Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,551–19,575 of 27,380 studies, newest first · page 783 of 1096.
April 2012 14
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2012-04-01
Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension
36/100 ✓ Peer-reviewed Clinical safety The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: The SFO mediates the dysfunction via two signaling pathways. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly
43/100 ✓ Peer-reviewed Clinical safety Anesthesiology
Key finding: This is the first prospective study employing validated measures of delirium to identify an association between preexisting obstructive sleep apnea and postoperative delirium. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Mediterranean diet and longevity in Sicily: survey in a Sicani Mountains population
43/100 ✓ Peer-reviewed Prevention trials Rejuvenation research
Key finding: Over the past several years, increasing evidence suggests that the Mediterranean diet has a beneficial influence on several age-related diseases, showing protective effect on health and longevity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-04-01
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
36/100 ✓ Peer-reviewed Disease mechanisms Autophagy
Key finding: Incubation with nanomolar concentrations of MB was sufficient to significantly reduce levels of tau both in organotypic brain slice cultures from a mouse model of FTD, and in cell models. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease
54/100 ✓ Peer-reviewed Cognitive tests and assessment Annals of neurology
Key finding: Rapid eye movement sleep behavior disorder (RBD) is common in Parkinson disease (PD), but its relationship to the varied neurotransmitter deficits of PD and prognostic significance remain incompletely understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
55/100 ✓ Peer-reviewed Risk genes beyond APOE Cell
Key finding: We studied human amyloid precursor protein (hAPP) transgenic mice, which simulate key aspects of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
The neuropsychological profile of Alzheimer disease
49/100 ✓ Peer-reviewed Lewy body dementia Cold Spring Harbor perspectives in medicine
Key finding: Neuropsychological assessment has featured prominently over the past 30 years in the characterization of dementia associated with Alzheimer disease (AD).
Full summary, score breakdown and related studies → Original source
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2012-04-01
Fecal corticosterone levels in RCAN1 mutant mice
30/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Comparative medicine
Key finding: We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Brain imaging in Alzheimer disease
53/100 ✓ Peer-reviewed Getting a diagnosis Cold Spring Harbor perspectives in medicine
Key finding: Initially, computed tomography (CT) and then magnetic resonance imaging (MRI) were used diagnostically to rule out other causes of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010
64/100 ✓ Peer-reviewed Getting a diagnosis Journal of neuropathology and experimental neurology
Key finding: Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study design
56/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: This study will provide clinically relevant data on the likelihood and time to relapse, and predictors of relapse, in patients switched from risperidone to placebo after response to risperidone treatment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-04-01
Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial
54/100 ✓ Peer-reviewed Treatments Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Key finding: Studies have shown that donepezil could reduce the AD assessment scale-cognitive subscale (ADAS-Cog) score in MCI patients and improve the patient's attention and speed of response; however, it also has many side effects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-04-01
Three-week nutritional supplementation effect on long-term nutritional status of patients with mild Alzheimer disease
52/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Intervention resulted in significant improvements in Mini Nutritional Assessment (MNA) score [Mean=1.4, standard deviation (SD)=0.8 vs. 0.0 (0.1) in the control group, P<0.001] and also in anthropometrical and serum biomarkers of Alzheimer disease (AD) patients' nutritional status. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-04-01
Recruitment strategies for preventive trials. The MAPT study (MultiDomain Alzheimer Preventive Trial)
59/100 ✓ Peer-reviewed Treatments The journal of nutrition, health & aging
Key finding: Interestingly, the higher percentage of randomizations compared to screened participants is the personal contact source; almost 85 % of screened participants entered in the study.
Full summary, score breakdown and related studies → Original source
March 2012 11
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2012-03-30
NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain
36/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: This paper introduces neurite orientation dispersion and density imaging (NODDI), a practical diffusion MRI technique for estimating the microstructural complexity of dendrites and axons in vivo on clinical MRI scanners.
Full summary, score breakdown and related studies → Original source
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2012-03-30
Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Neurochemical research
Key finding: Previously, we demonstrated increased oxidative damage and lowered antioxidant function in substantia nigra during aging making it vulnerable to degeneration associated with Parkinson's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-30
Teaching an adult brain new tricks: a critical review of evidence for training-dependent structural plasticity in humans
36/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: A growing number of structural neuroimaging studies have reported significant changes in gray matter density or volume and white matter microstructure in the adult human brain following training. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-29
Trans-cellular propagation of Tau aggregation by fibrillar species
51/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: Aggregation of the microtubule associated protein Tau is associated with several neurodegenerative disorders, including Alzheimer disease and frontotemporal dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-28
Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study
60/100 ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society
Key finding: Long-term use of sulfonylureas, thiazolidinediones, or insulin was not associated with an altered risk of developing AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-28
Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial
58/100 ✓ Peer-reviewed Treatments Neurorehabilitation and neural repair
Key finding: LSS treatment may improve episodic memory in AD patients and may be regarded as a clinical option to counteract the cognitive decline typical of the disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-03-23
Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
40/100 ✓ Peer-reviewed Drug development BMC neuroscience
Key finding: Our results suggest that these novel incretin analogues cross the BBB and show physiological activity and neurogenesis in the brain, which may be of use as a treatment of neurodegenerative diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-23
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET
55/100 ✓ Peer-reviewed Mild cognitive impairment European journal of nuclear medicine and molecular imaging
Key finding: A significant increase in global cortical [(11)C]PIB BP(ND) was found in MCI patients, but no changes were observed in AD patients or controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-22
Predicting future clinical changes of MCI patients using longitudinal and multimodal biomarkers
58/100 ✓ Peer-reviewed Mild cognitive impairment PloS one
Key finding: The results on both sets of experiments show that our proposed method can achieve better performance in predicting future clinical changes of MCI patients than the conventional methods.
Full summary, score breakdown and related studies → Original source
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2012-03-21
Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
46/100 ✓ Peer-reviewed Mild cognitive impairment Progress in neurobiology
Key finding: The concepts derived from the β-amyloid hypothesis support β-amyloid as a conductor in the pathogenesis of familial AD and as a prodding factor in sporadic AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-03-21
Prefrontal cortex rTMS enhances action naming in progressive non-fluent aphasia
42/100 ✓ Peer-reviewed Digital health tools European journal of neurology
Key finding: Our study demonstrated that rTMS improved action naming in subjects with PNFA, possibly due to the modulation of DLPFC pathways and a facilitation effect on lexical retrieval processes. +2 more findings
Full summary, score breakdown and related studies → Original source
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