inflammation, cancer and Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2011-10-14

    High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization

    ✓ Peer-reviewed Brain scans and imaging Frontiers in neuroinformatics

    Key finding: Higher levels of accuracy, sensitivity, and specificity were achieved for gray matter (GM) volume maps (85.7, 82.9, and 90%, respectively) compared to white matter volume maps (81.1, 80.6, and 82.5%, respectively). +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2011-10-13

    Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease

    ✓ Peer-reviewed Hippocampus size on brain scans PloS one

    Key finding: The best results achieved with individual features are 90% sensitivity and 84% specificity (HC/AD classification), 64%/66% (S-MCI/P-MCI) and 82%/76% (HC/P-MCI) with the LDA classifier. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2011-10-13

    Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Biochimica et biophysica acta

    Key finding: In this review, we report the main results of clinical trials with antioxidants in mild cognitive impairment (MCI) and AD.

    Full summary, score breakdown and related studies → Original source

  13. 2011-10-12

    Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model

    ✓ Peer-reviewed Risk genes beyond APOE Biochimica et biophysica acta

    Key finding: The well-characterized transgenic Alzheimer disease (AD) mice over expressing amyloid precursor protein (APP)/Aβ (Tg mAPP) and nontransgenic (nonTg) littermates at age of 6 and 9 months were treated with Rg 1 for three months via intraperitoneal injection. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2011-10-12

    Elevation of glutathione as a therapeutic strategy in Alzheimer disease

    ✓ Peer-reviewed Mild cognitive impairment Biochimica et biophysica acta

    Key finding: Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2011-10-12

    Predicting MCI outcome with clinically available MRI and CSF biomarkers

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Incorporating quantitative assessment of learning ability along with vMRI or CSF biomarkers in the clinical workup of MCI can provide critical information on risk of imminent conversion to AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2011-10-11

    New advances in NMDA receptor pharmacology

    ✓ Peer-reviewed Vascular contributions Trends in pharmacological sciences

    Key finding: These receptors have been implicated for decades in neurological diseases such as stroke, traumatic brain injury, dementia and schizophrenia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2011-10-11

    Clinical diagnosis and management of amyotrophic lateral sclerosis

    ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology

    Key finding: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in progressive loss of bulbar and limb function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2011-10-10

    Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: Gantenerumab treatment resulted in a dose-dependent reduction in brain amyloid level, possibly through an effector cell-mediated mechanism of action.

    Full summary, score breakdown and related studies → Original source

  19. 2011-10-08

    Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Biochimica et biophysica acta

    Key finding: In this study, we tested the hypothesis that DS brains with neuropathological hallmarks of AD have more oxidative and nitrosative stress than those with DS but without significant AD pathology, as compared with similarly aged-matched non-DS controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2011-10-07

    Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

    ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration

    Key finding: APP expression misregulation can cause genetic Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2011-10-06

    Neuroinflammation in delirium: a postmortem case-control study

    ✓ Peer-reviewed Clinical safety Rejuvenation research

    Key finding: These preliminary study results show an association between human brain activity of microglia, astrocytes, and IL-6 and delirium in elderly patients and add to the accumulating evidence that inflammatory mechanisms are involved in delirium. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2011-10-05

    Effect of public deliberation on attitudes toward surrogate consent for dementia research

    ✓ Peer-reviewed Treatments Neurology

    Key finding: This sample of the older general public generally supported a policy of surrogate consent for AD research at baseline.

    Full summary, score breakdown and related studies → Original source

  23. 2011-10-05

    Age-related changes in the default mode network are more advanced in Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: The results of this study indicate that the DMN abnormalities observed in patients with AD represent an accelerated aging pattern of connectivity compared with matched controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2011-10-04

    Multi-modal multi-task learning for joint prediction of multiple regression and classification variables in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: The results on both sets of experiments demonstrate that our proposed M3T learning scheme can achieve better performance on both regression and classification tasks than the conventional learning methods.

    Full summary, score breakdown and related studies → Original source

  25. 2011-10-04

    Co-morbidity and drug treatment in Alzheimer's disease. A cross sectional study of participants in the dementia study in northern Norway

    ✓ Peer-reviewed Disparities BMC geriatrics

    Key finding: A co-morbidity score was significantly higher in AD participants compared to controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →