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Cognitive status correlates with white matter alteration in Parkinson's disease
Hattori T, Orimo S, Aoki S, Ito K, Abe O, Amano A, Sato R, Sakai K et al.. Human brain mapping, 2011-04-14
Topic: Risk, prevention and care in population studies
Patients with Parkinson's disease (PD) can develop mild cognitive impairment (PD-MCI), frequently progressing to dementia (PDD). Here, we aimed to elucidate the relationship between white matter alteration and cognitive status in PD and dementia with Lewy bodies (DLB) by using diffusion tensor imaging. We also compared the progression patterns of white and gray matter and the cerebral perfusion. We enrolled patients with PD cognitively normal (PD-CogNL, n = 32), PD-MCI (n = 28), PDD (n = 25), DLB (n = 29), and age- and sex-matched healthy control subjects (n = 40). Fractional anisotropy (FA) map of a patient group was compared with that of control subjects by using tract-based spatial statistics. For the patient cohort, intersubject voxel-wise correlation was performed between FA values and Mini-Mental Status Examination (MMSE) scores. We also evaluated the gray matter and the cerebral perfusion by conducting a voxel-based analysis. There were significantly decreased FA values in many major tracts in patients with PD-MCI, PDD, and DLB, but not in PD-CogNL, compared with control subjects. FA values in the certain white matter areas, particularly the bilateral parietal white matter, were significantly correlated with MMSE scores in patients with PD. Patients with PDD and DLB had diffuse gray matter atrophy. All patient groups had occipital and posterior parietal hypoperfusion when compared with control subjects. Our results suggest that white matter damage underlies cognitive impairment in PD, and cognitive impairment in PD progresses with functional alteration (hypoperfusion) followed by structural alterations in which white matter alteration precedes gray matter atrophy.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hattori, T., Orimo, S., Aoki, S., Ito, K., Abe, O., Amano, A., et al. (2012). Cognitive status correlates with white matter alteration in Parkinson's disease. Human brain mapping. https://doi.org/10.1002/hbm.21245
Vancouver
Hattori T, Orimo S, Aoki S, Ito K, Abe O, Amano A, et al. Cognitive status correlates with white matter alteration in Parkinson's disease. Human brain mapping. 2012. doi:10.1002/hbm.21245. PMID: 21495116.
BibTeX
@article{hattori2012-21495116,
author = {Hattori, T. and Orimo, S. and Aoki, S. and Ito, K. and Abe, O. and Amano, A. and Sato, R. and Sakai, K. and others},
title = {{Cognitive status correlates with white matter alteration in Parkinson's disease}},
journal = {Human brain mapping},
year = {2012},
doi = {10.1002/hbm.21245},
pmid = {21495116},
url = {https://doi.org/10.1002/hbm.21245}
}
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Key findings
- Fractional anisotropy (FA) map of a patient group was compared with that of control subjects by using tract-based spatial statistics.
- There were significantly decreased FA values in many major tracts in patients with PD-MCI, PDD, and DLB, but not in PD-CogNL, compared with control subjects.
- FA values in the certain white matter areas, particularly the bilateral parietal white matter, were significantly correlated with MMSE scores in patients with PD.
- All patient groups had occipital and posterior parietal hypoperfusion when compared with control subjects.
- Our results suggest that white matter damage underlies cognitive impairment in PD, and cognitive impairment in PD progresses with functional alteration (hypoperfusion) followed by structural alterations in which white matter alteration precedes gray matter atrophy.
Why it matters
This study found reduced fractional anisotropy in major white matter tracts in people with Parkinson's disease and mild cognitive impairment, Parkinson's disease dementia, and dementia with Lewy bodies, and these values correlated with cognitive test scores. It concerns Parkinson's disease and related dementias rather than Alzheimer's disease, and it does not test any treatment.
Study details
- Participants32
- Evidence strengthModerate
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Human brain mapping) |
| Journal's citation record | 3 / 4 | Human Brain Mapping: journal h-index 271 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2012 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 32 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 202 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.6 citations a year over 16 year(s) since 2012 |
| Impact for its field and year | 3 / 6 | Cited 7.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Hidehiro Mizusawa: h-index 71 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Tokyo: institution h-index 1,463 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21495116) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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