Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,576–17,600 of 27,380 studies, newest first · page 704 of 1096.
October 2014 25
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2014-10-05
Rationale and design of a multicenter, phase 2 clinical trial to investigate the efficacy of traditional Chinese medicine SaiLuoTong in vascular dementia
53/100 ✓ Peer-reviewed Treatments Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Key finding: The rigorous methodology of the study will hopefully move forward the scientific evaluation of traditional Chinese medicine in treatment of VaD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-03
Multiple anticholinergic medication use and risk of hospital admission for confusion or dementia
57/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Taking more anticholinergic medications is associated with greater risk of hospitalization for confusion or dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-02
Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
45/100 ✓ Peer-reviewed Clinical trials Journal of Psychopharmacology
Key finding: One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-02
The Thoughts Questionnaire (TQ) for family caregivers of people with dementia
45/100 ✓ Peer-reviewed Caregiving Dementia (London, England)
Key finding: The level of agreement with dysfunctional thought statements from the Dementia Thoughts Caregivers Questionnaire and Thoughts Questionnaire was low. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-02
Neuroprotective action of resveratrol
36/100 ✓ Peer-reviewed Vascular contributions Biochimica et biophysica acta
Key finding: Besides its well documented free radical scavenging and anti-inflammatory properties, resveratrol has been shown to increase the clearance of beta-amyloid, a key feature of Alzheimer's disease, and to modulate intracellular effectors associated with oxidative stress (e.g. heme oxygenase), neuronal energy homeostasis (e.g.
Full summary, score breakdown and related studies → Original source
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2014-10-02
What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?
40/100 ✓ Peer-reviewed TREM2 and immune genetics Neuroscience
Key finding: In the adult brain, these include maintenance of homeostasis, neuron and tissue repair, and eliminating infectious agents, apoptotic cells, and misfolded proteins. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
START (STrAtegies for RelaTives) study: a pragmatic randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of a manual-based coping strategy programme in promoting the mental health of carers of people with dementia
16/100 ⚠ Report — not peer-reviewed Costs and economics Health Technology Assessment
Key finding: Two hundred and sixty participants were randomised (173 intervention, 87 TAU). +4 more findings
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2014-10-01
Infection management and multidrug-resistant organisms in nursing home residents with advanced dementia
59/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine
Key finding: The cohort experienced 496 suspected infections; 72.4% were treated with antimicrobials, most commonly quinolones (39.8%) and third- or fourth-generation cephalosporins (20.6%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
The role of iron in brain ageing and neurodegenerative disorders
40/100 ✓ Peer-reviewed Vascular contributions The Lancet. Neurology
Key finding: During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-10-01
CDC National Health Report: leading causes of morbidity and mortality and associated behavioral risk and protective factors--United States, 2005-2013
40/100 ✓ Peer-reviewed Prevention trials MMWR supplements
Key finding: The findings in this report indicate that progress has been steady but slow for many of the priority health issues in the United States. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance
52/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: For T1-weighted MRI acquired from 288 participants in a multi-centre clinical trial in Alzheimer's disease we find a high correlation between SPM12 TIV and manual TIV (R(2)=0.940, 95% Confidence Interval (0.924, 0.953)), with a small mean difference (SPM12 40.4±35.4ml lower than manual, amounting to 2.8% of the overall mean TIV in the study). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Feasibility and validity of the self-administered computerized assessment of mild cognitive impairment with older primary care patients
48/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer disease and associated disorders
Key finding: These results support the feasibility of using self-administered computerized cognitive tests with older primary care patients, given the increasing reliance on computers by people of all ages.
Full summary, score breakdown and related studies → Original source
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2014-10-01
Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2014-10-01
A randomized trial to measure the impact of a community-based cognitive training intervention on balance and gait in cognitively intact Black older adults
71/100 ✓ Peer-reviewed Prevention trials Health education & behavior : the official publication of the Society for Public Health Education
Key finding: They provide initial evidence that cognitive training may be an efficacious approach toward improving balance and gait in older adults known to have a history of falls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Comprehensive Longitudinal Health Care in the Home for High‐Cost Beneficiaries: A Critical Strategy for Population Health Management
57/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Despite using more home health and hospital services than controls in the baseline preenrollment period, which suggests that they were sicker, participants receiving house calls had 17% lower overall Medicare costs than controls, and there was no indication of poorer quality of care, greater mortality, or underservice. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Alzheimer CSF biomarkers may be misleading in normal-pressure hydrocephalus
45/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: This article discusses why CSF biomarkers found in normal-pressure hydrocephalus (NPH) can be misleading when distinguishing NPH from comorbid NPH with Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Global differential expression of genes located in the Down Syndrome Critical Region in normal human brain
32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Colombia medica (Cali, Colombia)
Key finding: The precise regulation of DSCR gene expression is crucial to maintain the brain homeostasis, especially in those areas with high levels of gene expression associated with a remarkable process of learning and cognition. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain
45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Biochemical journal
Key finding: In particular, we focus attention on dysregulated pathways that underlie neurodegeneration in both aging adults with DS (Down's syndrome) and AD (Alzheimer's disease). +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
Connections between sleep and cognition in older adults
55/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: These findings suggest that the sleep-wake cycle plays a crucial part in brain ageing, pointing to a potential avenue for improvement of cognitive outcomes in people at risk of cognitive decline and dementia.
Full summary, score breakdown and related studies → Original source
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2014-10-01
ALS and other motor neuron diseases
38/100 ✓ Peer-reviewed Digital health tools Continuum (Minneapolis, Minn.)
Key finding: TAR DNA binding protein 43 kDa (TDP-43), for instance, has been shown to cause frontotemporal dementia as well as some cases of familial ALS, and is associated with frontotemporal dysfunction in ALS.
Full summary, score breakdown and related studies → Original source
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2014-10-01
Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study
58/100 ✓ Peer-reviewed How common it is JAMA neurology
Key finding: Midlife hypertension and elevated midlife but not late-life systolic BP was associated with more cognitive decline during the 20 years of the study. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
The telehealth satisfaction scale: reliability, validity, and satisfaction with telehealth in a rural memory clinic population
43/100 ✓ Peer-reviewed Disparities Telemedicine journal and e-health : the official journal of the American Telemedicine Association
Key finding: The study findings demonstrate high user satisfaction with telehealth in a rural memory clinic and the sound psychometric properties of the TeSS in this population. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-10-01
Nonalcoholic fatty liver disease and aging: epidemiology to management
44/100 ✓ Peer-reviewed Caregiving World journal of gastroenterology
Key finding: In conclusion, further epidemiological and pathophysiological insight is warranted.
Full summary, score breakdown and related studies → Original source
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2014-10-01
Mild cognitive impairment and mild dementia: a clinical perspective
52/100 ✓ Peer-reviewed Getting a diagnosis Mayo Clinic proceedings
Key finding: The etiology of mild cognitive impairment and mild dementia can often be established through the clinical examination, although imaging and other laboratory tests may also contribute. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-10-01
3D-CAM: derivation and validation of a 3-minute diagnostic interview for CAM-defined delirium: a cross-sectional diagnostic test study
64/100 ✓ Peer-reviewed Getting a diagnosis Annals of internal medicine
Key finding: The 3D-CAM operationalizes the CAM algorithm using a 3-minute structured assessment with high sensitivity and specificity relative to a reference standard and could be an important tool for improving recognition of delirium. +1 more finding
Full summary, score breakdown and related studies → Original source
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