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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Risk genes beyond APOE

Topic: Brain proteins, microglia and lab models

Plain-language summary

Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that attenuates Aβ production and prevents cognitive decline in AD mice. Our follow‐up study assessed whether enhancing APP‐mediated signaling affected sleep. METHODS We expressed a membrane‐tethered APP intracellular domain (mAICD) and a variant lacking the Gα S ‐interacting site in AD mouse brains. Sleep patterns, cognitive behaviors, blood–brain barrier (BBB) integrity, and gliosis were examined. RESULTS Sleep, BBB integrity, and memory were strongly correlated. mAICD expression rescued sleep and cognitive function impairments, prevented BBB leakage, and promoted astrocyte redistribution surrounding the neurovascular units in AD mice. Gα S interaction with mAICD was critical. DISCUSSION APP‐mediated signaling plays a key role in regulating sleep, maintaining BBB integrity, and preserving memory in AD.

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APA 7th

Puech, C., Sadanand, A., Coleman, N. M., Ikhane, M., Badran, M., Wang, R., et al. (2026). APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model. Alzheimer s & Dementia. https://doi.org/10.1002/alz.71134

Vancouver

Puech C, Sadanand A, Coleman NM, Ikhane M, Badran M, Wang R, et al. APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model. Alzheimer s & Dementia. 2026. doi:10.1002/alz.71134. PMID: 41630648.

BibTeX

@article{puech2026-41630648,
  author  = {Puech, Clémentine and Sadanand, Anjana and Coleman, Neil M. and Ikhane, Marilyn and Badran, Mohammad and Wang, Rong and Gozal, David and Parent, A.},
  title   = {{APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71134},
  pmid    = {41630648},
  url     = {https://doi.org/10.1002/alz.71134}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

RESULTS Sleep, BBB integrity, and memory were strongly correlated. mAICD expression rescued sleep and cognitive function impairments, prevented BBB leakage, and promoted astrocyte redistribution surrounding the neurovascular units in AD mice.

Why it matters

In Alzheimer's disease mouse models, expressing a membrane-tethered APP intracellular domain rescued sleep and cognitive impairments, prevented blood-brain barrier leakage, and promoted astrocyte redistribution. This is an animal study showing that APP-mediated signaling plays a role in sleep, blood-brain barrier integrity and memory, but it does not establish a treatment for people.

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Study details

Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 36 of the 96 points we could judge it on, which is 38 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “mouse”) — scores zero
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.5 citations a year over 2 year(s) since 2026
Impact for its field and year	3 / 6	Cited 4.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author A. Parent holds only 3 work(s), too few to judge a track record — left out of this score
Institution's track record	1 / 3	University of South Florida: institution h-index 806 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41630648)
Free to read	2 / 2	Free to read
Points	36 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 36 of the 96 points we could judge it on is 38 out of 100.
Total	38 / 100	—

What each of these 20 components measures, and what this score is not →

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