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CSF biomarkers in posterior cortical atrophy
Seguin J, Formaglio M, Perret-Liaudet A, Quadrio I, Tholance Y, Rouaud O, Thomas-Anterion C, Croisile B et al.. Neurology, 2011-04-27
Topic: Brain proteins, microglia and lab models
Objective To describe CSF biomarker profiles in posterior cortical atrophy (PCA), which induces high-order visual deficits often associated with Alzheimer disease (AD) pathology, and relate these findings to clinical and neuropsychological assessment. Methods This prospective observational study included 22 patients with PCA who underwent CSF biomarker analysis of total tau (t-tau), phosphorylated tau on amino acid 181 (p-tau181), and amyloid β (Aβ(42)). At group level, the CSF profiles of patients with PCA were compared to those of patients with typical AD and patients with other dementia (OD).
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APA 7th
Seguin, J., Formaglio, M., Perret-Liaudet, A., Quadrio, I., Tholance, Y., Rouaud, O., et al. (2011). CSF biomarkers in posterior cortical atrophy. Neurology. https://doi.org/10.1212/wnl.0b013e31821ccc98
Vancouver
Seguin J, Formaglio M, Perret-Liaudet A, Quadrio I, Tholance Y, Rouaud O, et al. CSF biomarkers in posterior cortical atrophy. Neurology. 2011. doi:10.1212/wnl.0b013e31821ccc98. PMID: 21525425.
BibTeX
@article{seguin2011-21525425,
author = {Seguin, J. and Formaglio, M. and Perret-Liaudet, A. and Quadrio, I. and Tholance, Y. and Rouaud, O. and Thomas-Anterion, C. and Croisile, B. and others},
title = {{CSF biomarkers in posterior cortical atrophy}},
journal = {Neurology},
year = {2011},
doi = {10.1212/wnl.0b013e31821ccc98},
pmid = {21525425},
url = {https://doi.org/10.1212/wnl.0b013e31821ccc98}
}
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Key findings
- Methods This prospective observational study included 22 patients with PCA who underwent CSF biomarker analysis of total tau (t-tau), phosphorylated tau on amino acid 181 (p-tau181), and amyloid β (Aβ(42)).
- At group level, the CSF profiles of patients with PCA were compared to those of patients with typical AD and patients with other dementia (OD).
- Individually, the clinical presentation of patients with PCA was correlated to their CSF profile to assess the predictability of clinical features for diagnosis of underlying AD pathology.
- Results At group level, the PCA biomarker profile was not different from that of the AD group, but very different from that of the OD group (p Conclusions PCA syndrome is usually associated with CSF biomarkers suggestive of AD, as shown by previous neuropathologic studies.
Why it matters
This study described cerebrospinal fluid biomarker profiles in 22 patients with posterior cortical atrophy and compared them to patients with typical Alzheimer's disease and other dementias. It is a small observational study and does not test any treatment, cure, or prevention.
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Study details
- Participants22
- Evidence strengthLow
How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 22 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 86 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.1 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 3 / 6 | Cited 7.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Pierre Krolak‐Salmon: h-index 50 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21525425) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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