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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,201–20,225 of 27,380 studies, newest first · page 809 of 1096.

April 2011 2

  1. 2011-04-01

    A phase II trial of huperzine A in mild to moderate Alzheimer disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: The primary efficacy analysis did not show cognitive benefit with huperzine A 200 μg BID. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2011-04-01

    Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers

    ✓ Peer-reviewed Genetics Neurology

    Key finding: No frontal cognitive effects were as robust as memory decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

March 2011 23

  1. 2011-03-31

    Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

    ✓ Peer-reviewed Disease mechanisms Human molecular genetics

    Key finding: We found increased expression of the mitochondrial fission genes Drp1 and Fis1 (fission 1) and decreased expression of the mitochondrial fusion genes Mfn1 (mitofusin 1), Mfn2 (mitofusin 2), Opa1 (optic atrophy 1) and Tomm40. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2011-03-31

    Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Clinical neurology and neurosurgery

    Key finding: Our data confirm the retinal involvement in AD, as reflected by loss of axons in the optic nerves. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2011-03-31

    Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment

    ✓ Peer-reviewed Inflammation and the immune system Stroke

    Key finding: Our results support the hypothesis that MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of SIVD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2011-03-30

    Linking lipids to Alzheimer's disease: cholesterol and beyond

    ✓ Peer-reviewed Drug development Nature reviews. Neuroscience

    Key finding: Although much attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic acid, have an important role.

    Full summary, score breakdown and related studies → Original source

  5. 2011-03-30

    NADPH-oxidase activation and cognition in Alzheimer disease progression

    ✓ Peer-reviewed Mild cognitive impairment Free radical biology & medicine

    Key finding: Biochemical methods were used to determine overall NOX activity as well as levels of the various subunits (gp91(phox), p67(phox), p47(phox), p40(phox), and p22(phox)). +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2011-03-28

    Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

    Key finding: Although originally discounted as a secondary process occurring as a result of neurodegeneration, more recent data suggest that alterations in excitatory-inhibitory (E/I) balance occur in AD and may be a primary mechanism contributing AD cognitive decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2011-03-25

    Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed Costs and economics Journal of neuroinflammation

    Key finding: At present, the few agents that are FDA-approved for the treatment of AD have demonstrated only modest effects in modifying clinical symptoms for relatively short periods and none has shown a clear effect on disease progression. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2011-03-25

    Parallel findings in age-related macular degeneration and Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Progress in retinal and eye research

    Key finding: We have focused on the role of Aβ as a key regulator of the progression from drusen to AMD, and our results have shown that Aβ causes an imbalance of angiogenesis-related factors in the retinal pigment epithelial (RPE) cells. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2011-03-25

    Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: It is recommended that the IOH definition be applied when taking continuous noninvasive orthostatic BP measurements in older people. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2011-03-25

    A peculiar constellation of tau pathology defines a subset of dementia in the elderly

    ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

    Key finding: Argyrophilic grains were detected in four patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2011-03-24

    Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

    ✓ Peer-reviewed Disease mechanisms Molecular bioSystems

    Key finding: However, unexpectedly, recent clinicopathological studies have shown no evidence that the pathological hallmarks of AD, including amyloid plaque, were increased in the brains of diabetic patients, suggesting that DM could affect the pathogenesis of AD through mechanisms other than modulation of Aβ metabolism. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2011-03-23

    Advances in metal-induced oxidative stress and human disease

    ✓ Peer-reviewed Risk factors Toxicology

    Key finding: Detailed studies in the past two decades have shown that redox active metals like iron (Fe), copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions and possess the ability to produce reactive radicals such as superoxide anion radical and nitric oxide in biological systems.

    Full summary, score breakdown and related studies → Original source

  13. 2011-03-23

    Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study

    ✓ Peer-reviewed Mild cognitive impairment NeuroImage

    Key finding: We combined the power of parametric surface modeling and tensor-based morphometry to study hippocampal differences associated with AD and mild cognitive impairment (MCI) in 490 subjects (97 AD, 245 MCI, 148 controls) and ventricular differences in 804 subjects scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI; 184 AD, 391 MCI, 229 controls).

    Full summary, score breakdown and related studies → Original source

  14. 2011-03-22

    Total numbers of neurons and glial cells in cortex and basal ganglia of aged brains with Down syndrome--a stereological study

    ✓ Peer-reviewed Down syndrome and Alzheimer's Cerebral cortex (New York, N.Y. : 1991)

    Key finding: We conclude that trisomy 21 affects cortical structures more than central gray matter emphasizing the differential impairment of brain development.

    Full summary, score breakdown and related studies → Original source

  15. 2011-03-21

    A family booklet about comfort care in advanced dementia: three-country evaluation

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: The booklet is suitable to inform Dutch and Canadian families on comfort care in dementia, but implementation in Italy requires further consideration. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2011-03-21

    Risk factors for aspiration pneumonia in frail older people: a systematic literature review

    ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association

    Key finding: Thirteen significant risk factors were identified: age, male gender, lung diseases, dysphagia, diabetes mellitus, severe dementia, angiotensin I-converting enzyme deletion/deletion genotype, bad oral health, malnutrition, Parkinson's disease, and the use of antipsychotic drugs, proton pump inhibitors, and angiotensin-converting enzyme inhibitors. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2011-03-21

    Comparison of 7.0-T T₂*-magnetic resonance imaging of cerebral bleeds in post-mortem brain sections of Alzheimer patients with their neuropathological correlates

    ✓ Peer-reviewed Brain scans and imaging Cerebrovascular diseases (Basel, Switzerland)

    Key finding: When evaluating the 'bleeding load' with 7.0-T T₂*-weighted MRI in post-mortem brain sections of patients with dementia and vascular risk factors, only quantification of small cerebral bleeds in the cortico-subcortical regions is reliable. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2011-03-21

    For debate: substituting placebo controls in long-term Alzheimer's prevention trials

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: Forecasted outcomes are compared with outcomes observed on candidate drugs, thus replacing a concomitant placebo group. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2011-03-20

    Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

    ✓ Peer-reviewed Inflammation and the immune system Nature biotechnology

    Key finding: The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.

    Full summary, score breakdown and related studies → Original source

  20. 2011-03-18

    Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Here we report that the intracellular trafficking of apoE4 is impaired in Neuro-2a cells and primary neurons, as shown by measuring fluorescence recovery after photobleaching. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2011-03-18

    Incidence of dementia and cognitive impairment, not dementia in the United States

    ✓ Peer-reviewed Mild cognitive impairment Annals of neurology

    Key finding: The incidence of CIND is greater than the incidence of dementia, and those with CIND are at high risk of progressing to dementia, making CIND a potentially valuable target for treatments aimed at slowing cognitive decline.

    Full summary, score breakdown and related studies → Original source

  22. 2011-03-17

    Amyloid-β associated cortical thinning in clinically normal elderly

    ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology

    Key finding: We conclude that Aβ deposition is associated with a pattern of cortical thickness reduction consistent with AD prior to the development of cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2011-03-16

    Interventions for improving palliative care for older people living in nursing care homes

    ✓ Peer-reviewed End-of-life care The Cochrane database of systematic reviews

    Key finding: Main results Two RCTs and one controlled before-and-after study were included (735 participants). +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →