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Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease
Willnow TE, Andersen OM.. Journal of cell science, 2013-06-26
Topic: Brain proteins, microglia and lab models
Excessive proteolytic breakdown of the amyloid precursor protein (APP) to neurotoxic amyloid β peptides (Aβ) by secretases in the brain is a molecular cause of Alzheimer disease (AD). According to current concepts, the complex route whereby APP moves between the secretory compartment, the cell surface and endosomes to encounter the various secretases determines its processing fate. However, the molecular mechanisms that control the intracellular trafficking of APP in neurons and their contribution to AD remain poorly understood.
Key findings
- According to current concepts, the complex route whereby APP moves between the secretory compartment, the cell surface and endosomes to encounter the various secretases determines its processing fate.
- However, the molecular mechanisms that control the intracellular trafficking of APP in neurons and their contribution to AD remain poorly understood.
- Here, we describe the functional elucidation of a new sorting receptor SORLA that emerges as a central regulator of trafficking and processing of APP.
- SORLA interacts with distinct sets of cytosolic adaptors for anterograde and retrograde movement of APP between the trans-Golgi network and early endosomes, thereby restricting delivery of the precursor to endocytic compartments that favor amyloidogenic breakdown.
Why it matters
This work describes the sorting receptor SORLA as a central regulator of trafficking and processing of amyloid precursor protein. It explains a possible molecular route relevant to disease but reports no treatment or prevention tested in people.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of cell science) |
| Journal's citation record | 3 / 4 | Journal of Cell Science: journal h-index 385 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 122 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.1 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 9.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Olav M. Andersen: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Aarhus University: institution h-index 976 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23813966) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Willnow, T. E., & Andersen, O. M. (2013). Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. Journal of cell science. https://doi.org/10.1242/jcs.125393
Vancouver
Willnow TE, Andersen OM. Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. Journal of cell science. 2013. doi:10.1242/jcs.125393. PMID: 23813966.
BibTeX
@article{willnow2013-23813966,
author = {Willnow, T. E. and Andersen, O. M.},
title = {{Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease}},
journal = {Journal of cell science},
year = {2013},
doi = {10.1242/jcs.125393},
pmid = {23813966},
url = {https://doi.org/10.1242/jcs.125393}
}
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