Newest studies

A new era in neuropharmacology: assessing the efficacy and safety of novel anti-amyloid and non-amyloid drug targets for Alzheimer's disease

39/100 ✓ Peer-reviewed Treatments Journal of Neurology

Key finding: Although β-site APP-cleaving enzyme 1 (BACE1) and secretase inhibitors did not achieve success in clinical trials because of mechanism-based toxicity and cognitive impairment, new monoclonal antibodies such as lecanemab and donanemab have shown high amyloid plaque clearance and reduced cognitive deterioration. +4 more findings

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

ADAM10 and its role in Alzheimer disease

29/100 ✓ Peer-reviewed Genetics Neurología (English Edition)

Key finding: ADAM10 plays a fundamental role in brain function, and sufficient studies support its involvement in AD pathogenesis. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Differences in amyloid PET positivity based on ethnoracial group and social determinants of health: The new IDEAS study

46/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Among 5757 participants (21.7% Black, 20.3% Latinx, 58.1% AORE), we found lower odds of amyloid positivity in Black (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.62-0.83) and Latinx (OR: 0.78, 95% CI: 0.67-0.91) compared to AORE. +3 more findings

• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

Global, Regional and Country-Specific Burden of Dementia Associated with Depression Across the Life-course

33/100 ✓ Peer-reviewed Risk factors Figshare

Key finding: MDD prevalence was consistently higher among women than men across all regions and age groups, ranging from 4.42%-5.11% in women versus 2.87%-3.41% in men. +3 more findings

Full summary, score breakdown and related studies → Original source

Associations of blood biomarkers of glial cell dysfunction and neuronal injury with future cognitive decline and incident dementia

41/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher serum GFAP, YKL-40, sCD14, and NfL were associat +3 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults: A Randomized Clinical Trial

67/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: In this multicenter randomized clinical trial among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, IRVR, or both did not result in statistically significant differences in improvements in cognitive function over 24 months. +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Value-based prices of emerging disease-modifying therapies for Alzheimer's disease in 174 countries: a cost-effectiveness and threshold analysis

43/100 ✓ Peer-reviewed Costs and economics Alzheimer's & Dementia

Key finding: VBPs indicate how much 174 countries should be willing to pay. +1 more finding

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation study

54/100 ✓ Peer-reviewed Treatments The lancet. Healthy longevity

Key finding: Guidelines recommend limiting antipsychotic treatment to short-term use (<12 weeks), followed by tapering and cessation. +2 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Aging in Place - A mixed methods study protocol of how care providers in Sweden organise and adapt granted home care services to the preferences and needs of people living with dementia

41/100 ✓ Peer-reviewed Health systems and care delivery PloS one

Key finding: The project focuses on: 1) what specific social care services older persons living at home with dementia are granted; if a dementia diagnosis is needed for some services; and the differences between municipalities; 2) how care providers organize granted services and adapt them to people living with dementia; including differences between municipalities and care provider units; 3) how care recipients living with dementia (including co-habiting partners) experience and influence the receiving of services. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Optimizing Approaches in Advance Care Planning in Dementia as Perceived by General Practitioners

34/100 ✓ Peer-reviewed End-of-life care Journal of Pain and Symptom Management

Key finding: Four attributes distinguished situations in which either approach is preferred: understanding, trust, readiness, and momentum. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The Gut Microbiota as a Mediator Linking the MIND Diet to Alzheimer’s Disease

36/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has emerged as a promising dietary pattern associated with reduced Alzheimer's disease (AD) risk, supported by growing evidence that both diet and the gut microbiota are modifiable contributors to disease development and progression.

• Lifestyle

Full summary, score breakdown and related studies → Original source

Outcome associations of CSF total tau in suspected non-Alzheimer pathophysiology

42/100 ✓ Peer-reviewed Tau biomarkers Journal of neurology

Key finding: Cognitively impaired patients with negative biomarkers of amyloidosis but with neurochemical evidence of Tau pathophysiology or neurodegeneration or both are classified as "suspected non-Alzheimer pathophysiology" (SNAP), according to the 2018 research framework for a biological definition of Alzheimer's disease (AD). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease

50/100 ✓ Peer-reviewed Genetics American Journal of Human Genetics

Key finding: Overall, multi-population eQTL fine-mapping improves model interpretability and helps resolve shared and population-specific regulatory mechanisms relevant to AD.

• Genetics

Full summary, score breakdown and related studies → Original source

Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults

47/100 ✓ Peer-reviewed Prevention trials Frontiers in Nutrition

Key finding: MCI patients showed significantly reduced plasma levels of TGF-β1 and increased TNF-α concentrations compared to other participants. +4 more findings

• Lifestyle
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer’s disease, Down syndrome, and Parkinson’s disease

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's npj Dementia

Key finding: For these neurodegenerative dementias, we observed that the chronological age did not align with their biological age, which was determined based on hippocampal transcript levels (i.e., transcriptional age). +2 more findings

• Down Syndrome
• Other Dementias

Full summary, score breakdown and related studies → Original source

PET-guided Assessment of Amyloid Clearance and Outcomes in a Real-World Cohort of Patients with Alzheimer Disease undergoing Anti-Amyloid Therapy

45/100 ✓ Peer-reviewed Genetics American Journal of Neuroradiology

Key finding: Thirty-two patients met inclusion criteria (lecanemab, N=15; donanemab, N=17). +4 more findings

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Plasma Biomarkers and Clinical Outcomes in Early-Onset Dementia

54/100 ✓ Peer-reviewed Biomarkers JAMA Network Open

Key finding: A total of 322 participants with p-tau217, GFAP, and NfL analyses were stratified into the EOAD or FTD group based on their diagnosis. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Undiagnosed dementia and mortality among older adults in the United States and Brazil: A cross-national cohort study

54/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

Key finding: Undiagnosed dementia is common and associated with increased mortality, identifying a vulnerable population missed by current diagnostic pathways. +2 more findings

Full summary, score breakdown and related studies → Original source

Gaps in Vascular Evaluation Before Major Lower-Extremity Amputation Among Medicare Beneficiaries With Chronic Limb-Threatening Ischemia

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: Among 10,666 patients (mean age 76.6 years; 35% female; 70% White, 21% Black), phenotype distribution was: A, 9.4%; B, 7.1%; C, 50.7%; D, 32.7%. +4 more findings

• Policy

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants

61/100 ✓ Peer-reviewed Risk factors Nature communications

Key finding: Here, utilizing data from 383,421 participants in the UK Biobank, we identify significant associations between social isolation, loneliness, and the incidence of 11 neurological and psychiatric disorders, including major depressive disorder (MDD), schizophrenia, bipolar disorder, anxiety disorders, sleep disorders, dementia, Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, and epilepsy employing Cox regression models. +2 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

System changes to empower primary care in Alzheimer's disease detection and care

39/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Despite advances in disease-modifying treatments, significant barriers in the evaluation and clinical management of people with early Alzheimer's disease (AD) remain.

• Care Services

Full summary, score breakdown and related studies → Original source

Acetylcholinesterase inhibitors and the risk of delirium – a Danish nationwide register-based cohort study

44/100 ✓ Peer-reviewed Clinical safety Alzheimer s Research & Therapy

Key finding: Among 45,651 patients, 311 delirium events occurred among continuous users and 84 among early discontinuers, corresponding to incidence rates of 66 and 112 events per 10,000 person-years, respectively. +4 more findings

Full summary, score breakdown and related studies → Original source

Agitation Severity and Psychotropic Prescription in Acute Patients With Delirium Superimposed on Dementia

42/100 ✓ Peer-reviewed Clinical safety Psychogeriatrics

Key finding: Compared with dementia alone, DSD was associated with higher PAS scores (5.3 vs. 4.0, p < 0.001), poorer functional status (FIM 48.6 vs. 57.8, p < 0.001) and more frequent in-hospital falls (29.9% vs. 17.5%, p < 0.001). +4 more findings

Full summary, score breakdown and related studies → Original source

Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer’s disease and non-Alzheimer’s dementias

38/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neuroscience

Key finding: In the AD and non-AD group, OEF showed negative associations with WMH in DGM and positive associations with MoCA in DGM and CGM. +1 more finding

Full summary, score breakdown and related studies → Original source

The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)

46/100 ✓ Peer-reviewed Prevention and risk PLoS Medicine

Key finding: Dementia is a leading health policy challenge, with cases expected to triple by 2050, particularly in low- and middle-income countries. +1 more finding

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source