Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,201–18,225 of 27,380 studies, newest first · page 729 of 1096.
January 2014 5
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2014-01-01
Motor effects of radio electric asymmetric conveyer in Alzheimer's disease: results from a cross-over trial
57/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Axial movements improved at T3 and T4 after NPO and at T2 after sham NPO, but no significant effects were observed in axial movements in the second phase of the trial.
Full summary, score breakdown and related studies → Original source
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2014-01-01
A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease
71/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer's disease (AD) pathology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-01
Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial
79/100 ✓ Peer-reviewed Treatments JAMA
Key finding: Among patients with mild to moderate AD, 2000 IU/d of alpha tocopherol compared with placebo resulted in slower functional decline. +4 more findings
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2014-01-01
Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study
55/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Infant ε4 carriers had lower MWF and GMV measurements than noncarriers in precuneus, posterior/middle cingulate, lateral temporal, and medial occipitotemporal regions, areas preferentially affected by AD, and greater MWF and GMV measurements in extensive frontal regions and measurements were also significant in the subset of 2- to 6-month-old infants (MWF differences, P Conclusions and relevance While our findings should be considered preliminary, this study demonstrates some of the earliest brain changes associated with the genetic predisposition to AD.
Full summary, score breakdown and related studies → Original source
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2014-01-01
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
85/100 ✓ Peer-reviewed Treatments The New England journal of medicine
Key finding: Bapineuzumab did not improve clinical outcomes in patients with Alzheimer's disease, despite treatment differences in biomarkers observed in APOE ε4 carriers.
Full summary, score breakdown and related studies → Original source
December 2013 20
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2013-12-31
Experience and opinions on post-graduate dementia training in the UK: a survey of selected consultant geriatricians
32/100 ✓ Peer-reviewed Risk factors Age and Ageing
Key finding: Ninety-one per cent were consultant physicians, and 71% were not involved in outpatient diagnostic services. +4 more findings
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2013-12-28
Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits
36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: We demonstrated that pinocembrin exhibits neuroprotection through inhibition of the Aβ and/or RAGE pathway, but the therapeutic role and mechanism involved are not ascertained. +1 more finding
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2013-12-28
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment
42/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: We previously showed the framework of the γ-secretase cleavage, i.e. the stepwise successive processing of βCTF at every three (or four) amino acids. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-27
Barriers to the provision of high-quality palliative care for people with dementia in England: a qualitative study of professionals' experiences
40/100 ✓ Peer-reviewed End-of-life care Health & social care in the community
Key finding: Recordings were transcribed verbatim and analysed using thematic analysis with an inductive approach and a coding strategy. +4 more findings
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2013-12-25
Widening rural-urban disparities in all-cause mortality and mortality from major causes of death in the USA, 1969-2009
43/100 ✓ Peer-reviewed Risk factors Journal of urban health : bulletin of the New York Academy of Medicine
Key finding: Mortality rates increased with increasing levels of rurality overall and for non-Hispanic whites, blacks, and American Indians/Alaska Natives.
Full summary, score breakdown and related studies → Original source
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2013-12-24
Sleep and Alzheimer disease pathology--a bidirectional relationship
52/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: In experimental models, sleep deprivation increases the concentration of soluble Aβ and results in chronic accumulation of Aβ, whereas sleep extension has the opposite effect.
Full summary, score breakdown and related studies → Original source
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2013-12-24
The neuropathology of sport
51/100 ✓ Peer-reviewed Prevention and risk Acta neuropathologica
Key finding: Nonetheless, the play of sports is associated with risks, including a risk for mild TBI (mTBI) and, rarely, catastrophic traumatic injury and death. +3 more findings
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2013-12-23
Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration
36/100 ✓ Peer-reviewed Biomarkers The Journal of biological chemistry
Key finding: The observed changes associated with reactive glia highlighted some specific proteins that dominate the proteome in late-stage disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-22
Vision impairment and nutritional status among older assisted living residents
61/100 ✓ Peer-reviewed Risk factors Archives of gerontology and geriatrics
Key finding: It is a risk factor for disability, and it may be associated with nutritional status via decline in functional status. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-22
Latent feature representation with stacked auto-encoder for AD/MCI diagnosis
36/100 ✓ Peer-reviewed Digital health tools Brain structure & function
Key finding: We believe that there exist latent non-linear complicated patterns inherent in the low-level features such as relations among features. +4 more findings
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2013-12-21
Curcumin and Curcumin-like Molecules: From Spice to Drugs
36/100 ✓ Peer-reviewed Disease mechanisms Current Medicinal Chemistry
Key finding: A number of studies have shown that curcumin can be a prevention and a chemotherapeutic agent for colon, skin, oral and intestinal cancers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-21
Missense variant in TREML2 protects against Alzheimer's disease
69/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: Recent studies have identified a rare coding variant (p.R47H) in TREM2 that confers a high risk for Alzheimer's disease (AD). +3 more findings
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2013-12-20
Managing medications: the role of informal caregivers of older adults and people living with dementia. A review of the literature
36/100 ✓ Peer-reviewed Clinical safety Journal of clinical nursing
Key finding: Responsibility for managing medications for older adults and/or people living with dementia in the community often falls to informal caregivers. +1 more finding
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2013-12-20
Preserving Identity and Planning for Advance Care (PIPAC): preliminary outcomes from a patient-centered intervention for individuals with mild dementia
61/100 ✓ Peer-reviewed Disparities Aging & mental health
Key finding: Emotion-focused, patient-centered interventions like PIPAC hold promise for advancing treatment options in the early and mild stages of dementia.
Full summary, score breakdown and related studies → Original source
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2013-12-19
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
36/100 ✓ Peer-reviewed Inflammation and the immune system Cell stem cell
Key finding: Cortical slice recordings revealed both spontaneous and evoked synaptic responses in NeuroD1-converted neurons, suggesting that they integrated into local neural circuits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-19
Tau-aggregation inhibitor therapy for Alzheimer's disease
44/100 ✓ Peer-reviewed Brain tissue and pathology Biochemical pharmacology
Key finding: The Alzheimer neurofibrillary tangle is composed of tau and the core of its constituent filaments are made of a truncated fragment from the repeat domain of tau. +3 more findings
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2013-12-19
Characteristics of patients misdiagnosed with Alzheimer's disease and their medication use: an analysis of the NACC-UDS database
57/100 ✓ Peer-reviewed Long-term cohort studies BMC geriatrics
Key finding: This study compared individuals whose clinical diagnosis of Alzheimer's disease (AD) matched or did not match neuropathologic results at autopsy on clinical and functional outcomes (cognitive impairment, functional status and neuropsychiatric symptoms). +3 more findings
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2013-12-19
Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study
68/100 ✓ Peer-reviewed Prevention and risk BMJ (Clinical research ed.)
Key finding: Over follow-up, 449 (18.3%) participants developed dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-12-18
President's Perspective
9/100 ⚠ Report — not peer-reviewed Health systems and care delivery Neurology Report
Key finding: Some individuals who are DE receive full Medicaid coverage, whereas others only receive partial coverage, which does not cover hearing, vision, dental, or long-term care.1 Individuals who are DE tend to be medically complicated, often with 4 or more diagnoses, and many with chronic neurologic disorders (eg, poststroke, spinal cord injury, and multiple sclerosis) with or without mental (eg, retardation and dementia) or psychological disorders; in fact, recent estimates suggest that 40% to 50% of DE enrollees are disabled. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-12-18
MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The short Aβ peptide is derived from the large transmembrane Aβ precursor protein (APP). +3 more findings
Full summary, score breakdown and related studies → Original source
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