Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,076–20,100 of 27,380 studies, newest first · page 804 of 1096.
June 2011 24
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2011-06-14
Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementia
57/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology
Key finding: Forty-five AD patients were randomly classified into three groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-13
Longitudinal change of biomarkers in cognitive decline
60/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of neurology
Key finding: Trajectories of Aβ42 level in CSF, FDG uptake, and hippocampal volume vary across different cognitive stages. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-12
Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
41/100 ✓ Peer-reviewed Mild cognitive impairment Journal of chemical neuroanatomy
Key finding: Specifically, upregulation of rab4, rab5, rab7, and rab27 was observed in CBF neurons microdissected from postmortem brains of individuals with MCI and AD compared to age-matched control subjects with no cognitive impairment (NCI). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-12
Face-name associative memory performance is related to amyloid burden in normal elderly
53/100 ✓ Peer-reviewed Caregiving Neuropsychologia
Key finding: A significant inverse relationship for FN-N was found with Aβ deposition in frontal (R(2)=0.29, β=-2.2, p=0.02) and PPCLP cortices (R(2)=0.26, β=-2.4, p=0.05). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-11
Resting-state brain networks: literature review and clinical applications
36/100 ✓ Peer-reviewed Brain scans and imaging Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Key finding: Resting-state functional connectivity has revealed a number of networks which are consistently found in healthy subjects and represent specific patterns of synchronous activity.
Full summary, score breakdown and related studies → Original source
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2011-06-11
Parkinson's disease progression at 30 years: a study of subthalamic deep brain-stimulated patients
50/100 ✓ Peer-reviewed Clinical safety Brain : a journal of neurology
Key finding: Clinical findings in Parkinson's disease suggest that most patients progressively develop disabling non-levodopa-responsive symptoms during the course of the disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-10
Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
40/100 ✓ Peer-reviewed Inflammation and the immune system Expert reviews in molecular medicine
Key finding: For example, endothelial dysfunction has been implicated as a crucial event in the development of several CNS disorders, such as Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, multiple sclerosis, human immunodeficiency virus (HIV)-1-associated neurocognitive disorder and traumatic brain injury. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-10
Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Emerging evidences suggest that soluble Aβ oligomers adversely affect synaptic function, leading to cognitive failure associated with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-09
MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI
40/100 ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society
Key finding: The primary conclusions of the Task Force are that: (1) Parkinson's disease-mild cognitive impairment is common, (2) there is significant heterogeneity within Parkinson's disease-mild cognitive impairment in the number and types of cognitive domain impairments, (3) Parkinson's disease-mild cognitive impairment appears to place patients at risk of progressing to dementia, and (4) formal diagnostic criteria for Parkinson's disease-mild cognitive impairment are needed.
Full summary, score breakdown and related studies → Original source
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2011-06-07
Advance directives for euthanasia in dementia: how do they affect resident care in Dutch nursing homes? Experiences of physicians and relatives
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Advance directives for euthanasia are never adhered to in the Netherlands in the case of people with advanced dementia, and their role in advance care planning and end-of-life care of people with advanced dementia is limited.
Full summary, score breakdown and related studies → Original source
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2011-06-07
Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials
69/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: ChEIs may increase the risk of syncope, with no effects on falls, fracture, or accidental injury in cognitively impaired older adults. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-06-06
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
40/100 ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration
Key finding: This study identifies tau oligomers as an acutely toxic tau species in vivo, and suggests that tau oligomers induce neurodegeneration by affecting mitochondrial and synaptic function, both of which are early hallmarks in AD and other tauopathies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-04
A harmonized classification system for FTLD-TDP pathology
59/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica
Full summary, score breakdown and related studies → Original source
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2011-06-01
Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients
48/100 ✓ Peer-reviewed Clinical safety Archives of internal medicine
Key finding: STOPP criteria PIMs, unlike Beers criteria PIMs, are significantly associated with avoidable ADEs in older people that cause or contribute to urgent hospitalization. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-01
Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
36/100 ✓ Peer-reviewed Disparities Genetics in medicine : official journal of the American College of Medical Genetics
Key finding: Furthermore, research has demonstrated that testing individuals for apolipoprotein E can be valuable and safe in certain contexts.
Full summary, score breakdown and related studies → Original source
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2011-06-01
Caregiver care
36/100 ✓ Peer-reviewed End-of-life care American family physician
Key finding: Caring for loved ones is associated with several benefits, including personal fulfillment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-06-01
Cognitive reserve in aging
36/100 ✓ Peer-reviewed Risk factors Current Alzheimer research
Key finding: Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-01
Reliability of repeated cognitive assessment of dementia using a brief computerized battery
43/100 ✓ Peer-reviewed Cognitive tests and assessment American journal of Alzheimer's disease and other dementias
Key finding: In established dementia, administration of the CogState tasks appears sensitive to cognitive impairment in dementia.
Full summary, score breakdown and related studies → Original source
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2011-06-01
Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study
57/100 ✓ Peer-reviewed Cognitive tests and assessment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Progression of Alzheimer dementia (AD) is highly variable. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-01
Outcomes of mild cognitive impairment by definition: a population study
57/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology
Key finding: As ascertained by several operational definitions, MCI is a heterogeneous entity at the population level but progresses to dementia at rates higher than in normal elderly individuals.
Full summary, score breakdown and related studies → Original source
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2011-06-01
Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome
49/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology
Key finding: Consistent with neuropathological findings from postmortem studies, [(18)F]FDDNP positron emission tomography shows high binding levels in Down syndrome comparable to Alzheimer disease and greater levels than in members of a control group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-01
Wrist actigraphy
47/100 ✓ Peer-reviewed Risk factors Chest
Key finding: Clinical guidelines and research suggest that wrist actigraphy is particularly useful in the documentation of sleep patterns prior to a multiple sleep latency test, in the evaluation of circadian rhythm sleep disorders, to evaluate treatment outcomes, and as an adjunct to home monitoring of sleep-disordered breathing.
Full summary, score breakdown and related studies → Original source
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2011-06-01
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium
75/100 ✓ Peer-reviewed Caregiving Annals of neurology
Key finding: This large GWAS of WMH burden in community-based cohorts of individuals of European descent identifies a novel locus on chromosome 17. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-06-01
Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
68/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Our results suggest that diet may be a powerful environmental factor that modulates Alzheimer disease risk through its effects on central nervous system concentrations of Aβ42, lipoproteins, oxidative stress, and insulin. +1 more finding
Full summary, score breakdown and related studies → Original source
May 2011 1
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2011-05-31
New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia
36/100 ✓ Peer-reviewed Clinical safety Journal of clinical pharmacology
Key finding: The authors found significant dose-response relationships for the use of antipsychotics (hazard ratio [HR], 2.78; 95% confidence interval [CI], 1.49-5.17), anxiolytics (1.60; 1.20-2.14), hypnotics and sedatives (2.58; 1.42-4.68), and antidepressants (2.84; 1.93-4.16). +2 more findings
Full summary, score breakdown and related studies → Original source
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