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Retinal nerve fiber layer thickness in patients with Alzheimer disease
Kirbas S, Turkyilmaz K, Anlar O, Tufekci A, Durmus M.. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2013-03-01
Topic: Plasma and spinal-fluid biomarkers
The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) without visual impairment using spectral domain optical coherence tomography (SD-OCT) and to compare the results with healthy controls. A total of 80 subjects, including 40 patients with early untreated AD (mean age, 69.3 ± 4.9 years) and 40 healthy controls (mean age, 68.9 ± 5.1 years) were enrolled. Both eyes of patients with AD and controls were imaged using SD-OCT. The average RNFL thickness was significantly less in the AD patients than in controls (65 ± 6.2 μm vs 75 ± 3.8μm; P = 0.001). There was selective thinning of the RNFL in the superior quadrant, the mean superior quadrant RNFL thickness being 76 ± 6.7 μm in AD patients and 105 ± 4.8 μm in controls (P = 0.001). In our study, the thickness of RNFL in patient with AD was lower than that of controls. This suggests that SD- OCT has the potential to be used in the early diagnosis of AD as well as in the study of therapeutic agents. Further studies are needed to validate this technology as a viable ocular biomarker over time in AD.
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APA 7th
Kirbas, S., Turkyilmaz, K., Anlar, O., Tufekci, A., & Durmus, M. (2013). Retinal nerve fiber layer thickness in patients with Alzheimer disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. https://doi.org/10.1097/wno.0b013e318267fd5f
Vancouver
Kirbas S, Turkyilmaz K, Anlar O, Tufekci A, Durmus M. Retinal nerve fiber layer thickness in patients with Alzheimer disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2013. doi:10.1097/wno.0b013e318267fd5f. PMID: 22918296.
BibTeX
@article{kirbas2013-22918296,
author = {Kirbas, S. and Turkyilmaz, K. and Anlar, O. and Tufekci, A. and Durmus, M.},
title = {{Retinal nerve fiber layer thickness in patients with Alzheimer disease}},
journal = {Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society},
year = {2013},
doi = {10.1097/wno.0b013e318267fd5f},
pmid = {22918296},
url = {https://doi.org/10.1097/wno.0b013e318267fd5f}
}
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Key findings
- The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) without visual impairment using spectral domain optical coherence tomography (SD-OCT) and to compare the results with healthy controls.
- The average RNFL thickness was significantly less in the AD patients than in controls (65 ± 6.2 μm vs 75 ± 3.8μm; P = 0.001).
- This suggests that SD- OCT has the potential to be used in the early diagnosis of AD as well as in the study of therapeutic agents.
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Study details
- Participants80
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 80 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 22918296) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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