Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,076–25,100 of 27,380 studies, newest first · page 1004 of 1096.
October 2001 3
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2001-10-01
A comprehensive, stage-sensitive model of grief in dementia caregiving
42/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Significant differences emerged between spouse and adult-child caregiver groups as a whole and as a function of Clinical Dementia Rating impairment level. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-10-01
Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis
53/100 ✓ Peer-reviewed Caregiving Research in nursing & health
Key finding: Because of conflicting results, in order to clarify the state of the science it was necessary to do a systematic analysis of the literature on research testing the effect of interventions on the burden of persons caring for family members with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-10-01
The Alzheimer's Disease Assessment Scale: evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer's disease
41/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: In 6-month trials, measurement error makes a substantial contribution to the variance in ADAS-Cog change scores.
Full summary, score breakdown and related studies → Original source
September 2001 22
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2001-09-25
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
53/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: Alzheimer's disease and Parkinson's disease are associated with the cerebral accumulation of beta-amyloid and alpha-synuclein, respectively.
Full summary, score breakdown and related studies → Original source
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2001-09-17
Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17
43/100 ✓ Peer-reviewed Drug development The Journal of biological chemistry
Key finding: Mutations in the human tau gene cause frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP-17). +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Amyloidosis: a convoluted story
43/100 ✓ Peer-reviewed Drug development British Journal of Haematology
Key finding: However, the fibrils in primary amyloidosis (AL) consist of the variable portion of a monoclonal light chain (κ or λ); secondary amyloidosis (AA) fibrils consist of protein A, a non-immunoglobulin; familial amyloidosis fibrils are usually composed of mutated transthyretin (prealbumin); senile systemic amyloid fibrils consist of normal transthyretin; and amyloid associated with long-term dialysis consists of β2-microglobulin. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Normalization of cerebral volumes by use of intracranial volume: implications for longitudinal quantitative MR imaging
50/100 ✓ Peer-reviewed Brain scans and imaging PubMed Central
Key finding: The TIV normalization of cross-sectional brain volumes significantly reduced interindividual variation; the coefficient of variation (CV) was reduced from 10.0% to 6.0% in controls (P <.001). +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-09 month only
Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease
77/100 ✓ Peer-reviewed Clinical trials International journal of geriatric psychiatry
Key finding: Patients treated with galantamine 24 mg/day had a significantly better outcome than placebo on ADAS-cog; the treatment difference was 3 points on the intention-to-treat (ITT) analysis ( p = 0.01) and 4.2 points on per protocol analysis ( p = 0.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09 month only
Donepezil in the treatment of patients with Alzheimer's disease
38/100 ✓ Peer-reviewed Treatments Expert review of neurotherapeutics
Key finding: Clinical placebo-controlled trials and open-label extension studies have consistently shown that donepezil is well tolerated and gives rise to statistically significant improvements in cognition, global function and activities of daily living for at least 12 months and to less deterioration of function possibly for more than 4 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-09-01
Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
36/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of neurology
Key finding: There is little or no neuronal loss in aging or preclinical AD but substantial loss in very mild AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-09-01
Neuropsychiatric aspects of Huntington's disease
36/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry
Key finding: Neuropsychiatric symptoms are prevalent in Huntington's disease and are relatively independent of cognitive and motor aspects of the disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-09-01
Glutamate uptake
36/100 ✓ Peer-reviewed Inflammation and the immune system Progress in neurobiology
Key finding: The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance of low and non-toxic concentrations of glutamate is now well documented.
Full summary, score breakdown and related studies → Original source
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2001-09-01
Health care management of adults with Down syndrome
36/100 ✓ Peer-reviewed Risk factors American family physician
Key finding: Patients with Down syndrome are likely to have a variety of illnesses, including thyroid disease, diabetes, depression, obsessive-compulsive disorder, hearing loss, atlantoaxial subluxation and Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Cholesterol and Alzheimer's disease: is there a link?
40/100 ✓ Peer-reviewed Drug development Neurology
Key finding: Two recent epidemiologic studies indicate that there is a decreased prevalence of AD associated with the use of cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase inhibitors or statins).
Full summary, score breakdown and related studies → Original source
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2001-09-01
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
40/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience
Key finding: Fibrillization studies demonstrated no difference in fibrillization rate, but Abeta with the Arctic mutation formed protofibrils at a much higher rate and in larger quantities than wild-type (wt) Abeta.
Full summary, score breakdown and related studies → Original source
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2001-09-01
MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging
Key finding: The two patient groups differed significantly from controls in entorhinal volume, but not from each other; in contrast, they differed from each other, as well as from controls, in hippocampal volume, with the mild AD cases showing the greatest atrophy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease
47/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of Aging
Full summary, score breakdown and related studies → Original source
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2001-09-01
Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease
46/100 ✓ Peer-reviewed Brain tissue and pathology Archives of neurology
Key finding: The prefrontal cortex (PFC) is a heterogeneous cortical structure that supports higher cognitive functions, including working memory and verbal abilities. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Homocysteine and cognitive decline in healthy elderly
39/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders
Key finding: Elevated levels might signal accelerated cognitive decline, although this remains to be established. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Applicability of the CERAD neuropsychological battery to Brazilian elderly
35/100 ✓ Peer-reviewed Cognitive tests and assessment Arquivos de neuro-psiquiatria
Key finding: A Portuguese version of CERAD neuropsychological battery was applied to a control group of healthy elderly (CG) (mean age 75.1 years/ education 7.9 years), 31 Alzheimer disease (AD) patients classified by clinical dementia rating (CDR) as CDR1 (71.4/ 9.0) and 12 AD patients CDR 2 (74.1/ 9.3). +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Delirium in older medical inpatients and subsequent cognitive and functional status: a prospective study
39/100 ✓ Peer-reviewed Cognitive tests and assessment CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Key finding: Delirium in older hospital inpatients appears to be associated with various adverse outcomes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Reduced levels of amyloid beta-peptide antibody in Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: Immunization with preaggregated amyloid beta-peptide (Abeta(1-42)) and administration of antibodies against Abeta into amyloid precursor protein APP(V717F)- transgenic mice (an animal model of AD) have recently been reported to dramatically reduce amyloid plaque deposition, neuritic dystrophy, and astrogliosis, most likely by enhancing Abeta clearance from brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation
56/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology
Key finding: Eleven DLB patients (7 Lewy body variant of AD [LBVAD] and 4 pure diffuse Lewy body disease [DLBD]) who had antemortem position emission tomography imaging and autopsy confirmation were compared to 10 autopsy-confirmed pure AD patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Lewy bodies and parkinsonism in families with parkin mutations
55/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology
Key finding: Classically, this disease has been associated with loss of dopaminergic neurons in the substantia nigra pars compacta and locus ceruleus, without Lewy body pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-09-01
Spontaneous speech of patients with dementia of the Alzheimer type and mild cognitive impairment
39/100 ✓ Peer-reviewed Digital health tools International psychogeriatrics
Key finding: This article discusses the potential of three assessments of language function in the diagnosis of Alzheimer-type dementia (DAT). +3 more findings
Full summary, score breakdown and related studies → Original source
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