Home › Research › Prevention trials
The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk
Veerle van Gils, Lisa Waterink, S. C. P. M. Wimmers, J.G.M. Jelsma, Marjolein Elizabeth de Vugt, Ron L. H. Handels, Sietske A.M. Sikkes, Wiesje M. van der Flier et al.. Alzheimer s Research & Therapy, 2026-01-08
Topic: Risk, prevention and care in population studies
LIGHT will provide insight into the implementation and (cost-)effectiveness of a lifestyle intervention for indicated prevention in a memory clinic setting. TRIAL REGISTRATION: Clinicaltrials.gov: NCT06832761 (date 2025-02-18), OMON: 57,198.
Key findings
- LIGHT will provide insight into the implementation and (cost-)effectiveness of a lifestyle intervention for indicated prevention in a memory clinic setting.
- TRIAL REGISTRATION: Clinicaltrials.gov: NCT06832761 (date 2025-02-18), OMON: 57,198.
Why it matters
This describes the design of a randomized controlled trial that will test a lifestyle intervention in memory clinics to reduce modifiable dementia risk. No results are available yet, so it cannot yet say whether the intervention prevents dementia.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designrandomized controlled trial
- Evidence strengthHigh
How this study scored 55/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 53 of the 96 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 4 / 6 | Cited 9.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author N. Janssen holds only 3 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 1 / 3 | Karolinska Institutet: institution h-index 1,477 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41508135) |
| Free to read | 2 / 2 | Free to read |
| Points | 53 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 53 of the 96 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-025-01947-9
- PubMed: 41508135
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
van Gils, V., Waterink, L., Wimmers, S. C. P. M., Jelsma, J., de Vugt, M. E., Handels, R. L. H., et al. (2026). The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01947-9
Vancouver
van Gils V, Waterink L, Wimmers SCPM, Jelsma J, de Vugt ME, Handels RLH, et al. The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk. Alzheimer s Research & Therapy. 2026. doi:10.1186/s13195-025-01947-9. PMID: 41508135.
BibTeX
@article{vangils2026-41508135,
author = {van Gils, Veerle and Waterink, Lisa and Wimmers, S. C. P. M. and Jelsma, J.G.M. and de Vugt, Marjolein Elizabeth and Handels, Ron L. H. and Sikkes, Sietske A.M. and van der Flier, Wiesje M. and others},
title = {{The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk}},
journal = {Alzheimer s Research \& Therapy},
year = {2026},
doi = {10.1186/s13195-025-01947-9},
pmid = {41508135},
url = {https://doi.org/10.1186/s13195-025-01947-9}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.