Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,501–26,525 of 27,380 studies, newest first · page 1061 of 1096.
August 1995 7
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1995-08-01
Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy
50/100 ✓ Peer-reviewed Genetics Annals of Neurology
Key finding: We tested whether the apolipoprotein E epsilon 4 (apoE epsilon 4) allele was associated with CAA and hemorrhage and whether this association was independent of Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-08-01
Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study
55/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: After controlling for age, education, gender, and use of benzodiazepines, we found a relative risk (RR) for AD of 0.38 (0.15 to 0.95) when comparing NSAID users (n = 365) to NSAID non-users (n = 5,893). +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-08-01
Superficial siderosis of the central nervous system
47/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: The age of onset ranged from 14 to 77 years, age at death from 29 to 78 years and duration until death from 1 to 38 years excluding premature death due to the underlying cause or as a result of surgery.
Full summary, score breakdown and related studies → Original source
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1995-08-01
Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness
36/100 ✓ Peer-reviewed Clinical safety Brain and cognition
Key finding: Lewy body dementia is also associated with a disturbance in cholinergic transmission; neocortical cholinergic deficits in this disorder are more extensive than in Alzheimer's disease and are correlated with symptoms commonly associated with delirium, such as visual hallucinations. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-08-01
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
59/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: Cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence similarity to the S182 gene on chromosome 14q24.3. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-08-01
Glial cytokines in Alzheimer's disease: review and pathogenic implications
46/100 ✓ Peer-reviewed Inflammation and the immune system Human pathology
Key finding: Interleukin-1 (IL-1), a microglia-derived acute phase cytokine, activates astrocytes and induces expression of the astrocyte-derived cytokine, S100 beta, which stimulates neurite growth (and thus has been implicated in neuritic plaque formation) and increases intracellular free calcium levels. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-08-01
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors
45/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: This relationship has been demonstrated in human glioma and neuroblastoma cells, as well as in transfected human embryonic kidney 293 cells and PC-12 cells. +3 more findings
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July 1995 6
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1995-07-01
A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET
43/100 ✓ Peer-reviewed Vascular contributions Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: 3D-SSP enables quantitative data extraction and reliable localization of metabolic abnormalities by means of stereotactic coordinates. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-07-01
VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: A significant decrease in the number of VIP expressing neurons in the SCN was found in female presenile AD patients, i.e., those younger than 65 years.
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1995-07-01
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: These findings are consistent with a smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory. +4 more findings
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1995-07-01
Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents
60/100 ✓ Peer-reviewed Clinical safety American journal of epidemiology
Key finding: Although psychotropic drug use has been associated with increased risk of falls in long-term care settings; this association may be confounded by the high prevalence of dementia and depression and other fall risk factors. +3 more findings
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1995-07-01
Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain
43/100 ✓ Peer-reviewed Inflammation and the immune system Neurochemistry international
Key finding: Isolated human microglia placed in contact with plaques in vitro are activated to release a factor which is toxic to neurons. +2 more findings
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1995-07-01
ApoE immunoreactivity and microglial cells in Alzheimer's disease brain
45/100 ✓ Peer-reviewed Genetics Neuroscience letters
Key finding: These data suggest that microglial cells play a more significant role than astrocytes in apoE deposition in senile plaques of Alzheimer disease.
Full summary, score breakdown and related studies → Original source
June 1995 10
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1995-06-01
Cigarette smoking and protection from Parkinson's disease
40/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Although the majority indicated an approximate halving of smoking frequency in persons with Parkinson's disease, many observers have suggested that the effect could be a spurious result.
Full summary, score breakdown and related studies → Original source
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1995-06-01
Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
43/100 ✓ Peer-reviewed Biomarkers Annals of neurology
Key finding: Using immunohistochemistry and immunofluorescent labeling in conjunction with laser scanning confocal microscopy, we observed intense immunoreactivity of heme oxygenase-1 in neurons of the hippocampus and temporal cortex of Alzheimer-diseased (AD) brain relative to age-matched control specimens. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-06-01
Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients
50/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: Cerebral cortical dysgenesis (CD) is a heterogeneous disorder of cortical development and organization commonly associated with epilepsy, with a variety of subtypes. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-06-01
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
64/100 ✓ Peer-reviewed Genetics Nature
Key finding: One of these transcripts (S182) corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein. +2 more findings
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1995-06-01
Cognitive impairment in the nondemented elderly. Results from the Canadian Study of Health and Aging
58/100 ✓ Peer-reviewed Brain tissue and pathology Archives of neurology
Key finding: Study objective To describe a population that was categorized as "cognitively impaired not demented" (CIND) and to examine the utility of some of the proposed criteria for describing this degree of cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-06-01
Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein
44/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Transgenic mice expressing the 751-amino acid isoform of human beta-APP (beta-APP751) have been shown to develop early AD-like histopathology with diffuse deposits of beta-A4 and aberrant tau protein expression in the brain, particularly in the hippocampus, cortex, and amygdala. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-06-01
Role of increased cerebral myo-inositol in the dementia of Down syndrome
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Magnetic resonance in medicine
Key finding: The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-06-01
The prevalence of dementia and depression in the elderly community in a southern European population. The Zaragoza study
41/100 ✓ Peer-reviewed Disparities Archives of general psychiatry
Key finding: Among the elderly, the prevalence of Alzheimer's disease and multi-infarct dementia, as opposed to depression, increases steeply with age. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-06-01
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study
56/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Multivariate analysis showed that age, prior stroke episodes, systolic blood pressure, and alcohol consumption were significant independent risk factors for the occurrence of VD. +1 more finding
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1995-06-01
Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders
37/100 ✓ Peer-reviewed Biomarkers Neuroscience letters
Key finding: An anti-tau monoclonal antibody tau-2 was demonstrated to react with the cells which characteristically appeared in the subcortical nuclei of certain neurodegenerative disorders.
Full summary, score breakdown and related studies → Original source
May 1995 2
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1995-05-01
A hindi version of the MMSE: The development of a cognitive screening instrument for a largely illiterate rural elderly population in india
34/100 ✓ Peer-reviewed Risk factors International Journal of Geriatric Psychiatry
Key finding: Systematic, item‐by‐item, empirically based test development has shown that effective modifications can be made to existing tests that require reading and writing; and that culturally sensitive modifications can be made to render the test meaningful and relevant while still tapping the appropriate cognitive domains.
Full summary, score breakdown and related studies → Original source
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1995-05-01
Anticholinesterases: medical applications of neurochemical principles
36/100 ✓ Peer-reviewed Risk factors Journal of neurochemistry
Key finding: Poisoning by such compounds can result in an acute but usually manageable medical crisis and may damage the CNS and the PNS, as well as cardiac and skeletal muscle tissue.
Full summary, score breakdown and related studies → Original source
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