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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,526–19,550 of 27,380 studies, newest first · page 782 of 1096.

April 2012 25

  1. 2012-04-15

    Identification of common variants associated with human hippocampal and intracranial volumes

    ✓ Peer-reviewed Hippocampus size on brain scans Nature genetics

    Key finding: The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2012-04-14

    Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation

    ✓ Peer-reviewed Biomarkers The American journal of pathology

    Key finding: Interestingly, the AD-associated PS1(L166P) variant revealed a partial loss of γ-secretase function, resulting in the decreased production of endogenous Aβ40 and an increased Aβ42/40 ratio.

    Full summary, score breakdown and related studies → Original source

  3. 2012-04-13

    Supplementation with DHA and the psychological functioning of young adults

    ✓ Peer-reviewed Clinical trials The British journal of nutrition

    Key finding: No significant differences in mood, reaction times, vigilance or visual acuity were found.

    Full summary, score breakdown and related studies → Original source

  4. 2012-04-13

    Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

    Key finding: Here we report a frequency of 11.2% of mutations and variants in the known Alzheimer disease genes in the dementia cohort studied and 24% in the early onset subgroup of patients, suggesting that mutations in these genes are not uncommon in Turkey and are associated with various phenotypes.

    Full summary, score breakdown and related studies → Original source

  5. 2012-04-13

    The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE The EMBO journal

    Key finding: FAD mutations increase the release of amyloid β (Aβ)42 relative to Aβ40 by an unknown, possibly gain-of-toxic-function, mechanism. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2012-04-13

    Validity of the Italian version of the Pittsburgh Sleep Quality Index (PSQI)

    ✓ Peer-reviewed Risk factors Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: The PSQI showed an overall reliability coefficient (Cronbach's α) of 0.835, indicating a high degree of internal consistency. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2012-04-12

    Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1

    ✓ Peer-reviewed Disease mechanisms The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: The emerging data indicate that synaptic function decreases with age and that IGF-1 contributes to information processing in the brain. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2012-04-12

    The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-the-art overview and future directions

    ✓ Peer-reviewed Brain tissue and pathology Schizophrenia bulletin

    Key finding: We look at some of the most prominent descriptive features of AVHs in schizophrenia (SZ). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2012-04-12

    Prevalence and correlates for sleep complaints in older adults in low and middle income countries: a 10/66 Dementia Research Group study

    ✓ Peer-reviewed Disparities Sleep medicine

    Key finding: This study robustly characterized the prevalence of sleep complaints in large samples of the elderly in LAMICs and identified potential risk factors that may be specific to these populations. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2012-04-12

    Effectiveness of a condensed protocol for disclosing APOE genotype and providing risk education for Alzheimer disease

    ✓ Peer-reviewed Treatments Genetics in medicine : official journal of the American College of Medical Genetics

    Key finding: A condensed protocol for communicating genetic risk for Alzheimer disease achieved similar educational results as an extended protocol in this study. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2012-04-11

    NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Trends in pharmacological sciences

    Key finding: The failure of free-radical-scavenging antioxidants in clinical trials pinpoints an urgent need to identify and to block major sources of oxidative stress in neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2012-04-11

    Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

    ✓ Peer-reviewed Genetics Molecular neurodegeneration

    Key finding: These results suggest that GSTO locus variants may lower brain GSTO2 levels and consequently confer AD risk in older age. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2012-04-10

    Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

    ✓ Peer-reviewed Disease mechanisms Neuroscience letters

    Key finding: Dantrolene treatment for 11 months significantly reduced both memory deficits and amyloid plaque load in the hippocampus in 13-month-old 3xTg-AD mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2012-04-09

    The ketogenic diet as a treatment paradigm for diverse neurological disorders

    ✓ Peer-reviewed Risk factors Frontiers in pharmacology

    Key finding: Further, it is possible that a final common neurometabolic pathway might be influenced by a variety of dietary interventions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2012-04-09

    An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: This cross-sectional evaluation of the NIA-AA criteria for preclinical AD indicates that the 1-3 staging criteria coupled with stage 0 and SNAP categories classify 97% of CN subjects from a population-based sample, leaving only 3% unclassified. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2012-04-06

    Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    ✓ Peer-reviewed Brain tissue and pathology Journal of Neuropathology & Experimental Neurology

    Key finding: Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2012-04-05

    Health implications of high dietary omega-6 polyunsaturated Fatty acids

    ✓ Peer-reviewed Risk factors Journal of nutrition and metabolism

    Key finding: Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA.

    Full summary, score breakdown and related studies → Original source

  18. 2012-04-05

    A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders

    ✓ Peer-reviewed Prevention trials The British journal of nutrition

    Key finding: The benefits of fruit products are thought to be a result of its polyphenol content.

    Full summary, score breakdown and related studies → Original source

  19. 2012-04-03

    High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Molecular psychiatry

    Key finding: These mutations were not retrieved in 1500 controls of same ethnic origin. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2012-04-01

    A review: inflammatory process in Alzheimer's disease, role of cytokines

    ✓ Peer-reviewed Brain tissue and pathology TheScientificWorldJournal

    Key finding: By contrast, other cytokines such as IL-1 receptor antagonist (IL-1ra), IL-4, IL-10, and transforming growth factor (TGF)-β can suppress both proinflammatory cytokine production and their action, subsequently protecting the brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2012-04-01

    Bilingualism: consequences for mind and brain

    ✓ Peer-reviewed Risk factors Trends in cognitive sciences

    Key finding: We discuss recent evidence that bilingualism is associated with a delay in the onset of symptoms of dementia.

    Full summary, score breakdown and related studies → Original source

  22. 2012-04-01

    New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

    ✓ Peer-reviewed Treatments British journal of clinical pharmacology

    Key finding: Unfortunately none of these drugs has demonstrated efficacy in phase 3 studies.

    Full summary, score breakdown and related studies → Original source

  23. 2012-04-01

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    ✓ Peer-reviewed Drug development The Journal of clinical investigation

    Key finding: We found that amyloid-β peptide (Aβ) oligomers, synaptotoxins that accumulate in the brains of AD patients, activated the JNK/TNF-α pathway, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr in mature cultured hippocampal neurons. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2012-04-01

    Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

    ✓ Peer-reviewed Genetics The Journal of clinical investigation

    Key finding: While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2012-04-01

    Abnormalities in hippocampal functioning with persistent pain

    ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: We found that SNI animals were unable to extinguish contextual fear and showed increased anxiety-like behavior. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →