Apolipoprotein E in Alzheimer's disease and other neurological disorders
Philip B. Verghese, Joseph M. Castellano, David M. Holtzman. The Lancet Neurology, 2011-02-22
Topic: Amyloid, tau and blood-test diagnosis
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APA 7th
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011). Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(10)70325-2
Vancouver
Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet Neurology. 2011. doi:10.1016/s1474-4422(10)70325-2. PMID: 21349439.
BibTeX
@article{verghese2011-21349439,
author = {Verghese, Philip B. and Castellano, Joseph M. and Holtzman, David M.},
title = {{Apolipoprotein E in Alzheimer's disease and other neurological disorders}},
journal = {The Lancet Neurology},
year = {2011},
doi = {10.1016/s1474-4422(10)70325-2},
pmid = {21349439},
url = {https://doi.org/10.1016/s1474-4422(10)70325-2}
}
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Why it matters
Covers apolipoprotein E in Alzheimer's disease and other neurological disorders.
New to this subject? Start with our plain-English guide: Genetics →
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 54 of the 95 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 859 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 50.5 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 6 / 6 | Cited 44.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 119 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David M. Holtzman: h-index 206 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21349439) |
| Free to read | 2 / 2 | Free to read |
| Points | 54 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 95 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s1474-4422(10)70325-2
- PubMed: 21349439
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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