Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,001–20,025 of 27,380 studies, newest first · page 801 of 1096.
August 2011 10
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2011-08-01
Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons
16/100 ⚠ Retracted — do not rely on it Risk genes beyond APOE Cell
Key finding: Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, electrophysiological, and gene expression profiles that typify glutamatergic forebrain neurons and are competent to integrate functionally into the rodent CNS. hiN cells from familial Alzheimer disease (FAD) patients with presenilin-1 or -2 mutations exhibit altered processing and localization of amyloid precursor protein (APP) and increased production of Aβ, relative to the source patient fibroblasts or hiN cells from unaffected individuals. +1 more finding
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2011-08-01
Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
71/100 ✓ Peer-reviewed Risk factors JAMA
Key finding: Among older women, those with sleep-disordered breathing compared with those without sleep-disordered breathing had an increased risk of developing cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-01
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
72/100 ✓ Peer-reviewed How common it is Neurology
Key finding: Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline.
Full summary, score breakdown and related studies → Original source
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2011-08-01
Incidence and predictors of advance care planning among persons with cognitive impairment
45/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Only a minority of subjects initiated ACP. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-01
Ecology of the aging human brain
52/100 ✓ Peer-reviewed Caregiving Archives of neurology
Key finding: These data show an individually varying complex convergence of subclinical diseases in the brain of older CN adults. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-08-01
Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease
57/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: These findings suggest that CSF VILIP-1 and VILIP-1/Aβ42 offer diagnostic utility for early AD, and can predict future cognitive impairment in cognitively normal individuals similarly to tau and tau/Aβ42, respectively. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-01
Clinicopathological correlations in corticobasal degeneration
57/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: CBD was associated with 4 clinical syndromes: progressive nonfluent aphasia (n = 5), behavioral variant frontotemporal dementia (n = 5), executive-motor (n = 7), and posterior cortical atrophy (n = 1). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-08-01
Vitamin D: a d-lightful solution for health
42/100 ✓ Peer-reviewed Prevention and risk Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Key finding: Vitamin D deficiency during the first few years of life results in a flattened pelvis, making it difficult for childbirth. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-08-01
Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease
71/100 ✓ Peer-reviewed Treatments Archives of general psychiatry
Key finding: There was no difference between groups in time to emergence of agitation or psychosis (Cox proportional hazard ratio, 0.96; P = .88). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-01
Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease
53/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Although we did not replicate the earlier association between the APOE 3-TOMM40 haplotypes and age at onset, we observed that the polyT polymorphism is associated with risk of LOAD in APOE 33 homozygotes in a large case-control series but in the opposite direction as in the previous study. +4 more findings
Full summary, score breakdown and related studies → Original source
July 2011 15
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2011-07-30
Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI
66/100 ✓ Peer-reviewed Mild cognitive impairment Acta neuropathologica
Key finding: Previous studies of Aβ plasma as a biomarker for Alzheimer's disease (AD) obtained conflicting results. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-29
Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study
57/100 ✓ Peer-reviewed Brain tissue and pathology The Lancet Neurology
Key finding: Hippocampal sparing cases had less hippocampal atrophy than did typical and limbic-predominant cases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-28
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy
38/100 ✓ Peer-reviewed Brain tissue and pathology Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Key finding: Braak's staging concept of Lewy body disease pathogenesis is based on a spatiotemporal sequence of alpha-synuclein deposition, with autonomic nervous system involvement before synucleinopathy in substantia nigra neurons. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-28
Comorbidity profiles among patients with bullous pemphigoid: a nationwide population-based study
60/100 ✓ Peer-reviewed Costs and economics The British journal of dermatology
Key finding: Patients with BP are more likely to have various neurological diseases, schizophrenia and psoriasis prior to the diagnosis of BP, supporting associations found in other studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-28
Does hospice improve quality of care for persons dying from dementia?
40/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Bereaved family members of people with dementia who received hospice reported higher perceptions of the quality of care and quality of dying.
Full summary, score breakdown and related studies → Original source
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2011-07-28
Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment
64/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: Recent genetic and proteomic studies demonstrate that clusterin/apolipoprotein-J is associated with risk, pathology, and progression of Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-28
Predictors of caregiver burden in caregivers of individuals with dementia
52/100 ✓ Peer-reviewed Caregiving Journal of advanced nursing
Key finding: This article is a report on a study of the multidimensional predictors of caregiver burden in caregivers of individuals with dementia using nationally representative data.
Full summary, score breakdown and related studies → Original source
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2011-07-27
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
75/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Simvastatin had no benefit on the progression of symptoms in individuals with mild to moderate AD despite significant lowering of cholesterol. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-25
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
42/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: There are no motor, sensory, or coordination deficits early in the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-23
The projected effect of risk factor reduction on Alzheimer's disease prevalence
62/100 ✓ Peer-reviewed Prevention and risk The Lancet Neurology
Key finding: Together, up to half of AD cases worldwide (17·2 million) and in the USA (2·9 million) are potentially attributable to these factors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-07-23
Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia
52/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Voxel-based morphometry results revealed that atrophy in orbitofrontal/subgenual, medial prefrontal cortex and anterior temporal lobe areas covaried with total errors score of the Hayling Test. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-21
Underdiagnosis of dementia in primary care: variations in the observed prevalence and comparisons to the expected prevalence
48/100 ✓ Peer-reviewed Costs and economics Aging & mental health
Key finding: Just under a half of the expected numbers of patients with dementia are recognised in GP dementia registers. +3 more findings
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2011-07-21
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
60/100 ✓ Peer-reviewed Inflammation and the immune system Science
Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function.
Full summary, score breakdown and related studies → Original source
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2011-07-21
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
69/100 ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry
Key finding: The mean plasma total homocysteine was 30% lower in those treated with B vitamins relative to placebo. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-21
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease
57/100 ✓ Peer-reviewed Caregiving The American journal of pathology
Key finding: These results indicate that the progression of astrocytosis and microgliosis diverges from that of amyloid deposition, arguing against a straightforward relationship between glial cells and plaques. +1 more finding
Full summary, score breakdown and related studies → Original source
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