Newest studies

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We report CSF soluble TREM2 (sTREM2) and CSF chitinase-3-like protein 1 (CHI3L1/YKL-40) as PD biomarkers for the TREM2 agonist hPara.09. +4 more findings

• Genetics
• Biomarkers

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Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

46/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy

Key finding: The speech assessment was feasible, indicated by 91.6% adherence and usability scores of 86.0 ± 9.9. +3 more findings

• Early Stage

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Amyloid-Related Imaging Abnormalities in the Era of Anti-Amyloid Beta Monoclonal Antibodies for Alzheimer's Disease: Recent Updates on Clinical and Imaging Features and MRI Monitoring

45/100 ✓ Peer-reviewed Treatments Korean journal of radiology

Key finding: ARIA results from treatment-related disruption of vascular integrity and increased vascular permeability, leading to the leakage of proteinaceous fluid (ARIA-E) and heme products (ARIA-H).

• Treatments
• Brain Scans
• Side Effects

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Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment

70/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: In the discovery cohort, the mean (SD) age was 70.9 (8.5) years, 191 (58%) were male, the mean (SD) MMSE score was 27.1 (1.9), and 110 individuals with MCI (33%) converted to dementia (71 to AD dementia). +3 more findings

• Brain Scans
• Early Stage

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Parental History of Memory Impairment and β-Amyloid in Cognitively Unimpaired Older Adults

61/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: Of 4413 individuals (mean [SD] age, 71.27 [4.66] years, 2617 women [59.3%]), mean Aβ-PET was elevated in individuals with history of memory impairment in both parents (n = 455; mean [SD] standardized uptake value ratio [SUVR] = 1.12 [0.19]; Wilcoxon P = 1.1 × 10-5) and in those with only maternal history (n = 1772; mean [SD] SUVR = 1.10 [0.19]; Wilcoxon P = 2.70 × 10-5) compared with those with only paternal history (n = 632; mean [SD] SUVR = 1.08 [0.18]; Wilcoxon P = 1.1 × 10-5) or no family history (n = 1554; mean [SD] SUVR = 1.08 [0.19]; Wilcoxon P = 1.1 × 10-5). +2 more findings

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ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults: A Randomized Clinical Trial

70/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: In this 3-year randomized clinical trial, ω-3 treatment was safe and well-tolerated but failed to reach significant reductions in WML accumulation or neuronal integrity breakdown among all participants, which may be attributable to sample size limitations. +4 more findings

• Clinical Trials

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Optical Coherence Tomography Angiography Retinal Imaging Associations With Burden of Small Vessel Disease and Amyloid Positivity in the Brain

41/100 ✓ Peer-reviewed Biomarkers Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Key finding: The associations of lower foveal capillary density with cerebral WMH and amyloid positivity suggest that further research is warranted to evaluate for shared mechanisms of disease between small vessel disease and AD pathologies. +4 more findings

• Brain Scans
• Other Dementias

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Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers

60/100 ✓ Peer-reviewed Biomarkers JAMA psychiatry

Key finding: In the longitudinal analysis of p-tau181 trajectories of the AD+P group, the group of patients who showed incidence of psychosis over the course of follow-up (AD+P incident) demonstrated an associated increase in plasma p-tau181 levels compared with the group of patients who had psychosis at baseline (AD+P baseline) and showed an associated decrease in plasma p-tau181 levels (F4, 117 = 3.24; P = .01). +3 more findings

• Biomarkers

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Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology

67/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Among community-dwelling adults included in this study, higher fragmentation of the 24-hour activity rhythms was associated with greater subsequent Aβ burden, especially in APOE4 carriers. +4 more findings

• Lifestyle

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Care management improves total cost of care for patients with dementia

48/100 ✓ Peer-reviewed Costs and economics American Journal of Managed Care

Key finding: A collaborative dementia care program demonstrated significant financial benefit in a managed Medicare population. +3 more findings

• Policy

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Cataract Surgery and Cognitive Benefits in the Older Person: A Systematic Review and Meta-analysis

74/100 ✓ Peer-reviewed Prevention and risk Ophthalmology

Key finding: Meta-analysis of 24 studies, ~558,000 participants +3 more findings

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Diagnostic performance of light reflex pupillometry in Alzheimer's disease

63/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: HIGHLIGHTS: We demonstrated the diagnostic performance of qLRP in Alzheimer's disease.

• Diagnosis

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Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease

54/100 ✓ Peer-reviewed Biomarkers NPJ Parkinson's disease

Key finding: In the PD group, Aβ composite was associated with cognitive function, p-tau181 with motor function and non-motor symptoms, and NfL with cognitive and motor functions and non-motor symptoms. +1 more finding

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study

40/100 ✓ Peer-reviewed Tau biomarkers Journal of the American Heart Association

Key finding: The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. +3 more findings

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Assessing the Effectiveness of eHealth Interventions to Manage Multiple Lifestyle Risk Behaviors Among Older Adults: Systematic Review and Meta-Analysis

59/100 ✓ Peer-reviewed Treatments Journal of medical Internet research

Key finding: However, the effect sizes were small.

• Lifestyle
• Risk Factors

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CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

43/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: However, the identity and redundancy of aggrephagy receptors in recognizing substrates remain largely unexplored. +3 more findings

• Brain Biology
• Other Dementias
• Prevention

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Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

Key finding: Plasma A+/T + individuals showed the highest levels of astrocyte reactivity, Aβ plaque, tau tangle, and axonal degeneration, and the lowest hippocampal volume and temporal-metaROI cortical thickness. +4 more findings

• Brain Biology
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Examining Food Access Equity by Integrating Grocery Store Pricing into Spatial Accessibility Measures

36/100 ✓ Peer-reviewed Risk factors Transportation Research Record: Journal of the Transportation Research Board

Key finding: However, these measures do not always consider the pricing of food items, which can significantly affect food access for low-income individuals and families. +1 more finding

• Health Equity

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Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment

51/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: Isoprostanes and prostaglandins are biomarkers for oxidative stress and inflammation. +3 more findings

• Biomarkers
• Brain Biology
• Early Stage

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Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?

60/100 ✓ Peer-reviewed Genetics Journal of neuroinflammation

Key finding: Indeed, in our review, we observed a stage-dependent neuroinflammatory process in the AD brain. +1 more finding

• Treatments
• Brain Biology

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Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia

43/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing the underlying disease mechanisms better than GWAS loci. +1 more finding

• Genetics

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Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology

42/100 ✓ Peer-reviewed Biomarkers Frontiers in immunology

Key finding: Our data suggest that FXN ameliorates AD pathology, by simultaneously targeting two key pathological features: Aβ deposits and neuroinflammation. +4 more findings

• Brain Biology
• Treatments

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Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome

55/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Individuals with DS were more likely to have microbleeds than controls (20% vs 8.9%, p 60 years) and AD clinical stage (12.42% asymptomatic, 27.9% prodromal, 35.09% dementia) were more common in APOE ε4 carriers (26% vs 18.3% noncarriers, p = 0.008), but not associated with vascular risk factors ( p > 0.05). +3 more findings

• Biomarkers
• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

63/100 ✓ Peer-reviewed Risk genes beyond APOE The Lancet. Neurology

Key finding: A summary measure of γ-secretase activity (γ-secretase composite [GSC]) was calculated for each variant and compared with clinical history-derived AAO using correlation analyses. +2 more findings

• Genetics

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Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy

43/100 ✓ Peer-reviewed Disease mechanisms Communications biology

Key finding: We conducted transcriptomic analysis of tau transgenic and xbp-1s transgenic C. elegans and found 116 putative target genes significantly upregulated by constitutively active XBP-1s.

• Brain Biology

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