Newest studies

Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease: A Randomized Clinical Trial

70/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: Sixty consecutive patients with prodromal or mild AD were screened; 50 were randomized to gamma or sham tACS (mean [SD] age, 67.3 [7.8] years; 25 [50.0%] female and 25 [50.0%] male). +4 more findings

• Clinical Trials

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Posttreatment Amyloid Levels and Clinical Outcomes Following Donanemab for Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ 2 Randomized Clinical Trial

76/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Reduction of amyloid via amyloid-targeting therapies may result in clinical benefit. +1 more finding

• Clinical Trials
• Treatments

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Liraglutide in mild to moderate Alzheimer's disease: a phase 2b clinical trial

78/100 ✓ Peer-reviewed Clinical trials Nature Medicine

Key finding: The primary outcome showed no significant differences in cerebral glucose metabolism (difference = -0.17; 95% confidence interval: -0.39 to 0.06; P = 0.14) between the two groups. +2 more findings

• Clinical Trials
• Brain Scans

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Avaliação do Papel da Proteína Tau no Diagnóstico Precoce e Monitoramento do Alzheimer

25/100 ✓ Peer-reviewed Tau biomarkers Revista JRG de Estudos Acadêmicos

Key finding: Com isso, essa revisão integrativa analisou estudos publicados a partir de 2020 a 2025. +4 more findings

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Assessing outer retinal and choroidal changes in scd: potential for high-risk screening using SS-OCTA

54/100 ✓ Peer-reviewed Brain scans and imaging Translational psychiatry

Key finding: Compared with normal controls, individuals with SCD exhibited a significant increase in the choroidal vessel index and a reduction in outer retinal thickness. +3 more findings

• Diagnosis
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: insights from a clinical case series

48/100 ✓ Peer-reviewed Tau biomarkers Arquivos de neuro-psiquiatria

Key finding: Two patients presented with rapidly progressive dementia that fulfilled CAA-ri criteria. +4 more findings

• Biomarkers

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Serum p-tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

63/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: Serum p-tau217 levels were increased in individuals with iRBD and cognitive impairment (CI) on testing defined as Montreal Cognitive Assessment <26 or subthreshold parkinsonism. p-Tau217 differentiated individuals with iRBD who developed PD with CI (PD-CI) or DLB from PD phenoconverters with normal cognition (area under curve [AUC] = 0.82; 95% confidence interval, 0.70-0.93) and from iRBD non-phenoconverters with normal cognition (AUC = 0.83; 95% confidence interval, 0.77-0.89). +3 more findings

• Biomarkers

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Trends in Hospice Use Among Older Adults With Dementia and Cancer by Race and Ethnicity 2011–2021

37/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Hospice use (2011-2021) for decedents with cancer and dementia by ethnic and racial groups.

• End-of-Life Care
• Health Equity

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Age at diabetes diagnosis, genetic susceptibility and dementia risk: a prospective study of 13,126 participants from the UK Biobank

37/100 ✓ Peer-reviewed Long-term cohort studies Medicine Plus

Key finding: (1) Individuals diagnosed at ages 50–60 (hazard ratio (HR) = 0.71, 95% CI: 0.55–0.93, P = 0.0117) and > 60 years (HR = 0.59, 95% CI: 0.44–0.79, P < 0.001) had significantly lower ACD risk compared to those diagnosed at age < 50 years. +3 more findings

• Risk Factors
• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

Global burden of Alzheimer disease and other dementias reveals escalating geographical disparities and metabolic risks: A comprehensive analysis of 1990–2021 data

34/100 ✓ Peer-reviewed Disparities Medicine

Key finding: Notably, China saw significant increases in incidence, prevalence, and years lived with disability, while Indonesia and Eritrea reported the highest rises in deaths and years of life lost, respectively. +1 more finding

• Health Equity

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Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias

40/100 ✓ Peer-reviewed Getting a diagnosis Seminars in Neurology

Key finding: Large language models show promise as collaborative partners, helping clinicians interpret complex data while supporting patients and caregivers. +4 more findings

• Diagnosis
• Digital Tools

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Magnetic resonance imaging eligibility for anti‐amyloid monoclonal antibody treatment for Alzheimer disease: a single‐centre retrospective review for service planning

30/100 ✓ Peer-reviewed Treatments Internal Medicine Journal

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Delirium superimposed on dementia (DSD)—a practical approach

57/100 ✓ Peer-reviewed Genetics Age and Ageing

Key finding: DSD is linked to adverse outcomes, compared to dementia alone, like longer hospitalisation [3], mortality [3, 4], functional decline [3] and need for residential care [3]. +3 more findings

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Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer

54/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: Among survivors treated with CNS-directed therapy, higher EAA, measured by PCGrimAge, or DunedinPACE is associated with worse performance on multiple measures of attention, processing speed, and executive functions (p's < 0.05). +2 more findings

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Catatonia in the medically ill and dying: a review for palliative care clinicians

36/100 ✓ Peer-reviewed End-of-life care Annals of Palliative Medicine

Key finding: While commonly associated with psychiatric disorders, it is increasingly recognized in medically ill populations, including patients with serious illness.

• End-of-Life Care

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Evidenzlage zu Advance Care Planning bei Menschen mit Demenz – Ein systematisches Review (2017–2023)

31/100 ✓ Peer-reviewed End-of-life care Das Gesundheitswesen

Key finding: The studies demonstrated positive effects of Advance Care Planning on various domains for individuals with dementia and their caregivers. +1 more finding

• End-of-Life Care

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Associations of Individual Beverage Types and Substitution with Dementia Risk: A UK Biobank Cohort Study

52/100 ✓ Peer-reviewed Long-term cohort studies The journal of nutrition health & aging

Key finding: Over 13.45 years, 992 all-cause dementia cases were recorded. +4 more findings

• Risk Factors
• Prevention

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Alzheimer und Tumoren – eine komplexe Beziehung

32/100 ✓ Peer-reviewed Genetics Onkologische Welt

Key finding: Neben ihrer Wirkung auf Gewichtskontrolle und kardiometabolische Parameter könnten GLP-1RA auch die endokrine Funktion von Adipozyten sowie die chronische Inflammation bei der Adipositas und damit die Entstehung adipositasassoziierter Tumoren modulieren. +4 more findings

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Trends in Alzheimer’s Disease Mortality in the Mississippi Delta, 2016–2022

30/100 ✓ Peer-reviewed Risk factors Journal of dementia and Alzheimer's disease

Key finding: From 2016 to 2022, Alzheimer’s disease mortality significantly increased among Black individuals (AAPC = 8.3%, 95% CI [2.6 to 16.0]; p < 0.05) and declined among White individuals (AAPC = −2.9%, 95% CI [−12.3 to 7.6] p < 0.05). +4 more findings

• Health Equity

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Effectiveness of Advance Care Planning for End-of-Life Outcomes in Nursing Home Residents With Dementia: A Systematic Review and Meta-Analysis

52/100 ✓ Peer-reviewed Caregiving Journal of the American Medical Directors Association

Key finding: Although ACP programs in nursing homes may increase DNR directives, evidence of other EoL outcomes remains limited and inconsistent. +4 more findings

• End-of-Life Care
• Care Services

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Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1

63/100 ✓ Peer-reviewed Genetics The Lancet Healthy Longevity

Key finding: The apolipoprotein E (APOE) gene is the best established genetic risk factor for Alzheimer's disease in later life, with the ε4 allele conferring higher risk. +4 more findings

• Genetics
• Early Stage
• Prevention

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Dietary fiber modulates gut microbiota and lipid metabolism ameliorating Alzheimer's pathology in 5xFAD mice

43/100 ✓ Peer-reviewed Disease mechanisms Scientific reports

Key finding: Fecal lipidomics revealed significant shifts in phospholipids and long-chain fatty acids, while short-chain fatty acid levels showed only modest, taxa-specific changes. +1 more finding

• Brain Biology
• Lifestyle

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Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging

43/100 ✓ Peer-reviewed Genetics Cell reports

Key finding: However, transcriptomic analyses across fifteen mouse brain regions revealed that the cerebellum undergoes some of the earliest and most pronounced age-related changes. +2 more findings

• Brain Biology

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Diagnostic utility of plasma p-tau217 differs by Alzheimer's disease tau-based subtypes

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Four subtypes were identified: limbic, medial temporal lobe (MTL) sparing, posterior, and lateral temporal (l temporal). +4 more findings

• Biomarkers
• Diagnosis

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Organ-specific proteomic aging clocks predict disease and longevity across diverse populations

57/100 ✓ Peer-reviewed Disease mechanisms Nature Aging

Key finding: Organ aging reflected both genetic and environmental determinants: brain aging was associated with lifestyle, the GABBR1 and ECM1 genes, and brain structure.

• Genetics

Full summary, score breakdown and related studies → Original source