Oxysterols as biomarkers in neurodegenerative diseases
Leoni V, Caccia C.. Chemistry and physics of lipids, 2011-04-16
Topic: Brain proteins, microglia and lab models
In conclusion the analysis of oxysterols in plasma and CSF seems to contribute to investigate the role of cholesterol metabolism in pathogenesis of neurodegeneration and is helpful in the study of patients affected by neurodegenerative diseases.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Leoni, V., & Caccia, C. (2011). Oxysterols as biomarkers in neurodegenerative diseases. Chemistry and physics of lipids. https://doi.org/10.1016/j.chemphyslip.2011.04.002
Vancouver
Leoni V, Caccia C. Oxysterols as biomarkers in neurodegenerative diseases. Chemistry and physics of lipids. 2011. doi:10.1016/j.chemphyslip.2011.04.002. PMID: 21515244.
BibTeX
@article{leoni2011-21515244,
author = {Leoni, V. and Caccia, C.},
title = {{Oxysterols as biomarkers in neurodegenerative diseases}},
journal = {Chemistry and physics of lipids},
year = {2011},
doi = {10.1016/j.chemphyslip.2011.04.002},
pmid = {21515244},
url = {https://doi.org/10.1016/j.chemphyslip.2011.04.002}
}
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Key findings
- In conclusion the analysis of oxysterols in plasma and CSF seems to contribute to investigate the role of cholesterol metabolism in pathogenesis of neurodegeneration and is helpful in the study of patients affected by neurodegenerative diseases.
Why it matters
This paper concludes that measuring oxysterols in plasma and cerebrospinal fluid may help investigate the role of cholesterol metabolism in neurodegeneration and may be helpful in studying patients with neurodegenerative diseases. It concerns a possible biomarker, not a treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Chemistry and physics of lipids) |
| Journal's citation record | 2 / 4 | Chemistry and Physics of Lipids: journal h-index 158 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 213 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.5 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 5 / 6 | Cited 21.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 23 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Claudio Caccia: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Fondazione IRCCS Istituto Neurologico Carlo Besta: institution h-index 417 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21515244) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
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