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Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes
Joel Eyamu, Boncho Uk Ku, Kahye Kim, Kun Ho Lee, Jaeuk U. Kim. Frontiers in Aging Neuroscience, 2026-01-08
Topic: Brain proteins, microglia and lab models
Results We found interactions between APOE4 and cognitive states in the aperiodic EEG exponent and the spectral power ratio (SPR). Furthermore, the CN had a lower SPR compared to the naMCI.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Eyamu, J., Ku, B. U., Kim, K., Lee, K. H., & Kim, J. U. (2026). Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2025.1675330
Vancouver
Eyamu J, Ku BU, Kim K, Lee KH, Kim JU. Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes. Frontiers in Aging Neuroscience. 2026. doi:10.3389/fnagi.2025.1675330. PMID: 41583006.
BibTeX
@article{eyamu2026-41583006,
author = {Eyamu, Joel and Ku, Boncho Uk and Kim, Kahye and Lee, Kun Ho and Kim, Jaeuk U.},
title = {{Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes}},
journal = {Frontiers in Aging Neuroscience},
year = {2026},
doi = {10.3389/fnagi.2025.1675330},
pmid = {41583006},
url = {https://doi.org/10.3389/fnagi.2025.1675330}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results We found interactions between APOE4 and cognitive states in the aperiodic EEG exponent and the spectral power ratio (SPR).
- Furthermore, the CN had a lower SPR compared to the naMCI.
Why it matters
This study found interactions between APOE ε4 and cognitive states in aperiodic electroencephalogram measures, and a lower spectral power ratio in cognitively normal participants compared to those with non-amnestic mild cognitive impairment. It describes associations and does not test any treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Aging Neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 9.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jaeuk U. Kim: h-index 23 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Korea University of Science and Technology: institution h-index 336 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41583006) |
| Free to read | 2 / 2 | Free to read |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnagi.2025.1675330
- PubMed: 41583006
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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