Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,151–20,175 of 27,380 studies, newest first · page 807 of 1096.
May 2011 1
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2011-05-01
Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Neurology
Key finding: One third of patients with pathologic confirmed EOAD presented with atypical symptoms. +2 more findings
Full summary, score breakdown and related studies → Original source
April 2011 24
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2011-04-30
Inflammation induced by infection potentiates tau pathological features in transgenic mice
36/100 ✓ Peer-reviewed Drug development The American journal of pathology
Key finding: Researchers have recently demonstrated that triggering inflammation in the brain exacerbates tau pathological characteristics in animal models. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-29
Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis
64/100 ✓ Peer-reviewed Hippocampus size on brain scans The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Key finding: Several magnetic resonance imaging studies have reported hippocampal volume reduction in patients with schizophrenia, but other studies have reported contrasting results. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-04-29
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease
16/100 ⚠ Retracted — do not rely on it Lewy body dementia PloS one
Key finding: Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). +3 more findings
Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2011-04-27
CSF biomarkers in posterior cortical atrophy
51/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: This prospective observational study included 22 patients with PCA who underwent CSF biomarker analysis of total tau (t-tau), phosphorylated tau on amino acid 181 (p-tau181), and amyloid β (Aβ(42)). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-27
Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease
62/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Changes in functional connectivity in DLB indicate patterns of activation that are distinct from those seen in AD and may improve discrimination of DLB from AD and cognitively normal individuals. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-26
A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
36/100 ✓ Peer-reviewed Risk factors Journal of pineal research
Key finding: Approaches to better understand molecular details behind the rhythmic signalling in the human pineal gland are limited but implicitly warranted, as human chronobiological dysfunctions are often associated with alterations in melatonin synthesis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-26
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
48/100 ✓ Peer-reviewed Risk genes beyond APOE The EMBO journal
Key finding: Previously, we generated APPsα knock-in (KI) mice expressing solely the secreted ectodomain APPsα. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-26
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
52/100 ✓ Peer-reviewed Lewy body dementia PLoS biology
Key finding: Our findings suggest that TDP-43 and FUS, though similar RNA-binding proteins, aggregate and confer disease phenotypes via distinct mechanisms.
Full summary, score breakdown and related studies → Original source
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2011-04-24
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies
51/100 ✓ Peer-reviewed Risk factors Acta neuropathologica
Key finding: In conclusion, it may be most fruitful to focus attention on specific pathways involved in AD rather than attributing it to an inevitable consequence of aging.
Full summary, score breakdown and related studies → Original source
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2011-04-22
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
61/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia
Key finding: The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-21
Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial
74/100 ✓ Peer-reviewed Prevention trials BMC geriatrics
Key finding: SMART will provide a novel evaluation of the immediate and long term benefits of CT, PRT, and combined CT and PRT on global cognitive function and brain morphology, as well as potential underlying mechanisms of adaptation in older adults at risk of further cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-21
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
58/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The new criteria for AD are presented in three documents. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-04-21
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
70/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the link between the pathological cascade of AD and the emergence of clinical symptoms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-21
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
61/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-20
Solanezumab for Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Expert opinion on biological therapy
Key finding: Alzheimer's disease (AD) is a debilitating neurodegenerative illness affecting over 35 million people worldwide.
Full summary, score breakdown and related studies → Original source
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2011-04-20
Population Surveillance of Dementia Mortality
38/100 ✓ Peer-reviewed Risk factors International Journal of Environmental Research and Public Health
Key finding: Use of specific (G30, F01) versus non-specific diagnoses (F02, R54) varied among states and over time, explaining most of the temporal increase in rate of Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-04-19
Intra-individual variability in Alzheimer's disease and cognitive aging: definitions, context, and effect sizes
45/100 ✓ Peer-reviewed Long-term cohort studies PloS one
Key finding: Sample statistics were computed from ADNI cohorts with no cognitive diagnosis, a diagnosis of mild cognitive impairment (MCI), and a diagnosis of possible or probable Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-19
Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis
51/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: Using a targeted proteomic screen, we identified novel candidate biomarkers that complement the best current CSF biomarkers for distinguishing very mildly/mildly demented from cognitively normal individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-18
Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method
40/100 ✓ Peer-reviewed Risk factors International journal of molecular sciences
Key finding: Moreover, the results were compared to the standard Ellman's method.
Full summary, score breakdown and related studies → Original source
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2011-04-17
Effect of interventions to reduce potentially inappropriate use of drugs in nursing homes: a systematic review of randomised controlled trials
67/100 ✓ Peer-reviewed Clinical safety BMC geriatrics
Key finding: Interventions using educational outreach, on-site education given alone or as part of an intervention package and pharmacist medication review may under certain circumstances reduce inappropriate drug use, but the evidence is of low quality. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-04-16
Hypothesis for the pathophysiology of delirium: role of baseline brain network connectivity and changes in inhibitory tone
36/100 ✓ Peer-reviewed Clinical safety Medical hypotheses
Key finding: The pathogenesis of this cognitive disintegration is unclear; herein a hypothesis is proposed that delirium results from an acute breakdown in network connectivity within the brain.
Full summary, score breakdown and related studies → Original source
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2011-04-16
Oxysterols as biomarkers in neurodegenerative diseases
41/100 ✓ Peer-reviewed Genetics Chemistry and physics of lipids
Key finding: In conclusion the analysis of oxysterols in plasma and CSF seems to contribute to investigate the role of cholesterol metabolism in pathogenesis of neurodegeneration and is helpful in the study of patients affected by neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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2011-04-14
Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis
67/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry
Key finding: The APOE-ε4 allele is associated with a moderately increased risk for progression from MCI to AD-type dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-04-14
Cognitive status correlates with white matter alteration in Parkinson's disease
51/100 ✓ Peer-reviewed Mild cognitive impairment Human brain mapping
Key finding: Fractional anisotropy (FA) map of a patient group was compared with that of control subjects by using tract-based spatial statistics. +4 more findings
Full summary, score breakdown and related studies → Original source
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