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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Event-related potentials (ERPs), particularly the P200 component, have been studied as potential biomarkers, but conventional grand-averaged approaches often yield inconsistent results. This study examined the temporal dynamics of prefrontal ERPs in a large cohort of older adults to assess neural adaptation processes associated with early cognitive decline. Time–trial plots revealed blurred and attenuated P200 responses in aMCI patients, whereas the responses of cognitively normal (CN) participants remained relatively stable. Although the time × group interaction was not significant, a significant main effect of time was primarily driven by aMCI. Post hoc pairwise comparisons revealed significant decreases in TAP2A beginning at the 12th epoch, with a medium-to-large effect size (partial η² = 0.101). The group comparison revealed significant differences between the CN and aMCI groups in later time bins (epochs 12–18, p < 0.01). aMCI was associated with accelerated neural adaptation, reflected by trial-by-trial reductions in TAP2A that may indicate altered attentional allocation and reduced neural efficiency. Compared with static measures, temporal dynamics appeared more sensitive to group-related differences among aMCI, CN, and naMCI participants. These findings suggest that slope-based temporal indices may hold exploratory potential as noninvasive indicators of memory-related cognitive change, complementing neuropsychological assessments and contributing to the early characterization of individuals who may be at increased risk of developing AD.

Key findings

Event-related potentials (ERPs), particularly the P200 component, have been studied as potential biomarkers, but conventional grand-averaged approaches often yield inconsistent results.
This study examined the temporal dynamics of prefrontal ERPs in a large cohort of older adults to assess neural adaptation processes associated with early cognitive decline.
Time–trial plots revealed blurred and attenuated P200 responses in aMCI patients, whereas the responses of cognitively normal (CN) participants remained relatively stable.
Although the time × group interaction was not significant, a significant main effect of time was primarily driven by aMCI.
Post hoc pairwise comparisons revealed significant decreases in TAP2A beginning at the 12th epoch, with a medium-to-large effect size (partial η² = 0.101).

Why it matters

In a large cohort of older adults, patients with amnestic mild cognitive impairment showed blurred and attenuated P200 responses and accelerated neural adaptation compared with cognitively normal participants. These findings suggest slope-based temporal indices may hold exploratory potential as noninvasive indicators, not a treatment or cure.

Study details

Participants636
Evidence strengthModerate

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	2 / 4	636 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 4.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Jaeuk U. Kim: h-index 23 (OpenAlex, whole career)
Institution's track record	0 / 3	Korea Research Institute of Bioscience and Biotechnology: institution h-index 357 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41501935)
Free to read	2 / 2	Free to read
Total	43 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Bae, J.-H., Choi, M., Lee, K. H., & Kim, J. U. (2026). Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01940-2

Vancouver

Bae J.-H, Choi M, Lee KH, Kim JU. Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment. Alzheimer s Research & Therapy. 2026. doi:10.1186/s13195-025-01940-2. PMID: 41501935.

BibTeX

@article{bae2026-41501935,
  author  = {Bae, Jang-Han and Choi, Minho and Lee, Kun Ho and Kim, Jaeuk U.},
  title   = {{Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2026},
  doi     = {10.1186/s13195-025-01940-2},
  pmid    = {41501935},
  url     = {https://doi.org/10.1186/s13195-025-01940-2}
}

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