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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 20,426–20,450 of 27,380 studies, newest first · page 818 of 1096.

December 2010 19

  1. 2010-12-01

    Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Recent research on Alzheimer's disease (AD) has shown that the decline of cognitive and memory functions is accompanied by a disrupted neuronal connectivity characterized by white matter (WM) degeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2010-12-01

    APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42

    ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: APOE4 allele carriers (E4+) differed significantly from E4- in functional connectivity of the precuneus to several regions previously defined as having abnormal connectivity in a group of AD participants. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2010-12-01

    Hospice care for persons with dementia: The growth of access in US nursing homes

    ✓ Peer-reviewed End-of-life care American journal of Alzheimer's disease and other dementias

    Key finding: Over 40% of US NH decedents have mild-to-moderately severe or advanced dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2010-12-01

    Use it or lose it? Wii brain exercise practice and reading for domain knowledge

    ✓ Peer-reviewed Prevention trials Psychology and aging

    Key finding: We investigated the training effects and transfer effects associated with 2 approaches to cognitive activities (so-called brain training) that might mitigate age-related cognitive decline. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2010-12-01

    Neuroprotective strategies involving ROS in Alzheimer disease

    ✓ Peer-reviewed Inflammation and the immune system Free radical biology & medicine

    Key finding: It occurs early in disease pathogenesis and can exacerbate its progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2010-12-01

    Immunohistochemical characterization of microglia in Nasu-Hakola disease brains

    ✓ Peer-reviewed TREM2 and immune genetics Neuropathology : official journal of the Japanese Society of Neuropathology

    Key finding: TREM2 and DAP12 constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells (DC), macrophages and microglia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2010-12-01

    Genetics of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Journal of geriatric psychiatry and neurology

    Key finding: Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2010-12-01

    Tau in Alzheimer disease and related tauopathies

    ✓ Peer-reviewed Lewy body dementia Current Alzheimer research

    Key finding: The cytosolic abnormally hyperphosphorylated tau, because of oligomerization, unlike normal tau, is sedimentable and on self-assembly into PHF/SF, loses its ability to sequester normal MAPs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2010-12-01

    Frontotemporal dementia: a review for primary care physicians

    ✓ Peer-reviewed Digital health tools American family physician

    Key finding: Common language features are loss of comprehension and object knowledge (semantic dementia), and nonfluent and hesitant speech (progressive nonfluent aphasia). +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2010-12-01

    Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study

    ✓ Peer-reviewed Digital health tools Neurology

    Key finding: Having multiple CMBs or concomitant CMBs and retinopathy is associated with a profile of vascular cognitive impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2010-12-01

    Exome sequencing reveals VCP mutations as a cause of familial ALS

    ✓ Peer-reviewed How common it is Neuron

    Key finding: Our data broaden the phenotype of IBMPFD to include motor neuron degeneration, suggest that VCP mutations may account for ∼1%-2% of familial ALS, and provide evidence directly implicating defects in the ubiquitination/protein degradation pathway in motor neuron degeneration.

    Full summary, score breakdown and related studies → Original source

  12. 2010-12-01

    Hospice use and outcomes in nursing home residents with advanced dementia

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: A minority of NH residents with advanced dementia received hospice care. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2010-12-01

    The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke

    ✓ Peer-reviewed Getting a diagnosis Journal of the neurological sciences

    Key finding: The MoCA is more sensitive than the MMSE in screening for cognitive impairment after acute stroke. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2010-12-01

    HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities.

    Full summary, score breakdown and related studies → Original source

  15. 2010-12-01

    Vascular basis for brain degeneration: faltering controls and risk factors for dementia

    ✓ Peer-reviewed Prevention and risk Nutrition reviews

    Key finding: The strongest risk factor for brain degeneration, whether it results from vascular or neurodegenerative mechanisms or both, is age.

    Full summary, score breakdown and related studies → Original source

  16. 2010-12-01

    A memory and organizational aid improves Alzheimer disease research consent capacity: results of a randomized, controlled trial

    ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: A consent process that addresses the deficits in memory and attention of a patient with AD can improve capacity to give informed consent for early phase AD research. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2010-12-01

    Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42

    ✓ Peer-reviewed Genetics Annals of neurology

    Key finding: Forty of 105 (38%) were classified as NC-low, and 65 (62%) as NC-high. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2010-12-01

    Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort

    ✓ Peer-reviewed Genetics Neurology

    Key finding: In addition to known candidate genes, APOE, TOMM40, and one hypothetical gene LOC100129500 partially overlapping APOE; one novel gene, EPC2, and several other interesting genes were associated with CSF biomarkers that are related to AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2010-12-01

    Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease

    ✓ Peer-reviewed Genetics Archives of neurology

    Key finding: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

November 2010 6

  1. 2010-11-30

    Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: Because AD is associated with mitochondrial dysfunction, we examined the effect of apoE4 domain interaction on mitochondrial respiratory function. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2010-11-29

    Activation and intrinsic gamma-secretase activity of presenilin 1

    ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Importantly, we demonstrate that rPS harboring mutations that cause early onset familial Alzheimer's disease (FAD) lead to elevations in the ratio of Aβ42 to Aβ40 peptides produced from a wild-type APP substrate and that rPS enhances the Aβ42/Aβ40 peptide ratio from FAD-linked mutant APP substrates, findings that are entirely consistent with the results obtained in in vivo settings.

    Full summary, score breakdown and related studies → Original source

  3. 2010-11-28

    Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: Here we show that amyloid-β oligomers bind to the fibronectin repeats domain of EphB2 and trigger EphB2 degradation in the proteasome. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2010-11-26

    Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice

    ✓ Peer-reviewed Biomarkers Brain research

    Key finding: Isolation had several effects on the APP/PS1 transgenic mice, including exacerbating the impairment of spatial working memory associated with increased Aβ42/Aβ40 ratio in the hippocampus; increased levels of MnSOD in the CA1-CA3 subregions of the hippocampus, basolateral part of the amygdala (BLA), and locus coeruleus (LC); and decreased numbers of cholinergic cells in the diagonal band of Broca (DB), noradrenergic neurons in LC, serotonergic neurons in the Raphe nucleus, and levels of NMDA 2B receptor (NR2B) in the hippocampus region. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2010-11-22

    Neurobehavioral effects of long-term exposure to pesticides: results from the 4-year follow-up of the PHYTONER Study

    ✓ Peer-reviewed Risk factors Occupational and Environmental Medicine

    Key finding: 614 subjects were available for investigation at follow-up. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2010-11-22

    Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Affinity chromatography and immunoprecipitation experiments together with PP2A activity assays indicate that metformin interferes with the association of the catalytic subunit of PP2A (PP2Ac) to the so-called MID1-α4 protein complex, which regulates the degradation of PP2Ac and thereby influences PP2A activity.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →