Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,676–17,700 of 27,380 studies, newest first · page 708 of 1096.
August 2014 25
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2014-08-14
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates
54/100 ✓ Peer-reviewed Lewy body dementia Nature protocols
Key finding: This model allows investigation of aggregate formation, their impact on neuron function, and development of therapeutics. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-13
Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease
43/100 ✓ Peer-reviewed Biomarkers ACS chemical neuroscience
Key finding: We used an immunomagnetic reduction assay to measure the plasma levels of Aβ40, Aβ42, and tau proteins in 20 older control participants and 25 participants who had either mild cognitive impairment due to AD or early AD dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-13
The pattern and loci of training-induced brain changes in healthy older adults are predicted by the nature of the intervention
41/100 ✓ Peer-reviewed Prevention trials PloS one
Key finding: The few studies that have looked at brain correlates of cognitive training indicate a variable pattern and location of brain changes--a result that might relate to differences in training formats.
Full summary, score breakdown and related studies → Original source
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2014-08-13
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
50/100 ✓ Peer-reviewed Digital health tools Gerontology
Key finding: The fall detection system detected 12 out of 15 real-life falls, having a sensitivity of 80.0%, with a false alarm rate of 0.049 alarms per usage hour with the implemented real-time system. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-13
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease
48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Moreover, we found, in either the whole AD population or both subgroups, a CSF profile in which higher +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-12
Increased risk of dementia in patients exposed to nitrogen dioxide and carbon monoxide: a population-based retrospective cohort study
52/100 ✓ Peer-reviewed Risk factors PloS one
Key finding: The results of this large retrospective, population-based study indicate that exposure to NO2 and CO is associated with an increased risk of dementia in the Taiwanese population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-12
Plasma DYRK1A as a novel risk factor for Alzheimer's disease
47/100 ✓ Peer-reviewed Biomarkers Translational psychiatry
Key finding: In plasma from AD patients, DYRK1A levels were significantly lower compared with controls (P<0.0001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-12
MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease
40/100 ✓ Peer-reviewed Genetics Molecular medicine reports
Key finding: In the present study, bioinformatic analyses showed that miR‑193b was a miR that was predicted to potentially target the 3'‑untranslated region (UTR) of APP. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-11
Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis
52/100 ✓ Peer-reviewed Vascular contributions Ageing research reviews
Key finding: Large cohort studies have revealed a relationship among increased risk for cognitive impairment and dementia in cardiovascular diseases probably due to embolic stroke or chronic cerebral hypoperfusion.
Full summary, score breakdown and related studies → Original source
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2014-08-11
Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity
40/100 ✓ Peer-reviewed TREM2 and immune genetics Diabetes
Key finding: However, the role of TREM2 in adipogenesis or obesity has not yet been defined. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-08
Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Neuropharmacology
Key finding: We have previously shown that liraglutide showed neuroprotective effects in the APPswe/PS1ΔE9 mouse model of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-07
Using virtual reality for cognitive training of the elderly
36/100 ✓ Peer-reviewed Prevention trials American journal of Alzheimer's disease and other dementias
Key finding: Meeting that demand can significantly benefit from the deployment of innovative, computer-based applications capable of addressing specific needs, particularly in the area of cognitive impairment mitigation and rehabilitation.
Full summary, score breakdown and related studies → Original source
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2014-08-07
Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients
43/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica communications
Key finding: Little is known, however, about the different phenotypes of microglia and how they change during disease progression, in the SN or in another brain region, like the hippocampus (HC), which is implicated in dementia and depression, important non-motor symptoms in PD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-07
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
58/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)
Key finding: Expression of individual dipeptide repeat proteins with a non-GGGGCC RNA sequence revealed that both poly-(glycine-arginine) and poly-(proline-arginine) proteins caused neurodegeneration. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-08-06
Vitamin D and the risk of dementia and Alzheimer disease
52/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-06
Pathological alpha-synuclein propagates through neural networks
43/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica communications
Key finding: α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, so-called α-synucleinopathies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-05
Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression
50/100 ✓ Peer-reviewed Digital health tools Molecular psychiatry
Key finding: Our aim was to evaluate peripheral (blood-based) evidence for biological pathways associated with cognitive impairment in older adults with LLD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-04
Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease
38/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: CSF α-syn and Aβ₁₋₄₂ were significantly lower in PD compared with controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-04
Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults
67/100 ✓ Peer-reviewed Hippocampus size on brain scans Frontiers in aging neuroscience
Key finding: Cardiovascular activity has been shown to be positively associated with gray and white matter volume of, amongst others, frontal and temporal brain regions in older adults. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-04
Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease
48/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in cellular neuroscience
Key finding: It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-04
Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease
41/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: APOE-e4 associated with worse baseline memory and increased decline with highly significant overall effect on memory. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-08-01
Efficacy and safety studies of gantenerumab in patients with Alzheimer's disease
38/100 ✓ Peer-reviewed Treatments Expert review of neurotherapeutics
Key finding: Among active and passive anti-β-amyloid (Aβ) immunotherapies for Alzheimer's disease (AD), bapineuzumab and solanezumab, two humanized monoclonal antibodies, failed to show significant clinical benefits in mild-to-moderate AD patients in large Phase III clinical trials. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-08-01
Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk
38/100 ✓ Peer-reviewed Genetics ACS chemical neuroscience
Key finding: Our data suggest that haptoglobin and ApoE functions in brain should be evaluated taking into account their mutual interaction with beta-amyloid.
Full summary, score breakdown and related studies → Original source
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2014-08-01
Multiple chronic conditions and life expectancy: a life table analysis
64/100 ✓ Peer-reviewed Costs and economics Medical care
Key finding: Social Security and Medicare actuaries should account for the growing number of beneficiaries with multiple chronic conditions when determining population projections and trust fund solvency. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-08-01
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice
36/100 ✓ Peer-reviewed Drug development Journal of neurochemistry
Key finding: These results show that passive immunization targeting tau can modulate aspects of tau pathology in tau transgenic mouse models, in an antibody isotype-specific manner.
Full summary, score breakdown and related studies → Original source
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