Newest studies

Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease

46/100 ✓ Peer-reviewed Digital health tools NeuroImage

Key finding: Voxel-based morphometry analysis of SSR scores in SPM5 demonstrated that poorer sarcasm comprehension was predicted by smaller volume in bilateral posterior parahippocampi (PHc), temporal poles, and R medial frontal pole (pFWE<0.05). +1 more finding

Full summary, score breakdown and related studies → Original source

Genome-Wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases

40/100 ✓ Peer-reviewed Genetics American Journal of Epidemiology

Key finding: Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to common complex diseases.

• Genetics

Full summary, score breakdown and related studies → Original source

Hyperglycemia and Glycation in Diabetic Complications

36/100 ✓ Peer-reviewed Brain scans and imaging Antioxidants and Redox Signaling

Key finding: Increasing evidence indicates that hyperglycemia is the initiating cause of the tissue damage occurring in diabetes, either through repeated acute changes in cellular glucose metabolism, or through the long-term accumulation of glycated biomolecules and advanced glycation end products (AGEs).

• Risk Factors

Full summary, score breakdown and related studies → Original source

Episodic simulation of future events is impaired in mild Alzheimer's disease

36/100 ✓ Peer-reviewed Digital health tools Neuropsychologia

Key finding: Recent neuroimaging studies have demonstrated that both remembering the past and simulating the future activate a core neural network including the medial temporal lobes.

Full summary, score breakdown and related studies → Original source

What is 'early onset dementia'?

38/100 ✓ Peer-reviewed Risk genes beyond APOE Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Key finding: Rapid progression of cognitive impairment with neuropsychological syndromes and neurological symptoms has been considered a characteristic of early onset AD. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

36/100 ✓ Peer-reviewed Risk factors Neuron

Key finding: In accord, synaptic glutamate uptake was significantly decreased by soluble Abeta. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The use of the Modified Telephone Interview for Cognitive Status (TICS-M) in the detection of amnestic mild cognitive impairment

47/100 ✓ Peer-reviewed Prevention trials Journal of geriatric psychiatry and neurology

Key finding: There was a significant difference between groups in Modified Telephone Interview for Cognitive Status score (t=8.04, P<.01, noMCI range 32-43, mean [SD]=37.4 [2.5], amnestic mild cognitive impairment range 25-37, mean [SD]=31.2 [3.5]). +1 more finding

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study

66/100 ✓ Peer-reviewed Drug development The Journal of clinical psychiatry

Key finding: The current results do not support the notion that lithium treatment may lead to reduced hyperphosphorylation of tau protein after a short 10-week treatment in the Alzheimer's disease target population. +1 more finding

• Clinical Trials
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants

36/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: A power analysis suggested that the proposed method is suitable for detecting FA and size abnormalities of the white matter in clinical studies.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Fully automatic hippocampus segmentation and classification in Alzheimer's disease and mild cognitive impairment applied on data from ADNI

45/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus

Key finding: The results were previously evaluated by comparison with manual segmentation on data from the 16 young healthy controls, with a leave-one-out strategy, and eight patients with AD.

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Association between late-life social activity and motor decline in older adults

58/100 ✓ Peer-reviewed Brain tissue and pathology Archives of internal medicine

Key finding: Loss of motor function is a common consequence of aging, but little is known about the factors that predict idiopathic motor decline. +3 more findings

• Lifestyle

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Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study

68/100 ✓ Peer-reviewed Cognitive tests and assessment The journal of nutrition, health & aging

Key finding: The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Cognitive impairment in Parkinson's disease: tools for diagnosis and assessment

46/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: Formal neuropsychological examination is required to ascertain the degree and pattern of CI over the course of the disease. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury

43/100 ✓ Peer-reviewed Tau biomarkers Journal of neurosurgery

Key finding: Traumatic brain injury is an important environmental risk factor for the development of Alzheimer disease (AD). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Donepezil delays progression to AD in MCI subjects with depressive symptoms

67/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Cox proportional hazards regression, adjusted for age at baseline, gender, apolipoprotein genotype, and NYU paragraph delayed recall score, showed that higher BDI scores were associated with progression to AD (p = 0.03). +3 more findings

• Early Stage
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Longitudinal pattern of regional brain volume change differentiates normal aging from MCI

70/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Early identification of patterns of abnormality is of fundamental importance for detecting disease onset and tracking progression. +1 more finding

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Hallucinations in Parkinson disease

49/100 ✓ Peer-reviewed Risk factors Nature reviews. Neurology

Key finding: Concomitant or overlapping mechanisms are probably active during VHs, and these include the following: central dopaminergic overactivity and an imbalance with cholinergic neurotransmission; dysfunction of the visual pathways, including specific PD-associated retinopathy and functional alterations of the extrastriate visual pathways; alterations of brainstem sleep-wake and dream regulation; and impaired attentional focus. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

50/100 ✓ Peer-reviewed Getting a diagnosis Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases

Key finding: Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD). +2 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

55/100 ✓ Peer-reviewed Genetics Annals of neurology

Key finding: The brain changes associated with AD may already begin developing early in middle age, especially among APOE epsilon 4 carriers. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Video decision support tool for advance care planning in dementia: randomised controlled trial

79/100 ✓ Peer-reviewed End-of-life care BMJ (Clinical research ed.)

Key finding: Older people who view a video depiction of a patient with advanced dementia after hearing a verbal description of the condition are more likely to opt for comfort as their goal of care compared with those who solely listen to a verbal description. +2 more findings

• Clinical Trials
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease

48/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: Converters had significantly greater metabolic decrease than non-converters in two ventro-medial prefrontal areas, the subgenual (BA25) and anterior cingulate (BA24/32). +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset

36/100 ✓ Peer-reviewed Digital health tools NeuroImage

Key finding: Structural and functional brain images are playing an important role in helping us understand the changes associated with neurological disorders such as Alzheimer's disease (AD). +2 more findings

Full summary, score breakdown and related studies → Original source

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

50/100 ✓ Peer-reviewed Brain scans and imaging International psychogeriatrics

Key finding: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD.

• Brain Scans
• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Markers of cerebral damage during delirium in elderly patients with hip fracture

40/100 ✓ Peer-reviewed Clinical safety BMC neurology

Key finding: Delirium was associated with increased level of S100B which could indicate cerebral damage either due to delirium or leading to delirium. +4 more findings

• Risk Factors

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Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk

55/100 ✓ Peer-reviewed Long-term cohort studies The American journal of clinical nutrition

Key finding: Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up. +3 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source