Newest studies

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

36/100 ✓ Peer-reviewed Risk factors Chemical Society reviews

Key finding: This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications.

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients

59/100 ✓ Peer-reviewed Drug development The Journal of clinical psychiatry

Key finding: The increase in gray matter volume in these areas, which various neuroimaging and postmortem neuropathology studies have implicated in the neuropathophysiology of bipolar disorder, suggests that the observed effects may be linked to clinical response. +4 more findings

• Treatments

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Classification and basic pathology of Alzheimer disease

58/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Extracellular Abeta accumulation occurs in the parenchyma as diffuse, focal or stellate deposits. +3 more findings

• Brain Biology

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

55/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

Key finding: Although this fragment shows no biological activity, its exogenous expression neither inhibits the function nor causes the sequestration of full-length nuclear TDP-43, suggesting that the 25-kDa fragment can induce cell death through a toxic gain-of-function.

• Other Dementias
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

56/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Aging

• Brain Biology

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Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: the English and Romanian Adoptees study pilot

50/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of child psychology and psychiatry, and allied disciplines

Key finding: The total grey and white matter volumes were significantly smaller in the institutionalised group compared with a group of non-deprived, non-adopted UK controls.

• Brain Scans

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Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models

36/100 ✓ Peer-reviewed Drug development FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Key finding: Through coimmunoprecipitation (co-IP), we found that alpha-Syn, pSer396/404-Tau, and p-GSK-3beta exist as a heterotrimeric complex in SH-SY5Y cells. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cannabinoids for the treatment of dementia

57/100 ✓ Peer-reviewed Inflammation and the immune system The Cochrane database of systematic reviews

Key finding: Recent studies have also shown that cannabinoids may have more specific effects in interrupting the pathological process in Alzheimer's disease. +2 more findings

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Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

45/100 ✓ Peer-reviewed Mild cognitive impairment Brain research

Key finding: Proteomics was utilized to investigate excessively HNE-bound brain proteins in EAD compared to those in control. +3 more findings

• Early Stage

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A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of clinical investigation

Key finding: TAU-induced neuronal cell death was imaged by time-lapse microscopy in vivo. +4 more findings

• Brain Biology
• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Early identification and treatment of Alzheimer's disease: social and fiscal outcomes

40/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These findings indicate that the early diagnosis and treatment of AD are not only socially desirable in terms of increasing economic efficiency, but also fiscally attractive from both state and federal perspectives. +3 more findings

• Caregiving
• Treatments
• Care Services

Full summary, score breakdown and related studies → Original source

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

36/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

Key finding: Mitochondrial Aβ has been linked to mitochondrial toxicity. +3 more findings

• Brain Biology

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A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

Key finding: Our results show that accumulation of fibrillar immunoreactivity is significantly increased in AD relative to nondemented aged subjects and those with select cognitive impairments (p < 0.0001). +2 more findings

• Brain Biology
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

64/100 ✓ Peer-reviewed Genetics Biological psychiatry

Key finding: Obesity and diabetes significantly and independently increase risk for AD. +4 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Adipose tissue dysfunction in obesity

43/100 ✓ Peer-reviewed How common it is Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Key finding: Adipocyte and adipose tissue dysfunction belong to the primary defects in obesity and may link obesity to several health problems including increased risk of insulin resistance, type 2 diabetes, fatty liver disease, hypertension, dyslipidemia, atherosclerosis, dementia, airway disease and some cancers.

• Risk Factors

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Imaging phenotypes of major depressive disorder: genetic correlates

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience

Key finding: Imaging techniques are a potentially powerful method of identifying phenotypes that are associated with, or are indicative of, a vulnerability to developing major depressive disorder (MDD). +2 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Differential memory test sensitivity for diagnosing amnestic mild cognitive impairment and predicting conversion to Alzheimer's disease

50/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Key finding: Univariate logistic regression indicated that the total learning score from the California Verbal Learning Test-II (CVLT-II) ranked highest in terms of distinguishing MCI from normal aging (sensitivity = 90.2; specificity = 84.2). +2 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Depression and dementia

38/100 ✓ Peer-reviewed Risk factors Journal of the neurological sciences

Key finding: However, recent data suggest that depression, and in particularly late-life depression, can also be a risk factor for Alzheimer's disease (AD). +1 more finding

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Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

54/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences

Fibrillar amyloid-beta (Abeta) is found in the brains of many cognitively normal older people.

• Genetics
• Early Stage

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

54/100 ✓ Peer-reviewed Genetics Nature reviews. Neuroscience

• Genetics

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Cholinesterase inhibitors and beyond

38/100 ✓ Peer-reviewed Treatments Current Alzheimer research

Key finding: The hopes and large interest raised by these drugs are well demonstrated by 12,000 references listed by PubMed under 'ChEI' for 1995-2007. +1 more finding

• Treatments

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Down syndrome--recent progress and future prospects

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Human molecular genetics

Key finding: Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia. +2 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

41/100 ✓ Peer-reviewed Disease mechanisms Science (New York, N.Y.)

Key finding: We found that nitric oxide produced in response to beta-amyloid protein, thought to be a key mediator of Alzheimer's disease, triggered mitochondrial fission, synaptic loss, and neuronal damage, in part via S-nitrosylation of dynamin-related protein 1 (forming SNO-Drp1).

• Brain Biology

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Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory

36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The recently reported human BDNF Val66Met (BDNF(Met)) polymorphism has been shown to lead to altered hippocampal volume and impaired hippocampal-dependent memory and is associated with a variety of neuropsychiatric disorders. +4 more findings

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The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychological medicine

Key finding: This study demonstrates that the impact of the BDNF Val66Met polymorphism is not confined to the hippocampus but also extends to the parahippocampal gyrus and the amygdala. +2 more findings

• Brain Scans
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source