alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 8,026–8,050 of 27,380 studies, newest first · page 322 of 1096.

January 2023 25

  1. 2023-01-18

    APOE differentially moderates cerebrospinal fluid and plasma phosphorylated tau181 associations with multi-domain cognition

    ✓ Peer-reviewed Genetics Neurobiology of aging

    Key finding: CSF and plasma p-tau181 were significantly associated with memory, and this effect was greater in APOE ε4 carriers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-01-17

    Integration of amyloid-β oligomerization tendency as a plasma biomarker in Alzheimer's disease diagnosis

    ✓ Peer-reviewed Biomarkers Frontiers in neurology

    Key finding: A systematic interpretation strategy could support accurate diagnosis and staging of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2023-01-17

    GSN gene frameshift mutations in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

    Key finding: Six patients with AD with GSN P3fs and K346fs mutations (0.50%, 6/1192) were identified, who were diagnosed with AD but not FAF. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-01-17

    Association of social isolation and loneliness with risk of incident hospital-treated infections: an analysis of data from the UK Biobank and Finnish Health and Social Support studies

    ✓ Peer-reviewed Long-term cohort studies The Lancet. Public health

    Key finding: Although loneliness and social isolation have been linked to an increased risk of non-communicable diseases such as cardiovascular disease and dementia, their association with the risk of severe infection is uncertain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2023-01-17

    TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD

    ✓ Peer-reviewed TREM2 and immune genetics Cells

    Key finding: In mice and humans, NAFLD progression is characterized by the appearance of TREM2-expressing macrophages in the liver. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-01-16

    Droplet-based transcriptome profiling of individual synapses

    ✓ Peer-reviewed Genetics Nature biotechnology

    Key finding: In the synaptosome transcriptome, or 'synaptome', profiling of both mouse and human brain samples, we detect subclusters among synaptosomes that are associated with neuronal subtypes and characterize the landscape of transcript splicing that occurs within synapses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2023-01-16

    Plasma biomarkers for neurodegenerative disorders: ready for prime time?

    ✓ Peer-reviewed Biomarkers Current opinion in psychiatry

    Key finding: Recent findings Plasma biomarkers have significantly improved our understanding of ADRD time-course, risk factors, diagnosis and prognosis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-01-16

    The Cumulative Use of Muscle Relaxants and the Risk of Alzheimer's Disease: A Nationwide Case-Control Study

    ✓ Peer-reviewed Health systems and care delivery Journal of Alzheimer's disease : JAD

    Key finding: To investigate if the use of muscle relaxants is associated with the risk of Alzheimer's disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-01-16

    Anorexia in Medicare Fee-for-Service Beneficiaries: A Claims-Based Analysis of Epidemiology and Mortality

    ✓ Peer-reviewed Health systems and care delivery The journal of nutrition health & aging

    Key finding: The number of individuals with anorexia ranged from 317,964 to 328,977 per year, a mean annual prevalence rate of 1.1%. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-01-15

    Conjunctival microcirculation in ocular and systemic microvascular disease

    ✓ Peer-reviewed Brain scans and imaging Clinical & experimental optometry

    Key finding: Currently, algorithms for the measurement of conjunctival haemodynamics use either manual or semi-automated systems, which may provide insight into overall conjunctival health, as well as in ocular and systemic disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2023-01-13

    ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed Disease mechanisms Science (New York, N.Y.)

    Key finding: Apolipoprotein E (ApoE)-mediated neuroinflammation is involved in the progression of tau-mediated neurodegeneration, and emerging evidence suggests that the gut microbiota regulates neuroinflammation in an APOE genotype-dependent manner.

    Full summary, score breakdown and related studies → Original source

  12. 2023-01-13

    Prevalence of dementia in India: National and state estimates from a nationwide study

    ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: An estimated 8.8 million Indians older than 60 years have dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2023-01-12

    Vitamin D and neurodegenerative diseases

    ✓ Peer-reviewed Prevention and risk Heliyon

    Key finding: Cumulative evidence indicates that vitamin D can ameliorate neurodegeneration by regulating pertinent molecules and signaling pathways including maintaining Ca2+ homeostasis, reducing oxidative stress, inhibiting inflammation, suppressing the formation and aggregation of the pathogenic protein, etc.

    Full summary, score breakdown and related studies → Original source

  14. 2023-01-12

    Predictors of falls in older adults with and without dementia

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Fall rates were higher among PLWD compared to persons without dementia (45.5% vs. 30.9%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-01-12

    TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis

    ✓ Peer-reviewed TREM2 and immune genetics Nature metabolism

    Key finding: Owing to cellular heterogeneity, understanding the roles of immune cell subsets in SICM has been challenging. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2023-01-12

    A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

    ✓ Peer-reviewed TREM2 and immune genetics Nature neuroscience

    Key finding: Here we describe a high-affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle (ATV), to facilitate blood-brain barrier transcytosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-01-10

    Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity

    ✓ Peer-reviewed Disease mechanisms Redox biology

    Key finding: Then, using the verified chemogenetic tool, we emulated isolated intraneuronal oxidative stress in acute brain slices and, using electrophysiological recordings, revealed that it does not alter basal synaptic transmission and the probability of neurotransmitter release from presynaptic terminals but reduces long-term potentiation (LTP). +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2023-01-10

    APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology

    ✓ Peer-reviewed Genetics Annals of neurology

    Key finding: We found that TDP-43 overexpression induced motor function deficits, neuronal loss, and gliosis in the motor cortex, especially in APOE2 mice, with much milder or absent effects in APOE3, APOE4, or Apoe-KO mice. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-01-09

    Optical coherence tomography and angiography in Alzheimer's disease and other cognitive disorders

    ✓ Peer-reviewed Brain scans and imaging European journal of ophthalmology

    Key finding: Ninety-one eyes of AD patients and 53 eyes of patients with other dementias were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2023-01-09

    Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies

    ✓ Peer-reviewed Prevention trials Nutrients

    Key finding: Overall, 59% of prospective studies reported positive associations between healthy DPs and risk of cognitive disorder. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2023-01-09

    sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine

    Key finding: Here, we used CSF sTREM2 to investigate disease stage-dependent drivers of microglial activation and to determine downstream consequences on AD progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2023-01-09

    Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer's Disease (EPAD) cohort

    ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy

    Key finding: HRT introduction is associated with improved delayed memory and larger entorhinal and amygdala volumes in APOE4 carriers only. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2023-01-08

    The worldwide costs of dementia in 2019

    ✓ Peer-reviewed Costs and economics Alzheimer s & Dementia

    The huge costs of dementia worldwide place enormous strains on care systems and families alike.

    Full summary, score breakdown and related studies → Original source

  24. 2023-01-06

    Drug Repurposing to Inhibit Histamine N-Methyl Transferase

    ✓ Peer-reviewed Drug development Molecules (Basel, Switzerland)

    Key finding: Lower activity of the histaminergic system is associated with neurological disorders, including Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2023-01-06

    Tau-aggregation inhibitors derived from Streptomyces tendae MCCC 1A01534 protect HT22 cells against okadaic acid-induced damage

    ✓ Peer-reviewed Drug development International journal of biological macromolecules

    Key finding: By ThT assay, transmission electron microscopy, and circular dichroism, we demonstrated that the angucyclinones 2 and 3 inhibited tau aggregation and disaggregated tau fibrils. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →