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The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease
Thomas BA, Erlandsson K, Modat M, Thurfjell L, Vandenberghe R, Ourselin S, Hutton BF.. European journal of nuclear medicine and molecular imaging, 2011-02-19
Topic: Amyloid, tau and blood-test diagnosis
Results PVC was shown to improve the quantitative accuracy of regional analysis performed on amyloid PET images. Of the corrections applied, VC deconvolution demonstrated the worst recovery of grey matter values.
Key findings
- Results PVC was shown to improve the quantitative accuracy of regional analysis performed on amyloid PET images.
- Of the corrections applied, VC deconvolution demonstrated the worst recovery of grey matter values.
Why it matters
This study found that partial volume correction improved the quantitative accuracy of regional analysis on amyloid PET images, with VC deconvolution showing the worst recovery of grey matter values. It is a technical imaging methods study and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nuclear medicine and molecular imaging) |
| Journal's citation record | 2 / 4 | European Journal of Nuclear Medicine and Molecular Imaging: journal h-index 224 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 316 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 18.6 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 4 / 6 | Cited 11.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 21 other studies in this library |
| Still being cited | 3 / 4 | Cited 65 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Brian F. Hutton: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21336694) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Thomas, B. A., Erlandsson, K., Modat, M., Thurfjell, L., Vandenberghe, R., Ourselin, S., et al. (2011). The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. https://doi.org/10.1007/s00259-011-1745-9
Vancouver
Thomas BA, Erlandsson K, Modat M, Thurfjell L, Vandenberghe R, Ourselin S, et al. The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2011. doi:10.1007/s00259-011-1745-9. PMID: 21336694.
BibTeX
@article{thomas2011-21336694,
author = {Thomas, B. A. and Erlandsson, K. and Modat, M. and Thurfjell, L. and Vandenberghe, R. and Ourselin, S. and Hutton, B. F.},
title = {{The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease}},
journal = {European journal of nuclear medicine and molecular imaging},
year = {2011},
doi = {10.1007/s00259-011-1745-9},
pmid = {21336694},
url = {https://doi.org/10.1007/s00259-011-1745-9}
}
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