Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,476–18,500 of 27,380 studies, newest first · page 740 of 1096.
August 2013 25
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2013-08-13
Inflammatory process in Alzheimer's Disease
45/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in integrative neuroscience
Key finding: Histopathologically is characterized by the presence of two major hallmarks, the intracellular neurofibrillary tangles (NFTs) and extracellular neuritic plaques (NPs) surrounded by activated astrocytes and microglia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-08-12
Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
50/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: SUVr(60-90) and SUVr(40-60) overestimated binding with 13% and 10%, respectively, compared with RPM2.
Full summary, score breakdown and related studies → Original source
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2013-08-12
Brain atrophy in type 2 diabetes: regional distribution and influence on cognition
66/100 ✓ Peer-reviewed Brain scans and imaging Diabetes care
Key finding: Neurodegeneration rather than cerebrovascular lesions may play a key role in T2DM-related cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-11
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits
43/100 ✓ Peer-reviewed Disease mechanisms Nature neuroscience
Key finding: Our findings implicate aberrant eIF2α phosphorylation as a previously unidentified molecular mechanism underlying Alzheimer's disease-related synaptic pathophysioloy and memory dysfunction and suggest that PERK and GCN2 are potential therapeutic targets for treatment of individuals with Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2013-08-09
Neuropathologic basis of white matter hyperintensity accumulation with advanced age
58/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Accumulating white matter changes in advanced age are likely driven by small-vessel ischemic disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-08-09
Relations of arterial stiffness and endothelial function to brain aging in the community
55/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Greater arterial stiffness and pressure pulsatility are associated with brain aging, MRI vascular insults, and memory deficits typically seen in Alzheimer dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-08
The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology
47/100 ✓ Peer-reviewed Risk genes beyond APOE PloS one
Key finding: These effects have been related to the protection against cognitive decline associated with aging and disease by a number of polyphenols found in red wine and extra virgin olive oil. +3 more findings
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2013-08-07
Introducing dyadic interviews as a method for collecting qualitative data
36/100 ✓ Peer-reviewed Caregiving Qualitative health research
Key finding: We conclude with a discussion of directions for future research using dyadic interviews.
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2013-08-07
The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
64/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This article reviews all papers published since the inception of the initiative and summarizes the results as of February 2011.
Full summary, score breakdown and related studies → Original source
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2013-08-07
Improving the end-of-life for people with dementia living in a care home: an intervention study
43/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: This small non-randomized study is the first end-of-life care in dementia intervention to report an increase in family satisfaction with a reduction in hospital deaths. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-07
End-of-life communication: a retrospective survey of representative general practitioner networks in four countries
43/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: The prevalence of end-of-life discussions varied across the four countries. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-07
Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer's or vascular type: a review
67/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy
Key finding: Overall estimates of the treatment effect were calculated by using a fixed-effects model, and statistical heterogeneity was measured by using a standard chi-squared statistic. +4 more findings
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2013-08-06
The role of autophagy in neurodegenerative disease
41/100 ✓ Peer-reviewed Disease mechanisms Nature medicine
Key finding: Neurons are particularly vulnerable to disruptions of these interactions, especially as the brain ages. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-08-06
Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity
62/100 ✓ Peer-reviewed Prevention trials NeuroImage
Key finding: We used cognitive training to test the hypothesis that far transfer is associated with altered attentional control demands mediated by the dorsal attention network and trained sensory cortex. +4 more findings
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2013-08-06
Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study
48/100 ✓ Peer-reviewed Long-term cohort studies Stroke
Key finding: Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. +3 more findings
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2013-08-02
Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study
78/100 ✓ Peer-reviewed Drug development Neurology
Key finding: Diuretic, ARB, and ACE-I use was, in addition to and/or independently of mean systolic blood pressure, associated with reduced risk of AD dementia in participants with normal cognition, while only diuretic use was associated with reduced risk in participants with MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-08-01
The state of US health, 1990-2010: burden of diseases, injuries, and risk factors
69/100 ✓ Peer-reviewed Risk factors JAMA
Key finding: Healthy life expectancy (HALE) was used to summarize overall population health, accounting for both length of life and levels of ill health experienced at different ages. +1 more finding
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2013-08-01
Development of a new method for assessing global risk of Alzheimer's disease for use in population health approaches to prevention
55/100 ✓ Peer-reviewed Prevention trials Prevention science : the official journal of the Society for Prevention Research
Key finding: Increasing evidence suggests that many risk factors for AD are modifiable. +1 more finding
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2013-08-01
The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease
40/100 ✓ Peer-reviewed Drug development Neuropathology and applied neurobiology
Key finding: The present data show that CAA plays a role in the development of microvascular lesions in the ageing brain, but cannot be considered as the most important factor in this vascular pathology, suggesting that other mechanisms also contribute importantly to the pathogenesis of microvascular changes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-08-01
CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing
36/100 ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: In summary, these results suggest a novel model wherein SNP-modulated RNA splicing modulates CD33 function and, thereby, AD risk.
Full summary, score breakdown and related studies → Original source
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2013-08-01
Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial
67/100 ✓ Peer-reviewed Cognitive tests and assessment The Journal of clinical psychiatry
Key finding: In a recent crossover trial, methylphenidate treatment decreased apathy in Alzheimer's disease. +3 more findings
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2013-08-01
Acetylated tau neuropathology in sporadic and hereditary tauopathies
45/100 ✓ Peer-reviewed Risk genes beyond APOE The American journal of pathology
Key finding: Herein, we extend our observations using IHC with a polyclonal antibody specific for AC-K280. +3 more findings
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2013-08-01
Mild cognitive impairment due to Alzheimer disease in the community
60/100 ✓ Peer-reviewed Mild cognitive impairment Annals of neurology
Key finding: The NIA-AA criteria apply to most MCI subjects in both the community and clinical trials settings; however, a sizeable proportion of subjects had conflicting biomarkers, which may be very important and need to be explored. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-01
Salience network-based classification and prediction of symptom severity in children with autism
60/100 ✓ Peer-reviewed Lewy body dementia JAMA psychiatry
Key finding: Salience network hyperconnectivity may be a distinguishing feature in children with ASD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-08-01
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis
58/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Breakthrough discoveries identifying common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these disorders. +3 more findings
Full summary, score breakdown and related studies → Original source
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