Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,851–24,875 of 27,380 studies, newest first · page 995 of 1096.
May 2002 23
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2002-05-01
Hippocampal neurons in schizophrenia
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Neuropsychiatric disorders such as temporal lobe epilepsy, amnesia, and the dementias are associated with structural and functional abnormalities of specific hippocampal neurons. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Decision making in terminal care: a survey of finnish doctors' treatment decisions in end-of-life scenarios involving a terminal cancer and a terminal dementia patient
36/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Main results In the cancer case (Scenario 1) 17%, and in the dementia case (Scenario 2) 43% of all the respondents chose active treatment.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Assessing differences in care needs and service utilization in geriatric palliative care patients
36/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: There were statistically significant differences across age groups in patient demographic and clinical characteristics, advance care planning, and service utilization.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Palliative and aggressive end-of-life care for patients with dementia
45/100 ✓ Peer-reviewed End-of-life care Psychiatric services (Washington, D.C.)
Key finding: Use of systemic antibiotics is prevalent in the treatment of patients with end-stage dementia, despite the limited utility and discomfort associated with the use of these agents. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Reduced mortality in treating acutely sick, frail older patients in a geriatric evaluation and management unit. A prospective randomized trial
72/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: Treatment of acutely sick, frail, older patients in a GEMU substantially reduced mortality. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-05-01
An open trial of olanzapine for the treatment of delirium in hospitalized cancer patients
41/100 ✓ Peer-reviewed Clinical safety Psychosomatics
Key finding: Several factors were found to be significantly associated with poorer response to olanzapine treatment for delirium, including age >70 years, history of dementia, central nervous system spread of cancer and hypoxia as delirium etiologies, "hypoactive" delirium, and delirium of "severe" intensity (i.e., MDAS >23). +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-05-01
Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study
55/100 ✓ Peer-reviewed Clinical safety Annals of neurology
Key finding: The presence of memory impairment was associated with more severe Alzheimer's disease pathology and higher incidence of conversion to dementia in the groups classified as having mild or global cognitive impairments. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Involvement of Maillard reactions in Alzheimer disease
36/100 ✓ Peer-reviewed Disease mechanisms Neurotoxicity research
Key finding: It is hoped that understanding of the mechanism of the AGEs formation and their role in the neurodegeneration will result in novel therapeutics for neuroprotection.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Coding Options for Central Auditory Processing
24/100 ✓ Peer-reviewed Health systems and care delivery ASHA Leader
Key finding: Scenario #1—Use of test battery code 92557 Comprehensive audiometry threshold $44.53 92567 Tympanometry $19.91 92568 Acoustic Reflex Testing $14.12 92569 Acoustic Reflex Decay Testing $15.20 92506 Evaluation of speech, language, voice, communication, and/or auditory processing $94.84 Total $188.60 CPT 92506, a code that represents a battery of tests, has a higher work value (i.e., higher reimbursement rate) associated with it than CPT codes for individual CAP tests (e.g., Staggered Spondaic Word test). +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-05-01
Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
51/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry
Key finding: A highly conserved pattern of carboxyterminally truncated Abeta1-37/38/39 was found in addition to Abeta1-40 and Abeta1-42. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Role of nitric oxide in inflammation-mediated neurodegeneration
49/100 ✓ Peer-reviewed Inflammation and the immune system Annals of the New York Academy of Sciences
Key finding: The hallmark of brain inflammation is the activation of glial cells, especially that of microglia that produce a variety of proinflammatory and neurotoxic factors, including cytokines, fatty acid metabolites, free radicals--such as nitric oxide (NO) and superoxide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH
46/100 ✓ Peer-reviewed Brain tissue and pathology Oncogene
Key finding: HIV-1 target cells in the brain include microglia, infiltrating macrophages and astrocytes, but rarely neurons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Post-stroke depression, executive dysfunction and functional outcome
51/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of neurology
Key finding: We sought to examine the correlates of executive dysfunction in a well-defined stroke cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Antioxidant strategies for Alzheimer's disease
40/100 ✓ Peer-reviewed Mild cognitive impairment The Proceedings of the Nutrition Society
Key finding: In AD clinical trials molecules with antioxidant properties such as vitamin E and Ginkgo biloba extract have shown modest benefit. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
48/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Furthermore, manipulation of other wingless signaling molecules downstream from shaggy demonstrated that components of the Wnt signaling pathway modulate neurodegeneration induced by tau pathology in vivo but suggested that tau phosphorylation by GSK-3beta differs from canonical Wnt effects on beta-catenin stability and TCF activity.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Where does parkinson disease pathology begin in the brain?
49/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology
Key finding: Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex, in projection neurons of the intermediate reticular zone, and in specific nerve cell types of the gain setting system (coeruleus-subcoeruleus complex, caudal raphe nuclei, gigantocellular reticular nucleus), olfactory bulb, olfactory tract, and/or anterior olfactory nucleus in the absence of nigral involvement.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF
31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging
Key finding: IMPase activity was relatively constant in CSF obtained from repeated lumbar puncture and there was no significant rostro-caudal gradient of activity in either normal or DS subjects, indicating that the enzyme originates from both brain and spinal cord. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Minority ethnic groups in dementia care: a review of service needs, service provision and models of good practice
40/100 ✓ Peer-reviewed Disparities Aging & mental health
Key finding: Although it has been argued that the instruments used to assess cognitive function are culturally biased, the available published evidence would seem to suggest that the fundamental issue is language ability, rather than minority group membership per se.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Measurement and correlates of family caregiver self-efficacy for managing dementia
46/100 ✓ Peer-reviewed Caregiving Aging & mental health
Key finding: Symptom management self-efficacy demonstrated a much stronger correlation with a published global caregiver competence measure than did service use self-efficacy (r = 0.49 and 0.27, respectively). +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-05-01
Assessing quality of life in older adults with cognitive impairment
53/100 ✓ Peer-reviewed Caregiving Psychosomatic medicine
Key finding: The QOL-AD seems to be reliable and valid for individuals with MMSE scores greater than 10.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Postmortem MRI scans were obtained for the first 56 participants of the Nun Study who were scanned.
Full summary, score breakdown and related studies → Original source
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2002-05-01
Falls in cognitive impairment and dementia
39/100 ✓ Peer-reviewed Prevention and risk Clinics in geriatric medicine
Key finding: Older people with cognitive impairment and dementia are at increased risk for falls and subsequent adverse events. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-05-01
Alzheimer disease and cerebrovascular pathology: an update
49/100 ✓ Peer-reviewed Genetics Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Vascular pathology in the aging brain and in AD includes: 1. cerebral amyloid angiopathy (CAA) with an incidence of 82-98% often associated with ApoE epsilon 2 and causing a) cerebral mass hemorrhages (around 70%, mainly in the frontal and parietal lobes), b) multiple or recurrent microhemorrhages (15%), and c) ischemic (micro-)infarcts or lacunes (around 20%). +2 more findings
Full summary, score breakdown and related studies → Original source
April 2002 2
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2002-04-15
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
59/100 ✓ Peer-reviewed Cognitive tests and assessment Principles and Practice of Geriatric Psychiatry
Key finding: Accordingly, this program developed and evaluated clinical, neuropsychological and neuropathological assessments, an approach to neuroimaging, a standardized means of obtaining family history, and a behavior rating scale, as well as other measures. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-04-01
Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness
38/100 ✓ Peer-reviewed Tau biomarkers Frontiers in bioscience : a journal and virtual library
Key finding: In the GTT2 study, assays of the CSF Abeta ratio ((Abeta40/ Abeta42(43)) showed a diagnostic sensitivity (59%) and specificity (88%) compared with non-AD type dementia and controls.
Full summary, score breakdown and related studies → Original source
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