Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,601–18,625 of 27,380 studies, newest first · page 745 of 1096.
June 2013 25
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2013-06-27
Clinical phenotype of dementia after traumatic brain injury
46/100 ✓ Peer-reviewed Long-term cohort studies Journal of neurotrauma
Key finding: It is unclear whether TBI results in acceleration of Alzheimer's disease (AD)-like pathology or has features of another dementing condition, such as chronic traumatic encephalopathy, which is associated with more-prominent mood, behavior, and motor disturbances than AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-27
BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease
57/100 ✓ Peer-reviewed Risk factors PloS one
Key finding: The ability of the BrainAGE framework to correctly identify MCI-converters was compared with the performance of commonly used cognitive scales, hippocampus volume, and state-of-the-art biomarkers derived from cerebrospinal fluid (CSF). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-27
Referral to palliative care in COPD and other chronic diseases: a population-based study
44/100 ✓ Peer-reviewed Disparities Respiratory medicine
Key finding: Awareness of palliative care as an option for patients with COPD needs to increase in palliative care services, physicians and the general public.
Full summary, score breakdown and related studies → Original source
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2013-06-26
Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of cell science
Key finding: According to current concepts, the complex route whereby APP moves between the secretory compartment, the cell surface and endosomes to encounter the various secretases determines its processing fate. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-25
Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach
36/100 ✓ Peer-reviewed Biomarkers Journal of molecular biology
Key finding: J-coupling data calculated from the REMD trajectories were compared to corresponding NMR-derived values acquired through two different pulse sequences, revealing that all simulations converge on the order of hundreds of nanoseconds-per-replica toward ensembles that yield good agreement with experiment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-25
Structural development of the hippocampus and episodic memory: developmental differences along the anterior/posterior axis
59/100 ✓ Peer-reviewed Hippocampus size on brain scans Cerebral cortex (New York, N.Y. : 1991)
Key finding: We found that adults had a smaller right hippocampal head, larger hippocampal body bilaterally, and smaller right hippocampal tail compared with children. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-25
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics
40/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience
Key finding: The Wnt signaling pathway participates in the development of the central nervous system and growing evidence indicates that Wnts also regulate the function of the adult nervous system. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-24
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease
44/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry
Key finding: The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-22
Definition and description of schizophrenia in the DSM-5
58/100 ✓ Peer-reviewed Getting a diagnosis Schizophrenia research
Key finding: The clinical manifestations are extremely diverse, however, with this heterogeneity being poorly explained by the DSM-IV clinical subtypes and course specifiers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-21
Discrete Neural Correlates for the Recognition of Negative Emotions: Insights from Frontotemporal Dementia
40/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: The multimodal system model of emotion proposes that basic emotions are dependent on distinct brain regions, which undergo significant pathological changes in frontotemporal dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-21
Advance care planning and physician orders in nursing home residents with dementia: a nationwide retrospective study among professional caregivers and relatives
40/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Communication regarding care is rarely patient driven and more often professional caregiver or family driven.
Full summary, score breakdown and related studies → Original source
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2013-06-21
Fluid biomarkers in Alzheimer's disease - current concepts
56/100 ✓ Peer-reviewed Mild cognitive impairment Molecular neurodegeneration
Key finding: We also review results from blood biomarker studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-21
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
62/100 ✓ Peer-reviewed Risk factors Molecular neurodegeneration
Key finding: Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-21
Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice
46/100 ✓ Peer-reviewed Prevention and risk Psychoneuroendocrinology
Key finding: In addition, in HFD-induced hyperinsulinemia in C57Bl6 mice, we only observed mild CNS alterations, suggesting that central nervous system dysfunction is associated with well established T2D. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-20
Proinflammatory cytokines, aging, and age-related diseases
52/100 ✓ Peer-reviewed Inflammation and the immune system Journal of the American Medical Directors Association
Key finding: Aging is associated with increased levels of circulating cytokines and proinflammatory markers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-20
Potentially preventable complications of urinary tract infections, pressure areas, pneumonia, and delirium in hospitalised dementia patients: retrospective cohort study
55/100 ✓ Peer-reviewed Clinical safety BMJ open
Key finding: Compared with non-dementia patients, hospitalised dementia patients have higher rates of potentially preventable complications that might be responsive to nursing interventions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-20
One-year repeated cycles of cognitive training (CT) for Alzheimer's disease
72/100 ✓ Peer-reviewed Prevention trials Aging clinical and experimental research
Key finding: Present results suggest that repeated cycles of CT in patients with AD treated with ChEIs are associated with benefits in several areas of cognitive function. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-20
Nutrition and the risk of Alzheimer's disease
47/100 ✓ Peer-reviewed Prevention trials BioMed research international
Key finding: Increasing epidemiological studies suggest that diet and nutrition might be important modifiable risk factors for AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-20
Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807
48/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer s Disease
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2013-06-19
Screening for cognition and behaviour changes in ALS
44/100 ✓ Peer-reviewed Caregiving Amyotrophic lateral sclerosis & frontotemporal degeneration
Key finding: In conclusion, the ECAS is an effective within-clinic assessment for ALS that determines the presence, severity and type of cognitive and/or behavioural changes, an essential first step to managing these symptoms.
Full summary, score breakdown and related studies → Original source
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2013-06-18
Understanding the needs of family caregivers of older adults dying with dementia
36/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: Supporting family caregivers of individuals with dementia throughout the disease trajectory requires consideration of caregivers : (1) physical, emotional, and psychological needs; (2) information and decisional support needs; and (3) instrumental support needs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-06-18
The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort
59/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry
Key finding: (1) outlook in PD is heterogeneous, with most dying or developing dementia or postural instability by 10 years from diagnosis, but a quarter still doing well, with preserved mobility and intact cognition; (2) death is not directly related to PD in the majority; (3) baseline clinical and genetic variables are predictive of outcome and may be helpful in selecting patients for clinical trials.
Full summary, score breakdown and related studies → Original source
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2013-06-17
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
36/100 ✓ Peer-reviewed Risk factors Proceedings of the National Academy of Sciences of the United States of America
Key finding: In AD-transgenic mice compared with wild type, whole-cell recordings revealed excessive tonic eNMDAR activity accompanied by eNMDAR-sensitive loss of mEPSCs.
Full summary, score breakdown and related studies → Original source
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2013-06-17
Quality of end-of-life care of long-term nursing home residents with and without dementia
67/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: NHs appear to provide less-aggressive end-of-life care to decedents with dementia than to those without. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-06-17
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
63/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Partial volume corrected and uncorrected results were generally in agreement; however, the correlation between (11)C-PBR28 and (11)C-Pittsburgh Compound B binding was seen only after partial volume correction. +1 more finding
Full summary, score breakdown and related studies → Original source
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