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Structural development of the hippocampus and episodic memory: developmental differences along the anterior/posterior axis
DeMaster D, Pathman T, Lee JK, Lee JK, Ghetti S.. Cerebral cortex (New York, N.Y. : 1991), 2013-06-25
Topic: Brain proteins, microglia and lab models
The hippocampus is critically involved in episodic memory, yet relatively little is known about how the development of this structure contributes to the development of episodic memory during middle to late childhood. Previous research has inconsistently reported associations between hippocampal volume and episodic memory performance during this period. We argue that this inconsistency may be due to assessing the hippocampus as a whole, and propose to examine associations separately for subregions along the longitudinal axis of the hippocampus. In the present study, we examined age-related differences in volumes of the hippocampal head, body, and tail, and collected episodic memory measures in children ages 8-11 years and young adults (N = 62). We found that adults had a smaller right hippocampal head, larger hippocampal body bilaterally, and smaller right hippocampal tail compared with children. In adults, but not in children, better episodic memory performance was associated with smaller right hippocampal head and larger hippocampal body. In children, but not in adults, better episodic memory was associated with larger left hippocampal tail. Overall, the results suggest that protracted development of hippocampal subregions contribute to age-related differences in episodic memory.
Key findings
- We found that adults had a smaller right hippocampal head, larger hippocampal body bilaterally, and smaller right hippocampal tail compared with children.
- In adults, but not in children, better episodic memory performance was associated with smaller right hippocampal head and larger hippocampal body.
- In children, but not in adults, better episodic memory was associated with larger left hippocampal tail.
- Overall, the results suggest that protracted development of hippocampal subregions contribute to age-related differences in episodic memory.
Study details
- Study designlongitudinal study
- Participants62
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cerebral cortex (New York, N.Y. : 1991)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 62 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23800722) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
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APA 7th
DeMaster, D., Pathman, T., Lee, J. K., & Ghetti, S. (2014). Structural development of the hippocampus and episodic memory: developmental differences along the anterior/posterior axis. Cerebral cortex (New York, N.Y. : 1991). https://doi.org/10.1093/cercor/bht160
Vancouver
DeMaster D, Pathman T, Lee JK, Ghetti S. Structural development of the hippocampus and episodic memory: developmental differences along the anterior/posterior axis. Cerebral cortex (New York, N.Y. : 1991). 2014. doi:10.1093/cercor/bht160. PMID: 23800722.
BibTeX
@article{demaster2014-23800722,
author = {DeMaster, D. and Pathman, T. and Lee, J. K. and Ghetti, S.},
title = {{Structural development of the hippocampus and episodic memory: developmental differences along the anterior/posterior axis}},
journal = {Cerebral cortex (New York, N.Y. : 1991)},
year = {2014},
doi = {10.1093/cercor/bht160},
pmid = {23800722},
url = {https://doi.org/10.1093/cercor/bht160}
}