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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,176–20,200 of 27,380 studies, newest first · page 808 of 1096.

April 2011 25

  1. 2011-04-13

    Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse

    ✓ Peer-reviewed Disease mechanisms Neurobiology of aging

    Key finding: In fact, overall phosphorylation of tau was reduced, perhaps due to reduced microtubule binding.

    Full summary, score breakdown and related studies → Original source

  2. 2011-04-13

    Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: VRF increased the risk of incident AD dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2011-04-13

    Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

    ✓ Peer-reviewed Caregiving Brain : a journal of neurology

    Key finding: We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorodeoxyglucose-positron emission tomography. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2011-04-13

    Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: AD-signature cortical thinning in CN-AD converters in both samples was remarkably similar, about 0.2 mm (p 1). +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2011-04-12

    Corticobasal degeneration: a pathologically distinct 4R tauopathy

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Neurology

    Key finding: It is associated with heterogeneous motor, sensory, behavioral and cognitive symptoms, which make its diagnosis difficult in a living patient. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2011-04-11

    Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation

    ✓ Peer-reviewed Drug development The Journal of biological chemistry

    Key finding: A variety of genetic and biochemical evidence suggests that amyloid β (Aβ) oligomers promote downstream errors in Tau action, in turn inducing neuronal dysfunction and cell death in Alzheimer and related dementias. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2011-04-11

    Lack of evidence for the efficacy of memantine in mild Alzheimer disease

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: Summary results for patients with mild AD were obtained by contrasting the summary results for patients with mild or moderate AD with the summary results for the subset of patients with moderate AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2011-04-08

    Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

    Key finding: 81 participants with probable Alzheimer's disease and 69 healthy controls were assessed.

    Full summary, score breakdown and related studies → Original source

  9. 2011-04-06

    Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

    ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology

    Key finding: The goal of this study was to investigate the role of endogenous amyloid-β peptide (Aβ) in healthy brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2011-04-06

    Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: The phosphorylation of occludin at Thr residues and the activation of protein kinase C (PKC)η in mBECs were attenuated in the apoE4-BBB model compared with those in the apoE3-BBB model. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2011-04-05

    Identification of a blood-based biomarker panel for classification of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers The international journal of neuropsychopharmacology

    Key finding: In conclusion, we identified a panel of three blood markers, which allowed SVM-based distinguishing of AD patients from healthy controls on a single-subject classification level with clinically relevant accuracy and validity.

    Full summary, score breakdown and related studies → Original source

  12. 2011-04-03

    Increased plasma levels of lipocalin 2 in mild cognitive impairment

    ✓ Peer-reviewed Inflammation and the immune system Journal of the neurological sciences

    Key finding: MCI represents a prodromal stage of AD, and inflammation occurs as one of the earliest pathological events in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2011-04-03

    Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Nature Genetics

    Key finding: Three SNPs at two loci replicated and showed evidence for association in a further sample. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2011-04-03

    Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)).

    Full summary, score breakdown and related studies → Original source

  15. 2011-04-01

    Coffee and its consumption: benefits and risks

    ✓ Peer-reviewed Risk factors Critical reviews in food science and nutrition

    Key finding: Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumption revealed its inverse correlation with that of diabetes mellitus, various cancer lines, Parkinsonism, and Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2011-04-01

    Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia

    ✓ Peer-reviewed Prevention trials Neurology

    Key finding: Comorbid frontotemporal dementia is a negative prognostic indicator. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2011-04-01

    Central auditory dysfunction as a harbinger of Alzheimer dementia

    ✓ Peer-reviewed Vascular contributions Archives of otolaryngology--head & neck surgery

    Key finding: Central auditory dysfunction is a precursor to AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2011-04-01

    The neuronal transporter gene SLC6A15 confers risk to major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Neuron

    Key finding: Risk allele carrier status in humans and chronic stress in mice were associated with a downregulation of the expression of this gene in the hippocampus, a brain region implicated in the pathophysiology of MD.

    Full summary, score breakdown and related studies → Original source

  19. 2011-04-01

    Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease

    ✓ Peer-reviewed Disease mechanisms The European journal of neuroscience

    Key finding: After p-Tau formation, both Tau and microtubule-associated protein 1 (MAP1) dissociated from the cytoskeleton, consistent with the diminished ability of these cytoskeleton-binding proteins to bind microtubules. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2011-04-01

    The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: The incretin hormone glucagon-like peptide-1 (GLP-1) facilitates insulin signaling, and novel long-lasting GLP-1 analogs, such as liraglutide, are on the market as diabetes therapeutics. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2011-04-01

    Cognitive decline in patients with dementia as a function of depression

    ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: There is evidence that major depression increases the risk for dementia, but there is conflicting evidence as to whether depression may accelerate cognitive decline in dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2011-04-01

    Four sensitive screening tools to detect cognitive dysfunction in geriatric emergency department patients: brief Alzheimer's Screen, Short Blessed Test, Ottawa 3DY, and the caregiver-completed AD8

    ✓ Peer-reviewed Cognitive tests and assessment Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    Key finding: Cognitive dysfunction, including dementia and delirium, is prevalent in geriatric emergency department (ED) patients, but often remains undetected. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2011-04-01

    Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2011-04-01

    Alzheimer's disease: the challenge of the second century

    ✓ Peer-reviewed How common it is Science translational medicine

    Key finding: Current information suggests that if the disease is detected before the onset of overt symptoms, it is possible that treatments based on knowledge of underlying pathogenesis can and will be effective.

    Full summary, score breakdown and related studies → Original source

  25. 2011-04-01

    A randomized controlled trial of an activity specific exercise program for individuals with Alzheimer disease in long-term care settings

    ✓ Peer-reviewed Treatments Journal of geriatric physical therapy (2001)

    Key finding: Subjects receiving the activity specific exercise program improved in ability to perform transfers, whereas subjects in the other 2 groups declined. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →