Newest studies

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: Residence in the most disadvantaged neighborhoods may be associated with lower amyloid pathology in cognitively impaired individuals. +3 more findings

• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults

67/100 ✓ Peer-reviewed Vascular contributions JAMA Network Open

Key finding: Among 11 601 participants (mean [SD] age, 59.18 [9.41] years; 5569 male [48.0%]), 9145 (78.8%) were exposed to at least 1 ACE indicator, 4241 (36.6%) to at least 1 AAE indicator, and 3531 (30.4%) to both ACE and AAE markers. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Additional hospitalization costs associated with delirium among older adults: evidence from the Medicare Current Beneficiary Survey

47/100 ✓ Peer-reviewed Clinical safety Frontiers in Public Health

Key finding: In a sample of 2,599 Medicare beneficiaries (mean age 78.4 years, 52.9% female, 81.8% White), we identified a total of 5,677 hospitalization claims. +4 more findings

• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

55/100 ✓ Peer-reviewed Disease mechanisms Cell

Key finding: These results systematically reveal principles of tau proteostasis in human neurons and suggest potential therapeutic targets for tauopathies.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Chronic Exposure to Thermally Processed Food-Derived Carbon Polymers Accelerated Neuroinflammation in Alzheimer Disease Mice through Microbe–Gut–Brain Axis

37/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Agricultural and Food Chemistry

Key finding: Processed foods are increasingly associated with the prevalence of neurodegenerative diseases, including Alzheimer disease (AD). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Towards the development of a management protocol for subjective cognitive decline: Insights from a cross-sectional and longitudinal analysis of multimodal data from a memory clinic

44/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: This study highlights the role of age, gender, APOE genotype, and depressive symptoms in the presentation and progression of cognitive decline. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Caregiver burden and quality of life associated with behavioral and psychological symptoms of Alzheimer's disease: A web-based cross-sectional survey study

44/100 ✓ Peer-reviewed Caregiving Journal of Alzheimer s Disease

Key finding: A significant association between increased caregiver burden and BPSD in patients with AD was demonstrated, which may be associated with decreased caregiver healthcare and social care-related QOL. +1 more finding

• Caregiving

Full summary, score breakdown and related studies → Original source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

43/100 ✓ Peer-reviewed Brain scans and imaging Annals of Clinical and Translational Neurology

Key finding: These findings support the feasibility, tolerability, and high patient acceptability of pMRI. +2 more findings

• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages

52/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: This study investigated whether longitudinal changes in CSF AD biomarkers were associated with 18 F-MK6240 tau PET measures in early Braak stage subregions. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories

63/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: This study highlights challenges for the reproducibility of α-syn SAA results across different protocols applied by different laboratories. +4 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons

38/100 ✓ Peer-reviewed Disease mechanisms Molecular Neurodegeneration Advances

Key finding: Current findings suggest that tau accumulation and glial-driven neuroinflammation creates an environment that promotes the activation and recruitment of effector T cells into the tauopathy brain.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease

41/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Immunology

Key finding: Hippocampal pan-histone H3 crotonylation (H3Kcr) and H3K18cr were significantly upregulated in both 5xFAD and Aβ42-injected mice compared to controls. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Artificial intelligence in atrial fibrillation – Timely diagnosis, risk assessment and personalized management

38/100 ✓ Peer-reviewed Digital health tools Indian Pacing and Electrophysiology Journal

Key finding: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide and is associated with substantial morbidity and mortality, including stroke, systemic embolism, heart failure, and dementia.

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Alzheimer’s disease and related dementias in rural medicare populations: a scoping review

47/100 ✓ Peer-reviewed Disparities BMC Geriatrics

Key finding: Thirty-three studies were included, most published after 2019 (72.7%). +4 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort

55/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: A total of 503 participants (mean [SD] age, 64.6 [2.8] years; 321 [63.8%] women; 305 [60.6%] Hispanic, 120 [23.9%] non-Hispanic Black, and 78 [15.5%] non-Hispanic White) with Aβ PET, MRI (n = 501), and tau PET (n = 355) data were studied. +4 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Integrated bio-cooperative robotic platform for virtual cognitive training in Parkinson's disease: design and methodology of the OPERA project

42/100 ✓ Peer-reviewed Prevention trials Frontiers in Neurology

Key finding: Mild cognitive impairment in Parkinson's disease (PD-MCI) can affect several cognitive domains, including attention, working memory, executive functions, language, visuospatial skills, and episodic memory, resulting in a progressive reduction of autonomy and an increased risk of dementia.

• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Assessing the Roles of Aging, Estrogen, Nutrition, and Neuroinflammation in Women and Their Involvement in Alzheimer’s Disease—A Narrative Overview

41/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: Thus, this overview covers the following four pillars (1) a brief background on cognitive decline and AD with aging, (2) the importance of and changes in estrogen with aging, (3) influence of dietary choices on overall well-being and brain health, and (4) the biochemical and molecular mechanisms by which this combination of factors may lead to neuroinflammation, resulting in cognitive decline and AD. +1 more finding

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy

57/100 ✓ Peer-reviewed Risk genes beyond APOE JAMA Neurology

Key finding: Of 70 autopsied individuals (62 male, 8 female; mean [SD] age, 64.40 [13.94] years), 20 showed CTE-NC in the brain. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study

43/100 ✓ Peer-reviewed Tau biomarkers Annals of human genetics

Key finding: The causes of LOAD are not known but several recent lines of evidence implicate the adaptive immune system. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

A retrieval-augmented generation large language model framework for accurate dementia identification from electronic health records

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: A RAG-based LLM pipeline without structured ICD codes improved dementia ascertainment from EHR data compared with ICD-based rules and keyword-based filtering. +3 more findings

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Real-World Characterization of Amyloid-Related Imaging Abnormalities (ARIA) in Lecanemab Treatment at an Academic Health System

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: The overall incidence of any ARIA was 25.2%, with ARIA-H occurring in 22.4% of patients and ARIA-E in 12.2%. +2 more findings

• Treatments
• Side Effects
• Brain Scans

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns

47/100 ✓ Peer-reviewed Prevention trials EXCLI journal

Key finding: Accumulating evidence indicates that dementia is not an inevitable consequence of aging and that up to 45 % of cases may be attributable to potentially modifiable lifestyle and environmental factors operating across the life course. +2 more findings

• Lifestyle
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

HẠT NANO VÀNG VỎ ĐỒNG VÀ SINH PHẨM TÁI TỔ HỢP: TRIỂN VỌNG CHO XÉT NGHIỆM NHANH ĐỘ NHẠY CAO

27/100 ✓ Peer-reviewed Tau biomarkers Tạp chí Y Dược học Cần Thơ

Key finding: Bài tổng quan này phân tích cơ chế kỹ thuật xét nghiệm kháng nguyên bằng sự hình thành vỏ nano đồng trên hạt vàng, trong đó ion Cu²⁺ được khử bởi natri ascorbate trên bề mặt AuNPs với vai trò ổn định của polyethylenimine, tạo cấu trúc Au-Cu đa giác giúp tăng cường tín hiệu plasmon. +4 more findings

Full summary, score breakdown and related studies → Original source

How does palliative care fit into national health spending? A secondary analysis of trends in long-term healthcare expenditure in the United Kingdom

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: Real-terms UK government spending on health-related long-term care grew by £6.4 billion (22.9%) between 2013 and 2022, from £27.9 to £34.3 billion. +2 more findings

• Policy
• End-of-Life Care

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

48/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications

Key finding: To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source