Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,951–18,975 of 27,380 studies, newest first · page 759 of 1096.
January 2013 25
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2013-01-07
Delirium in an adult acute hospital population: predictors, prevalence and detection
57/100 ✓ Peer-reviewed Getting a diagnosis BMJ open
Key finding: Using DSM-IV criteria, 55 of 280 patients (19.6%) had delirium versus 17.6% using the CAM.
Full summary, score breakdown and related studies → Original source
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2013-01-04
Resting state functional connectivity in preclinical Alzheimer's disease
36/100 ✓ Peer-reviewed Brain scans and imaging Biological psychiatry
Key finding: In addition, we discuss evidence for underlying preclinical AD mechanisms, including an important relationship between resting state functional connectivity and brain metabolism and how this results in a distinctive pattern of amyloid plaque deposition in default mode network regions.
Full summary, score breakdown and related studies → Original source
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2013-01-04
Cognitive disorders and dementia in CKD: the neglected kidney-brain axis
52/100 ✓ Peer-reviewed How common it is Journal of the American Society of Nephrology : JASN
Key finding: Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia.
Full summary, score breakdown and related studies → Original source
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2013-01-04
Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples
50/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: Thus, literature results are inconsistent and difficult to interpret. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-03
Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
43/100 ✓ Peer-reviewed Biomarkers Biochemical pharmacology
Key finding: The associations remained significant for CSF cholesterol and 24S-hydroxycholesterol when analyses were separately performed in the AD group. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-03
Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke
47/100 ✓ Peer-reviewed TREM2 and immune genetics PloS one
Key finding: Triggering receptor expressed on myeloid cells-2 (TREM2) is a microglial surface receptor involved in phagocytosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-03
Molecular neuropsychology: creation of test-specific blood biomarker algorithms
41/100 ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders
Key finding: Prior work on the link between blood-based biomarkers and cognitive status has largely been based on dichotomous classifications rather than detailed neuropsychological functioning.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging
40/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage Clinical
Key finding: Both VBA and ROI analyses revealed widespread group differences in FA and all diffusivity measures.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Diagnostic and statistical manual of mental disorders 5: A quick glance
64/100 ✓ Peer-reviewed Risk factors Indian Journal of Psychiatry
Key finding: The diagnostic criteria continued to result in rather frequent diagnosis of comorbidity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013 year only
Health insurance status and the care of nursing home residents with advanced dementia
70/100 ✓ Peer-reviewed Costs and economics JAMA internal medicine
Key finding: Residents enrolled in managed care (n = 133) were more likely to have do-not-hospitalize orders compared with those in traditional Medicare fee for service (n = 158) (63.7% vs 50.9%; adjusted odds ratio, 1.9; 95% CI, 1.1-3.4), were less likely to be transferred to the hospital for acute illness (3.8% vs 15.7%; adjusted odds ratio, 0.2; 95% CI, 0.1-0.5), had more primary care visits per 90 days (mean [SD], 4.8 [2.6] vs 4.2 [5.0]; adjusted rate ratio, 1.3; 95% CI, 1.1-1.6), and had more nurse practitioner visits (3.0 [2.1] vs 0.8 [2.6]; adjusted rate ratio, 3.0; 95% CI, 2.2-4.1). +2 more findings
Full summary, score breakdown and related studies → Original source
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2013 year only
Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies
38/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD
Key finding: A significant proportion of patients with dementia with Lewy bodies (DLB) show Alzheimer's disease (AD) pathology like senile plaques and neurofibrillary tangles. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Adaptive downregulation of mitochondrial function in down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cell metabolism
Key finding: Sustained stimulation restored mitochondrial functional parameters but increased reactive oxygen species production and cell damage, suggesting that reduced DS mitochondrial activity is an adaptive response for avoiding injury and preserving basic cellular functions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-01
Atypical aging in Down syndrome
52/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Developmental disabilities research reviews
Key finding: At present, there may be over 210,000 people with Down syndrome (DS) over the age of 55 in the United States (US) who have significant needs for augmented services due to circumstances related to ordinary and/or pathological aging.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Potentially avoidable hospitalizations among Medicare beneficiaries with Alzheimer's disease and related disorders
52/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Medicare beneficiaries with ADRD were at a higher risk of PAHs for certain uncontrolled comorbidities and incurred higher Medicare expenditures compared with matched controls without dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Deep learning-based feature representation for AD/MCI classification
40/100 ✓ Peer-reviewed Digital health tools Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Key finding: In recent years, there has been a great interest in computer-aided diagnosis of Alzheimer's Disease (AD) and its prodromal stage, Mild Cognitive Impairment (MCI). +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Structural and functional characterization of two alpha-synuclein strains
43/100 ✓ Peer-reviewed Brain tissue and pathology Nature communications
Key finding: The association of protein aggregates made of a single protein with a variety of clinical phenotypes has been explained for prion diseases by the existence of different strains that propagate through the infection pathway. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Pericyte loss influences Alzheimer-like neurodegeneration in mice
13/100 ⚠ Retracted — do not rely on it Vascular contributions Nature communications
Key finding: Pericytes are cells in the blood-brain barrier that degenerate in Alzheimer's disease (AD), a neurological disorder associated with neurovascular dysfunction, abnormal elevation of amyloid β-peptide (Aβ), tau pathology and neuronal loss. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-01
Neuroactive insecticides: targets, selectivity, resistance, and secondary effects
36/100 ✓ Peer-reviewed Risk factors Annual review of entomology
Key finding: Currently, the four major nerve targets are acetylcholinesterase for organophosphates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the γ-aminobutyric acid receptor/chloride channel for polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Montreal cognitive assessment: validation study for mild cognitive impairment and Alzheimer disease
59/100 ✓ Peer-reviewed Risk factors Alzheimer disease and associated disorders
Key finding: The MoCA showed consistently superior psychometric properties compared with the MMSE, and higher diagnostic accuracy to discriminate between MCI (area under the curve=0.856; 95% confidence interval, 0.796-0.904) and AD patients (area under the curve=0.980; 95% confidence interval, 0.947-0.995). +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Anti-inflammatory therapy in chronic disease: challenges and opportunities
41/100 ✓ Peer-reviewed Risk factors Science (New York, N.Y.)
Key finding: As a result, redundancy, compensatory pathways, and necessity narrow the risk:benefit ratio of anti-inflammatory drugs.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Endoplasmic reticulum dysfunction in neurological disease
40/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: Endoplasmic reticulum (ER) dysfunction might have an important part to play in a range of neurological disorders, including cerebral ischaemia, sleep apnoea, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, the prion diseases, and familial encephalopathy with neuroserpin inclusion bodies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease
62/100 ✓ Peer-reviewed Drug development Current Alzheimer research
Key finding: In the evaluation phase, the treated group showed no decreased performance in the mini-mental state examination test, in opposition to the lower scores observed for the control group during the treatment, with significant differences starting three months after the beginning of the treatment, and increasing progressively.
Full summary, score breakdown and related studies → Original source
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2013-01-01
GSK3 and tau: two convergence points in Alzheimer's disease
36/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD
Key finding: Our data suggest that progression of the tauopathy can be prevented by administration of lithium when the first signs of neuropathology appear.
Full summary, score breakdown and related studies → Original source
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2013-01-01
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology
36/100 ✓ Peer-reviewed Treatments Journal of psychiatry & neuroscience : JPN
Key finding: Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and postmortem by neuritic plaques containing amyloid ß peptide and neurofibrillary tangles containing phospho-tau protein. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-01
Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study
71/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Responders in MMSE were significantly higher in the active group (p = 0.05). +1 more finding
Full summary, score breakdown and related studies → Original source
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