Newest studies

Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia

40/100 ✓ Peer-reviewed Drug development Acta neuropathologica

Key finding: Clinical and neuropsychological studies of chronically institutionalized patients with schizophrenia indicate that severe cognitive impairment and functional disability in late life are very prevalent. +3 more findings

• Brain Biology

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

36/100 ✓ Peer-reviewed Genetics Annual review of medicine

Key finding: A major susceptibility locus, apolipoprotein E (APOE, gene; apoE, protein) is associated with risk and age of onset distributions for the common familial and sporadic late-onset AD.

• Genetics

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Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984)

52/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: After the first year, a 50% increase was observed in Alzheimer's disease in the cohort compared with that in the community. +1 more finding

• Risk Factors

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Relationship between falls and stride length variability in senile dementia of the Alzheimer type

43/100 ✓ Peer-reviewed Clinical safety Gerontology

Key finding: The findings indicated that the number of fallers was significantly higher in moderate-stage SDAT patients than in the mild-stage patients. +3 more findings

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Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes

43/100 ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America

Key finding: Induction depended on productive viral infection: not only did the kinetics of MIP-1 peptide induction closely follow those of viral replication, but monocyte cultures inoculated with heat-inactivated virus or infected in the presence of AZT failed to produce these chemokine beta peptides. +3 more findings

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Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP

49/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America

Key finding: In this disorder, the vascular amyloid in tissue sections and the approximately 7.5-kDa fragment extracted from amyloid are labeled by antibodies to epitopes located in the PrP sequence including amino acids 90-147. +3 more findings

• Brain Biology
• Genetics

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Medical comorbidity in schizophrenia

42/100 ✓ Peer-reviewed Brain tissue and pathology Schizophrenia bulletin

Key finding: Patients with comorbid conditions are usually excluded from research studies, although they probably represent the majority of individuals with schizophrenia. +3 more findings

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Effect of tacrine on behavioral symptoms in Alzheimer's disease: an open-label study

42/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of geriatric psychiatry and neurology

Key finding: Twenty-eight subjects completed a baseline evaluation and at least one assessment during treatment. +3 more findings

• Clinical Trials
• Diagnosis

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Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease

40/100 ✓ Peer-reviewed Risk genes beyond APOE Brain research. Molecular brain research

Key finding: This has not been directly examined in human brain vascular tissues. +3 more findings

• Brain Biology

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Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man

44/100 ✓ Peer-reviewed Lewy body dementia Journal of neural transmission (Vienna, Austria : 1996)

Key finding: The partial elucidation of the processes underlie the selective action of neurotoxic substances such as 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), has however revealed possible molecular mechanisms that give rise to neuronal death. +1 more finding

• Other Dementias

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Down syndrome with partial duplication and del (21) syndrome: study protocol and call for collaboration. Study I: Clinical assessment

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Clinical genetics

Key finding: We report on the clinical and cytogenetic assessment of five cases of Down syndrome phenotype with either a partial duplication of chromosome 21 or a normal karyotype, and we quote a case of del (21q) syndrome. +4 more findings

• Down Syndrome

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Endogenous opioids in frontal cortex of patients with Down syndrome

33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

Key finding: The results of this study show that there is an increase in the levels of leu-enkephalin and dynorphin A in the frontal cortex of patients with DS as compared to the control group. +1 more finding

• Down Syndrome

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Modulation of blood-brain barrier permeability

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of drug targeting

Key finding: Genetic and other defects leading to brain changes in Down syndrome, Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, Gaucher disease, hypertension and other disorders are rapidly being identified. +2 more findings

• Brain Biology

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Prevalence of dementia in adults with and without Down syndrome

38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of mental retardation : AJMR

Key finding: No significant differences were found between adults under 50 years of age with and without Down syndrome. +1 more finding

• Down Syndrome

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Word-finding deficits persist after left anterotemporal lobectomy

39/100 ✓ Peer-reviewed Digital health tools Archives of neurology

Key finding: Differences between these results and those of previous studies may reflect differences in extent of surgical resection and/or differential sensitivity of psychometric measures of naming to word-finding problems. +1 more finding

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Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts

41/100 ✓ Peer-reviewed How common it is European neurology

Key finding: Cerebral atrophy (CA) in stroke patients is associated with poststroke dementia and may reflect underlying neurodegenerative pathology. +2 more findings

• Brain Scans

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Clinical features of frontal lobe dementia in comparison to Alzheimer's disease

54/100 ✓ Peer-reviewed Disparities Journal of neural transmission. Supplementum

Key finding: In addition, we shall describe the results of retrospective and prospective neuropsychiatric studies of a group of DFT patients.

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Cognitive test performance in a community-based nondemented elderly sample in rural India: the Indo-U.S. Cross-National Dementia Epidemiology Study

41/100 ✓ Peer-reviewed Disparities International psychogeriatrics

Key finding: An age-stratified random sample of men and women, aged 55 years and older, was drawn from a community-based population in the rural area of Ballabgarh in northern India. +4 more findings

• Health Equity
• Diagnosis

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Performance of the dementia severity rating scale: a caregiver questionnaire for rating severity in Alzheimer disease

40/100 ✓ Peer-reviewed Caregiving Alzheimer disease and associated disorders

Key finding: The DSRS provides a simple, valid, and sensitive measure of impairment associated with AD.

• Caregiving

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The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery

45/100 ✓ Peer-reviewed Getting a diagnosis European neurology

Key finding: This study aimed at investigating the clinical usefulness of the Mental Deterioration Battery (MDB) in the neuropsychological diagnosis and characterization of the dementia syndrome.

• Diagnosis

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Is a randomized trial of antioxidants in the primary prevention of Alzheimer disease warranted?

35/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: Laboratory studies suggest that oxidative mechanisms may be involved in the pathogenesis of Alzheimer disease and raise the possibility that antioxidant nutrients could be used in disease prevention. +2 more findings

• Clinical Trials
• Prevention

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Rationale and design of a multicenter study of selegiline and alpha-tocopherol in the treatment of Alzheimer disease using novel clinical outcomes. Alzheimer's Disease Cooperative Study

56/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

Key finding: The primary outcome of the study is the time to reach any one of the following four endpoints: death, institutionalization, loss of two of three basic activities of daily living, and progression of Clinical Dementia Rating (CDR) stage from 2 to 3. +4 more findings

• Treatments
• Clinical Trials

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Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions

36/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: A congenic pair was used: the C5-sufficient (C5+) B10.D2/nSnJ strain with the functional allele (Hc1) from the C57BL/10J donor strain was compared with the C5-deficient (C5-) B10.D2/oSnJ with the Hc0 allele from the C5-deficient DBA/2J donor strain. +2 more findings

• Brain Biology
• Genetics

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Apolipoprotein E, synaptic plasticity and Alzheimer's disease

38/100 ✓ Peer-reviewed Genetics Annals of medicine

Key finding: Entorhinal cortex-lesioned rats have been used extensively to examine the molecular mechanisms associated with deafferentation and reinnervation in the CNS; studies of the role of apoE in this process using this animal model are described. +2 more findings

• Genetics

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature

Key finding: Development of the DS brain is associated with decreased neuronal number and abnormal neuronal differentiation, and adults with DS develop Alzheimer's disease. +1 more finding

• Down Syndrome
• Brain Biology

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