Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,576–18,600 of 27,380 studies, newest first · page 744 of 1096.
July 2013 20
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2013-07-01
Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force
40/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: An international task force of investigators from academia, industry, nonprofit foundations, and regulatory agencies met in Monte Carlo, Monaco, on October 31, 2012, to review lessons learned from the recent bapineuzumab and solanezumab trials, and to incorporate insights gained from these trials into future clinical studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Brain health and exercise in older adults
36/100 ✓ Peer-reviewed Prevention trials Current sports medicine reports
Key finding: Evidence suggests that exercise and cognitive training benefit cognitive health in older adults; however, a preferred modality has to be endorsed yet by the scientific community. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-01
Mediterranean diet and cognitive function in older age
67/100 ✓ Peer-reviewed Prevention trials Epidemiology (Cambridge, Mass.)
Key finding: In this large study of older women, we observed no association of the Mediterranean diet with cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Psychosis in Children and Youth: Focus on Early-Onset Schizophrenia
32/100 ✓ Peer-reviewed Risk factors Pediatrics in Review
Key finding: In the history of psychiatry, the words mad and psychosis have often been used interchangeably, negatively contributing to the stigma associated with the term and the illness itself. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
O4–04–05: Geographical variation in dementia prevalence in Swedish twins: Using Bayesian inference to separate genetic and environmental effects
39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: The smoothed area odds ratio of dementia, after adjusting for age and twin random effects, showed a marked south-north gradient, with increased risk in the north in both men and women (See Figure.).
Full summary, score breakdown and related studies → Original source
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2013-07-01
O4–04–02: Prevalence studies of dementia in mainland China, Hong Kong and Taiwan: A systematic review and meta‐analysis
49/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: However, the influence of methodological factors on the results is seldom considered in these reviews and area prevalence has not been estimated adjusting comprehensively for various research methods between the studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
PC‐009: Integrated medical and case management dementia model
29/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia
Key finding: With almost twenty percent of the population in western North Carolina over age 65 compared to thirteen percent in the rest of the state and country, the need for such a program came sooner than in many communities.
Full summary, score breakdown and related studies → Original source
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2013-07-01
Effects of anesthetic isoflurane and desflurane on human cerebrospinal fluid Aβ and τ level
58/100 ✓ Peer-reviewed Tau biomarkers Anesthesiology
Key finding: Accumulation of β-amyloid protein (Aβ) and tau protein is the main feature of Alzheimer disease neuropathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
The importance of tau phosphorylation for neurodegenerative diseases
49/100 ✓ Peer-reviewed Lewy body dementia Frontiers in neurology
Key finding: Increasing evidence suggests that the presence of these end-stage neurofibrillary lesions do not cause neuronal loss, but rather that alterations to soluble tau proteins induce neurodegeneration. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-01
Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture
45/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: Review of clinical and biological features of primary progressive aphasia (PPA). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-07-01
Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons
72/100 ✓ Peer-reviewed How common it is Sleep
Key finding: Sleep fragmentation in older adults is associated with incident AD and the rate of cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Improving access to dementia services for people from minority ethnic groups
41/100 ✓ Peer-reviewed Disparities Current opinion in psychiatry
Key finding: Only a minority of people with dementia receive a formal diagnosis despite a growing body of evidence highlighting the benefits of early diagnosis and intervention.
Full summary, score breakdown and related studies → Original source
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2013-07-01
Caregiver health: health of caregivers of Alzheimer's and other dementia patients
42/100 ✓ Peer-reviewed Caregiving Current psychiatry reports
Key finding: Alzheimer's disease (AD) is the most common type of dementia and is a significant public health problem that will intensify as the population ages. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Imaging markers for Alzheimer disease: which vs how
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Markers accounted for 11% and 18% of diagnostic and prognostic variance of LR+ and 16% and 24% of LR-. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus
62/100 ✓ Peer-reviewed Getting a diagnosis JAMA internal medicine
Key finding: During the 12-year follow-up period, 61 participants (7.8%) had a reported hypoglycemic event, and 148 (18.9%) developed dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Is there evidence for cognitive intervention in Alzheimer disease? A systematic review of efficacy, feasibility, and cost-effectiveness
50/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Several studies have shown that cognitive intervention may be beneficial for people with Alzheimer disease (AD), but literature reviews conducted so far, have yielded mixed and inconclusive results. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging
64/100 ✓ Peer-reviewed Treatments JAMA neurology
Key finding: TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00257712.
Full summary, score breakdown and related studies → Original source
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2013-07-01
Mediterranean diet, cognitive function, and dementia: a systematic review
66/100 ✓ Peer-reviewed Treatments Epidemiology (Cambridge, Mass.)
Key finding: Published studies suggest that greater adherence to Mediterranean diet is associated with slower cognitive decline and lower risk of developing Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature
49/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-07-01
Update on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education. Amyloid Imaging Task Force of the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging
47/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. +2 more findings
Full summary, score breakdown and related studies → Original source
June 2013 5
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2013-06-30
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
40/100 ✓ Peer-reviewed Risk factors Nature immunology
Key finding: Collectively, our findings highlight the importance of CD36 in the accrual and nucleation of NLRP3 ligands from within the macrophage and position CD36 as a central regulator of inflammasome activation in sterile inflammation.
Full summary, score breakdown and related studies → Original source
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2013-06-29
Recent advances in the application of metabolomics to Alzheimer's Disease
36/100 ✓ Peer-reviewed Treatments Biochimica et biophysica acta
Key finding: The pathophysiological changes associated with Alzheimer's Disease (AD) begin decades before the emergence of clinical symptoms. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-29
CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease
61/100 ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica
Key finding: In addition, AD and LBD are often found in the same patients at autopsy; therefore, biomarkers that can detect the presence of both pathologies in living subjects are needed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-29
Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI
55/100 ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica
Key finding: To clarify this issue, we analyzed the longitudinal CSF tau and Aβ biomarker data from 142 of the AD Neuroimaging Initiative (ADNI) study subjects [18 AD, 74 mild cognitive impairment (MCI), and 50 cognitively normal subjects (CN)]. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-28
Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Furthermore, these behavioral impairments were associated with reduced hippocampal volume and multiple cellular alterations such as chronic reductions in neural stem cell activity and neurogenesis, partial loss of principal neurons, and mild inflammation comprising sporadic occurrence of activated microglia and significant hypertrophy of astrocytes. +1 more finding
Full summary, score breakdown and related studies → Original source
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