Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,251–20,275 of 27,380 studies, newest first · page 811 of 1096.
March 2011 6
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2011-03-01
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment
64/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Dementia due to Alzheimer disease is preceded by about 5 to 6 years of accelerated decline in multiple cognitive functions.
Full summary, score breakdown and related studies → Original source
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2011-03-01
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
61/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: In our training set, people with Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies had lower CSF α-synuclein concentrations than patients with Alzheimer's disease and other neurological disorders.
Full summary, score breakdown and related studies → Original source
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2011-03-01
Alzheimer's disease
59/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Thus, Alzheimer's disease represents a major public health concern and has been identified as a research priority. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
Vitamin D receptor gene as a candidate gene for Parkinson disease
41/100 ✓ Peer-reviewed Genetics Annals of human genetics
Key finding: In the discovery dataset, SNPs in the 5' end of VDR were associated with both risk and AAO with more significant evidence of association with AAO (P= 0.0008-0.02). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: We conclude that FHm individuals without dementia have progressive gray matter volume reductions in select AD-vulnerable brain regions, specifically the precuneus and parahippocampal gyrus. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Analysis of cross-sectional data from the AIBL study indicates that plasma apoE levels are altered in AD and correlate with AD pathology level. +4 more findings
Full summary, score breakdown and related studies → Original source
February 2011 19
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2011-02-27
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2011-02-27
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
61/100 ✓ Peer-reviewed Lewy body dementia Nature neuroscience
Key finding: Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-25
Exercise-induced myokines and their role in chronic diseases
48/100 ✓ Peer-reviewed Prevention and risk Brain, behavior, and immunity
Key finding: Accumulating data suggest that contracting skeletal muscles release myokines, which may work in a hormone-like fashion, exerting specific endocrine effects on visceral fat or mediating direct anti-inflammatory effects.
Full summary, score breakdown and related studies → Original source
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2011-02-24
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease
63/100 ✓ Peer-reviewed Cognitive tests and assessment PloS one
Key finding: In this study, we conducted a genome-wide association study in an independent set of 1034 cases and 1186 controls using the Illumina genotyping platforms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-24
Why do ethnic elders present later to UK dementia services? A qualitative study
44/100 ✓ Peer-reviewed Disparities International psychogeriatrics
Key finding: ME carer beliefs were an important barrier to early diagnosis.
Full summary, score breakdown and related studies → Original source
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2011-02-23
Social Cognition in Schizophrenia, Part 1: Performance Across Phase of Illness
57/100 ✓ Peer-reviewed Mild cognitive impairment Schizophrenia Bulletin
Key finding: Social cognitive impairments are consistently reported in schizophrenia and are associated with functional outcome. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-23
Amyloid β peptide oligomers directly activate NMDA receptors
36/100 ✓ Peer-reviewed Treatments Cell calcium
Key finding: Consistent with these findings, we observed that the increase in the cytosolic concentration of Ca(2+) induced by Aβ oligomers in cortical neurons is prevented by AP5, a broad spectrum NMDA receptor antagonist, but slightly attenuated by ifenprodil which blocks receptors with the NR2B subunit. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-23
Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort
54/100 ✓ Peer-reviewed Risk factors Sleep medicine
Key finding: These data suggest that among aged subjects with cognitive impairment and/or parkinsonism, the MSQ has adequate SN and SP for the diagnosis of RBD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-23
Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies
72/100 ✓ Peer-reviewed Risk factors Obesity reviews : an official journal of the International Association for the Study of Obesity
Key finding: Low BMI in midlife was associated with 1.96 [95% confidence interval (CI): 1.32, 2.92] times the risk of developing AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-22
Advanced care planning in care homes for older people: a qualitative study of the views of care staff and families
36/100 ✓ Peer-reviewed End-of-life care Age and ageing
Key finding: Design qualitative exploration of views from care home staff and the family of residents in care homes for older people. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-22
Apolipoprotein E in Alzheimer's disease and other neurological disorders
57/100 ✓ Peer-reviewed Genetics The Lancet Neurology
Full summary, score breakdown and related studies → Original source
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2011-02-22
White matter lesions in Parkinson disease
44/100 ✓ Peer-reviewed Caregiving Nature reviews. Neurology
Key finding: WMLs are associated with motor and cognitive symptoms in otherwise normal elderly individuals. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-19
The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease
47/100 ✓ Peer-reviewed Digital health tools European journal of nuclear medicine and molecular imaging
Key finding: PVC was shown to improve the quantitative accuracy of regional analysis performed on amyloid PET images. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-02-17
Oleuropein and derivatives from olives as Tau aggregation inhibitors
36/100 ✓ Peer-reviewed Drug development Neurochemistry international
Key finding: These findings might provide further experimental support for the beneficial nutritional properties of olives and olive oil as well as a chemical scaffold for the development of new drugs aiming at neurodegenerative tauopathies.
Full summary, score breakdown and related studies → Original source
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2011-02-17
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE
52/100 ✓ Peer-reviewed Brain tissue and pathology PLoS genetics
Key finding: The National Institute of Aging-Late Onset Alzheimer's Disease Family Study and the National Cell Repository for Alzheimer's Disease conducted a joint genome-wide association study (GWAS) of multiplex LOAD families (3,839 affected and unaffected individuals from 992 families plus additional unrelated neurologically evaluated normal subjects) using the 610 IlluminaQuad panel. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-16
Classification of primary progressive aphasia and its variants
64/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results.
Full summary, score breakdown and related studies → Original source
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2011-02-16
Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study
47/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Hippocampal atrophy and amyloid deposition seem to dissociate during the evolution of MCI, the atrophy increasing clearly and [(11)C] PiB retention changing modestly when conversion to AD occurs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-15
Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery
48/100 ✓ Peer-reviewed Clinical safety Clinical orthopaedics and related research
Key finding: Prolonged delirium was found to be associated with a poor functional outcome and increased mortality. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-02-15
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms
46/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) has been associated with decreased amyloid deposition and a reduced risk in Alzheimer disease in several epidemiological trials; however, the exact underlying molecular mechanism remains to be elucidated. +3 more findings
Full summary, score breakdown and related studies → Original source
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